Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.

Autor: Skovsø S; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Panzhinskiy E; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Kolic J; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Cen HH; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Dionne DA; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Dai XQ; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada., Sharma RB; Division of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA., Elghazi L; Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA., Ellis CE; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Faulkner K; Department of Mathematics, University of British Columbia, Vancouver, BC, Canada., Marcil SAM; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Overby P; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Noursadeghi N; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Hutchinson D; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Hu X; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Li H; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Modi H; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Wildi JS; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Botezelli JD; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Noh HL; Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.; Charles River Laboratories, Shrewsbury, MA, USA., Suk S; Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA., Gablaski B; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Charles River Laboratories, Shrewsbury, MA, USA., Bautista A; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada., Kim R; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada., Cras-Méneur C; Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA., Flibotte S; UBC Life Sciences Institute Bioinformatics Facility, University of British Columbia, Vancouver, BC, Canada., Sinha S; UBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada., Luciani DS; BC Children's Hospital Research Institute, Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Nislow C; UBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada., Rideout EJ; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada., Cytrynbaum EN; Department of Mathematics, University of British Columbia, Vancouver, BC, Canada., Kim JK; Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Bernal-Mizrachi E; Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine and Miami VA Health Care System, Miami, FL, USA., Alonso LC; Division of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA., MacDonald PE; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada., Johnson JD; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada. James.d.johnson@ubc.ca.

Publikováno v: Nature communications [Nat Commun] 2022 Feb 08; Vol. 13 (1), pp. 735. Date of Electronic Publication: 2022 Feb 08.