Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marcia L.E. MacDonald"'
Autor:
Marcia L.E. MacDonald, Roshni R. Singaraja, Nagat Bissada, Piers Ruddle, Russell Watts, Joanna M. Karasinska, William T. Gibson, Catherine Fievet, Jean E. Vance, Bart Staels, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 217-229 (2008)
A combination of the interrelated metabolic risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the “metabolic syndrome,” is known to increase the risk of developing cardiovascular disease and diabetes. St
Externí odkaz:
https://doaj.org/article/17a351d051934869b33eaae8b8be0504
Autor:
Alan D. Attie, Yannick Hamon, Angela R. Brooks-Wilson, Mark P. Gray-Keller, Marcia L.E. MacDonald, Veronique Rigot, Angie Tebon, Lin-Hua Zhang, Jacob D. Mulligan, Roshni R. Singaraja, J.James Bitgood, Mark E. Cook, John J.P. Kastelein, Giovanna Chimini, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 10, Pp 1610-1617 (2002)
The Wisconsin hypoalpha mutant (WHAM) chicken has a >90% reduction in plasma HDL due to hypercatabolism by the kidney of lipid-poor apoA-I. The WHAM chickens have a recessive white skin phenotype caused by a single-gene mutation that maps to the chic
Externí odkaz:
https://doaj.org/article/cf7ebaa088c742f99091cc5643fa3af9
Autor:
Sandra L. Babich, Pavlos Pissios, Michael R. Hayden, Marcia L.E. MacDonald, William T. Gibson, Eleftheria Maratos-Flier, Melissa B. Glier
Publikováno v:
Peptides. 31:123-129
We propose that deletion of pro-melanin-concentrating hormone (pMCH) would increase energy expenditure and further improve glucose tolerance in mice lacking stearoyl-coA desaturase-1 (SCD1). To test our hypothesis, we bred and metabolically challenge
Autor:
Piers Ruddle, Michael R. Hayden, Bart Staels, Russell Watts, Catherine Fievet, Roshni R. Singaraja, Jean E. Vance, William T. Gibson, Nagat Bissada, Marcia L.E. MacDonald, Joanna M. Karasinska
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 217-229 (2008)
A combination of the interrelated metabolic risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the "metabolic syndrome," is known to increase the risk of developing cardiovascular disease and diabetes. Stearo
Autor:
Mark E. Samuels, Marcia L.E. MacDonald, Barkur S. Shastry, Julie MacFarlane, Y P Goldberg, Michael T. Trese
Publikováno v:
Clinical Genetics. 67:363-366
Autor:
Michael R. Hayden, Y. Paul Goldberg, A. Hoskin-Mott, Laird C. Sheldahl, Michael T. Trese, Marcia L.E. MacDonald, Marie-Pierre Dubé, Randall T. Moon, Simon N. Pimstone, Mark E. Samuels, J Zeisler, Lin-Hua Zhang, B. Zheng, Ajamete Kaykas, Barkur S. Shastry, Lee Siebert, Duane L. Guernsey, Johane M Robitaille, Roshni R. Singaraja
Publikováno v:
Nature Genetics. 32:326-330
Familial exudative vitreoretinopathy (FEVR) is a hereditary ocular disorder characterized by a failure of peripheral retinal vascularization. Loci associated with FEVR map to 11q13-q23 (EVR1; OMIM 133780, ref. 1), Xp11.4 (EVR2; OMIM 305390, ref. 2) a
Publikováno v:
Gene Therapy. 6:922-930
Herpes simplex virus (HSV) is a new platform for gene therapy. We cloned the human herpesvirus HSV-1 strain F genome into a bacterial artificial chromosome (BAC) and adapted chromosomal gene replacement technology to manipulate the viral genome. This
Absence of stearoyl-CoA desaturase-1 (SCD1) in mice leads to chronic inflammation of the skin and increased susceptibility to atherosclerosis, while also increasing plasma inflammatory markers. A recent report suggested that SCD1 deficiency also incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b817a9e5ae4bbdded51b50b9da441
Autor:
Michael R. Hayden, Reeni B. Hildebrand, Bruce M. McManus, Catherine Fievet, M. John Chapman, Piers Ruddle, Mahmoud A. Pouladi, Bart Staels, Marcia L.E. MacDonald, Nagat Bissada, Anatol Kontush, Miranda Van Eck, Hala Hussein, Brian W. Wong, Theo J.C. Van Berkel
Objective— Absence of stearoyl-CoA desaturase-1 (SCD1) in mice reduces plasma triglycerides and provides protection from obesity and insulin resistance, which would be predicted to be associated with reduced susceptibility to atherosclerosis. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7db0b0163e979557c07363a0e97df5
Autor:
E Toscano, Generoso Andria, C Young, BG Sibley, Mark E. Samuels, Marcia L.E. MacDonald, B Payne, HB Younghusband, JH Dimon, G Donaldson, Sakiat Hossain, A Duff, Maryanne Mattice, Julie MacFarlane, Jay Thompson, D Bowsher, Simon N. Pimstone, E Boltshauser, Hayden, R Fraser, Robin Sherrington, Elizabeth Ives, J Kerdraon, Y P Goldberg, GA Grinspan, Roger C. Green, Terry D Pape, C Radomski, J Cox, M-P Dubé
Publikováno v:
Clinical genetics. 71(4)
Congenital indifference to pain (CIP) is a rare condition in which patients have severely impaired pain perception, but are otherwise essentially normal. We identified and collected DNA from individuals from nine families of seven different nationali