Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Marcial Camacho"'
Autor:
Marcial Camacho, Bradley Quade, Thorsten Trimbuch, Junjie Xu, Levent Sari, Josep Rizo, Christian Rosenmund
Publikováno v:
eLife, Vol 10 (2021)
Munc13-1 plays a central role in neurotransmitter release through its conserved C-terminal region, which includes a diacyglycerol (DAG)-binding C1 domain, a Ca2+/PIP2-binding C2B domain, a MUN domain and a C2C domain. Munc13-1 was proposed to bridge
Externí odkaz:
https://doaj.org/article/f74364d8bc6c4f60aedc50002b36330a
Autor:
Marisa M. Brockmann, Fereshteh Zarebidaki, Marcial Camacho, M. Katharina Grauel, Thorsten Trimbuch, Thomas C. Südhof, Christian Rosenmund
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107960- (2020)
Summary: At the presynaptic active zone, action-potential-triggered neurotransmitter release requires that fusion-competent synaptic vesicles are placed next to Ca2+ channels. The active zone resident proteins RIM, RBP, and Munc13 are essential contr
Externí odkaz:
https://doaj.org/article/7763280415ec449685a6a81ebc00a72b
Autor:
Daniela Ivanova, Cordelia Imig, Marcial Camacho, Annika Reinhold, Debarpan Guhathakurta, Carolina Montenegro-Venegas, Michael A. Cousin, Eckart D. Gundelfinger, Christian Rosenmund, Benjamin Cooper, Anna Fejtova
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2444-2459.e7 (2020)
Summary: Compensatory endocytosis of released synaptic vesicles (SVs) relies on coordinated signaling at the lipid-protein interface. Here, we address the synaptic function of C-terminal binding protein 1 (CtBP1), a ubiquitous regulator of gene expre
Externí odkaz:
https://doaj.org/article/8e61db36f3074829adbbc96622133068
Autor:
Marcial Camacho, Jayeeta Basu, Thorsten Trimbuch, Shuwen Chang, Cristina Pulido-Lozano, Shwu-Shin Chang, Irina Duluvova, Masin Abo-Rady, Josep Rizo, Christian Rosenmund
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The interaction between RIM and the C2A domain of Munc13 is known to be required for synaptic vesicle priming. Here the authors show new implications of the C2A domain of Munc13, through its dynamic interaction with RIM, in orchestrating a wide range
Externí odkaz:
https://doaj.org/article/52a5936a1e17420b818768e85afd9042
Autor:
Bradley Quade, Marcial Camacho, Xiaowei Zhao, Marta Orlando, Thorsten Trimbuch, Junjie Xu, Wei Li, Daniela Nicastro, Christian Rosenmund, Josep Rizo
Publikováno v:
eLife, Vol 8 (2019)
Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C1, C2B, MUN and C2C domains of Munc13-1 (C1C2BMUNC2C) bridges the synaptic vesicle and plasma membranes through interactions
Externí odkaz:
https://doaj.org/article/2d55d93b99e24d608ba52b64debdaa37
Autor:
Junjie Xu, Marcial Camacho, Yibin Xu, Victoria Esser, Xiaoxia Liu, Thorsten Trimbuch, Yun-Zu Pan, Cong Ma, Diana R Tomchick, Christian Rosenmund, Josep Rizo
Publikováno v:
eLife, Vol 6 (2017)
Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how the functions of the multiple domains of Munc13–1 are coordinated. The
Externí odkaz:
https://doaj.org/article/482920feddd245e689ecabf30e55ff0b
Autor:
Xiaoxia Liu, Alpay Burak Seven, Marcial Camacho, Victoria Esser, Junjie Xu, Thorsten Trimbuch, Bradley Quade, Lijing Su, Cong Ma, Christian Rosenmund, Josep Rizo
Publikováno v:
eLife, Vol 5 (2016)
Neurotransmitter release requires SNARE complexes to bring membranes together, NSF-SNAPs to recycle the SNAREs, Munc18-1 and Munc13s to orchestrate SNARE complex assembly, and Synaptotagmin-1 to trigger fast Ca2+-dependent membrane fusion. However, i
Externí odkaz:
https://doaj.org/article/1dd724c07e6b482a8142fdf66082425d
Autor:
Boris Bouazza-Arostegui, Marcial Camacho, Marisa M. Brockmann, Sina Zobel, Christian Rosenmund
Publikováno v:
The Journal of Neuroscience. 42:2856-2871
Synaptotagmin-1 (SYT1) is a synaptic vesicle resident protein that interacts via its C2 domain with anionic lipids from the plasma membrane in a calcium-dependent manner to efficiently trigger rapid neurotransmitter (NT) release. In addition, SYT1 ac
Autor:
Marcial Camacho, Christian Rosenmund, Thorsten Trimbuch, Melissa A. Herman, Marisa M Brockmann, Fereshteh Zarebidaki
Publikováno v:
The Journal of Neuroscience
Efficient neurotransmitter release at the presynaptic terminal requires docking of synaptic vesicles to the active zone membrane and formation of fusion-competent synaptic vesicles near voltage-gated Ca2+channels. Rab3-interacting molecule (RIM) is a
Autor:
Annika Reinhold, Christian Rosenmund, Michael A. Cousin, Cordelia Imig, Benjamin H. Cooper, Daniela Ivanova, Debarpan Guhathakurta, Anna Fejtova, Marcial Camacho, Eckart D. Gundelfinger, Carolina Montenegro-Venegas
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2444-2459.e7 (2020)
Cell Reports
Cell reports, 30(7):2444-2459.e7
Ivanova, D, Imig, C, Camacho, M, Reinhold, A, Guhathakurta, D, Montenegro-Venegas, C, Cousin, M A, Gundelfinger, E D, Rosenmund, C, Cooper, B & Fejtova, A 2020, ' CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles ', Cell Reports, vol. 30, no. 7, pp. 2444-2459.e7 . https://doi.org/10.1016/j.celrep.2020.01.079
Cell Reports
Cell reports, 30(7):2444-2459.e7
Ivanova, D, Imig, C, Camacho, M, Reinhold, A, Guhathakurta, D, Montenegro-Venegas, C, Cousin, M A, Gundelfinger, E D, Rosenmund, C, Cooper, B & Fejtova, A 2020, ' CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles ', Cell Reports, vol. 30, no. 7, pp. 2444-2459.e7 . https://doi.org/10.1016/j.celrep.2020.01.079
Summary Compensatory endocytosis of released synaptic vesicles (SVs) relies on coordinated signaling at the lipid-protein interface. Here, we address the synaptic function of C-terminal binding protein 1 (CtBP1), a ubiquitous regulator of gene expres