Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Marcia M. Bieber"'
Autor:
Michaela Liedtke, Clare J. Twist, Bruno C. Medeiros, Jason R. Gotlib, Caroline Berube, Marcia M. Bieber, Neelima M. Bhat, Nelson N. Teng, Steven E. Coutre
Publikováno v:
Haematologica, Vol 97, Iss 1 (2012)
Background This phase I trial was conducted to determine the safety and pharmacokinetics of monoclonal antibody 216, a human monoclonal Immunoglobulin M antibody targeting a linear B-cell lactosamine antigen, administered alone and in combination wit
Externí odkaz:
https://doaj.org/article/8bee1241568a4fe3ba60621ca786d70d
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0187222 (2017)
Epithelial Ovarian Cancer (EOC) cells expression of a novel carbohydrate antigen was defined using a human VH4-34 encoded IgM monoclonal antibody (mAb216). MAb216 binds to a poly N-acetyllactosamine epitope expressed on B cells and kills normal and m
Externí odkaz:
https://doaj.org/article/f771d8dea84d4fd59c8ae830a60da3b4
Publikováno v:
Immunological Investigations. 44:400-410
VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell hyperproliferation/dysfunction. One of the autoantigens recognized by VH4-34-encoded antibodies are branched/linear pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c12ec98d1b3f3ca178b23d69b707a1
https://doi.org/10.3109/08820139.2015.1015682
https://doi.org/10.3109/08820139.2015.1015682
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0187222 (2017)
PLoS ONE
PLoS ONE
Epithelial Ovarian Cancer (EOC) cells expression of a novel carbohydrate antigen was defined using a human VH4-34 encoded IgM monoclonal antibody (mAb216). MAb216 binds to a poly N-acetyllactosamine epitope expressed on B cells and kills normal and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f36c59f76d4f34b447501378a5fd4d2
http://europepmc.org/articles/PMC5739388?pdf=render
http://europepmc.org/articles/PMC5739388?pdf=render
Publikováno v:
Gynecologic Oncology. 154:e28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90d7ec581dcbc05be43d7bced0570181
https://doi.org/10.1016/j.ygyno.2019.03.228
https://doi.org/10.1016/j.ygyno.2019.03.228
Autor:
Nelson N.H. Teng, Marcia M. Bieber, Michaela Liedtke, Jason Gotlib, Bruno C. Medeiros, Caroline Berube, Steven Coutre, Clare J. Twist, Neelima M. Bhat
Publikováno v:
Haematologica. 97:30-37
Background This phase I trial was conducted to determine the safety and pharmacokinetics of monoclonal antibody 216, a human monoclonal Immunoglobulin M antibody targeting a linear B-cell lactosamine antigen, administered alone and in combination wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3bc7681f6e647461fc875543475374
https://doi.org/10.3324/haematol.2011.045997
https://doi.org/10.3324/haematol.2011.045997
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(11)
B cell binding and cytotoxicity by human VH4-34–encoded Abs of the IgM isotype has been well documented. A VH4-34-IgM has recently shown a favorable early response in a phase 1 trial for treatment of B cell acute lymphoblastic leukemia. Although it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e082b371c0c026b0c7c2be658b8c7cca
https://pubmed.ncbi.nlm.nih.gov/26503955
https://pubmed.ncbi.nlm.nih.gov/26503955
Autor:
Ronald F van Vollenhoven, Marcia M. Bieber, Neelima M. Bhat, Yi-Shing Leu, Yuh-Cheng Yang, Nelson N.H. Teng
Publikováno v:
Human Antibodies. 13:63-68
The VH4-34 represents an unusual Ig heavy chain variable region gene given that it is conserved and overexpressed despite its autoreactivity. Besides RBC 'I/i' recognition, a subset of VH4-34 encoded Igs bind and kill human B-lymphocytes via interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ed260b9ecc711ab0ccc0defe6b55a36
https://doi.org/10.3233/hab-2004-13302
https://doi.org/10.3233/hab-2004-13302
Publikováno v:
Critical Reviews in Oncology/Hematology. 39:59-68
Our previous studies have shown that mAbs derived from the human V4-34 gene bind and kill human B-lymphocytes via membrane disruption. This study demonstrates the cytotoxicity of two V4-34 encoded mAbs, 216 and Z2D2, towards human B-cell lymphoma. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fc6619a6dc40941782894996f31c97
https://doi.org/10.1016/s1040-8428(01)00104-4
https://doi.org/10.1016/s1040-8428(01)00104-4
Publikováno v:
Human Antibodies. 8:146-150
To evaluate the role of B-1 cells and polyreactive autoantibodies in the development of adult immune repertoire, it is necessary to assess their immunoglobulin heavy chain variable-gene usage. We thus screened 28 independently derived human polyreact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27e300c40f490894d227cd1e3f46b86d
https://doi.org/10.3233/hab-1997-8306
https://doi.org/10.3233/hab-1997-8306