Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Marcia Machein"'
Autor:
Julia C. Kuehn, Patrick Metzger, Nicolas Neidert, Uta Matysiak, Linda Gräßel, Ulrike Philipp, Sabine Bleul, Thomas Pauli, Julia Falkenstein, Henriette Bertemes, Stepan Cysar, Maria Elena Hess, Anna Verena Frey, Jesús Duque-Afonso, Elisabeth Schorb, Marcia Machein, Jürgen Beck, Oliver Schnell, Nikolas von Bubnoff, Anna L. Illert, Christoph Peters, Tilman Brummer, Marco Prinz, Cornelius Miething, Heiko Becker, Silke Lassmann, Martin Werner, Melanie Börries, Justus Duyster, Dieter H. Heiland, Roman Sankowski, Florian Scherer
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Despite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we explored the feasibility of individual molecular profiling and the efficacy of bioma
Externí odkaz:
https://doaj.org/article/1dc07143d8964d58a48d87e8eab4e848
Autor:
Oliver Oelhke, Waseem Masalha, Ori Staszewski, Nils H. Nicolay, Dieter Henrik Heiland, Pamela Franco, Daniel Delev, Ralf Watzlawick, Gerrit Haaker, Marcia Machein, Oliver Schnell
Publikováno v:
Journal of Neuro-Oncology. 140:385-391
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults with peak incidence in patients older than 65 years. These patients are mostly underrepresented in clinical trials and often undertreated due to concomitant dise
Autor:
Jean Vacher, Hans-Eckart Schaefer, Nadja Osterberg, Karl H. Plate, Soroush Doostkam, Marcia Machein, Napoleone Ferrara, Simone Gaedicke, Gabriele Niedermann, Astrid Weyerbrock
Publikováno v:
Neuro-oncology, vol 18, iss 7
Author(s): Osterberg, Nadja; Ferrara, Napoleone; Vacher, Jean; Gaedicke, Simone; Niedermann, Gabriele; Weyerbrock, Astrid; Doostkam, Soroush; Schaefer, Hans-Eckart; Plate, Karl H; Machein, Marcia Regina | Abstract: BackgroundGlioblastomas are highly
Autor:
Peter Baumgarten, Benjamin Goeppert, Anna-Eva Blank, Joachim P. Steinbach, Katharina Hoffmann, Lisa Mäder, Elke Hattingen, Michel Mittelbronn, Patrick N. Harter, Oliver Bähr, Volker Seifert, Pia S. Zeiner, Kea Franz, Karl H. Plate, Marcia Machein, Maika Dunst
Publikováno v:
Neuro-Oncology. 18:173-183
BACKGROUND A major hallmark of malignant progression in human astrocytomas is the formation of new blood vessels. Antiangiogenic therapy using the anti-vascular endothelial growth factor (VEGF)-antibody bevacizumab leads to increased progression-free
Publikováno v:
Journal of Neuro-Oncology. 121:269-278
Placenta growth factor (PlGF) is a member of vascular endothelial growth factor family which can promote cancer growth by various mechanisms. Placenta growth factor is upregulated in many neoplastic diseases and serum levels of PlGF are increased in
Autor:
Thomas Kretschmer, Wiebke Aumann, Astrid Weyerbrock, Ivan Radovanovic, Karl Lothard Schaller, Veit Rohde, Mario N. Carvi y Nievas, Peter Vajkoczy, Hans Christoph Bock, Dietmar Krex, Haiko Pape, Marcia Machein, Bernhard Meyer, Christian Senft, Marion Rapp, Philippe Schucht, Marcel Seiz-Rosenhagen, Florian Stockhammer, Humberto Tapia-Perez, Florian Ringel, Mehrdad Salehi, Christian Groß, Hans Clusmann, Rüdiger Buchalla, Hans-Georg Höllerhage, Thomas Westermaier, Michael Sabel, Martin Misch, Claudius Thomé, Thomas Schneider, Ralf-Ingo Ernestus, Anke Höllig, Matthias Simon, Jürgen Beck, Petra Wolf, Kea Franz
Publikováno v:
Neuro-Oncology, Vol. 18, No 1 (2016) pp. 96-104
BACKGROUND: While standards for the treatment of newly diagnosed glioblastomas exist, therapeutic regimens for tumor recurrence remain mostly individualized. The role of a surgical resection of recurrent glioblastomas remains largely unclear at prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d2e27742df86e6ef28f38cb9865488
Autor:
Waseem Masalha, Ralf Watzlawick, Marcia Machein, Gerrit Haaker, Nils H. Nicolay, Daniel Delev, Oliver Oelhke, Pamela Franco, Ori Staszewski, Dieter Henrik Heiland, Oliver Schnell
Publikováno v:
Journal of Neuro-Oncology. 140:393-393
Autor:
Sabine Raab, Karl H. Plate, Alexander Scholz, Marcia Machein, Masabumi Shibuya, Thomas Deller, Ekaterini Copanaki, Matthias Heil, Heike Beck
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 69:168-175
Vascular endothelial growth factor receptor 1 (VEGFR-1) is highly expressed in endothelial cells and regulates developmental angiogenesis by acting as a decoy receptor and trapping VEGF-A. Vascular endothelial growth factor receptor 1 is also express
Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors
Publikováno v:
International Journal of Cancer. 125:1771-1777
Despite extensive research, the contribution of bone-marrow-derived endothelial progenitor cells (BM-EPC) to tumor angiogenesis remains controversial. In previous publications, the extent of incorporation of BM-EPCs into the endothelial cell (EC) lay
Publikováno v:
Journal of neuro-oncology. 126(3)
Bevacizumab (BEV) is widely used for treatment of patients with recurrent glioblastoma multiforme (GBM). 1-(2-Chlorethyl)-cyclohexyl-nitrosourea (CCNU, lomustine) monotherapy is an approved chemotherapeutical option for recurrent GBM. Recent evidence