Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Marcia E. Newcomer"'
Autor:
Friedemann Börner, Simona Pace, Paul M. Jordan, Jana Gerstmeier, Mario Gomez, Antonietta Rossi, Nathaniel C. Gilbert, Marcia E. Newcomer, Oliver Werz
Publikováno v:
Advanced Science, Vol 10, Iss 6, Pp n/a-n/a (2023)
Abstract Specialized pro‐resolving mediators (SPM), primarily produced in innate immune cells, exert crucial bioactions for resolving inflammation. Among various lipoxygenases (LOX), 15‐LOX‐1 is key for SPM biosynthesis, but cellular activation
Externí odkaz:
https://doaj.org/article/f7a65d27906145a490b7a46ae1390446
Publikováno v:
Annual Review of Pharmacology and Toxicology. 63:407-428
Leukotrienes are potent immune-regulating lipid mediators with patho-genic roles in inflammatory and allergic diseases, particularly asthma. These autacoids also contribute to low-grade inflammation, a hallmark of cardiovascular, neurodegenerative, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7d3a7ea6061aca6fcbbe4f49a5d368
https://doi.org/10.1146/annurev-pharmtox-051921-085014
https://doi.org/10.1146/annurev-pharmtox-051921-085014
Autor:
Friedemann, Börner, Simona, Pace, Paul M, Jordan, Jana, Gerstmeier, Mario, Gomez, Antonietta, Rossi, Nathaniel C, Gilbert, Marcia E, Newcomer, Oliver, Werz
Publikováno v:
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
Specialized pro-resolving mediators (SPM), primarily produced in innate immune cells, exert crucial bioactions for resolving inflammation. Among various lipoxygenases (LOX), 15-LOX-1 is key for SPM biosynthesis, but cellular activation principles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d02566c2074a89b8448042831aadb87
https://pubmed.ncbi.nlm.nih.gov/36567268
https://pubmed.ncbi.nlm.nih.gov/36567268
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187169 (2017)
Antifreeze proteins (AFPs) enhance the survival of organisms inhabiting cold environments by affecting the formation and/or structure of ice. We report the crystal structure of the first multi-domain AFP that has been characterized. The two ice bindi
Externí odkaz:
https://doaj.org/article/37d21bd5828a473a8b0a67fb1ce2a3da
Autor:
Eden M. Gallegos, Tanner D. Reed, Forge A. Mathes, Nelson V. Guevara, David B. Neau, Wei Huang, Marcia E. Newcomer, Nathaniel C. Gilbert
Publikováno v:
Journal of Biological Chemistry. 298:102282
The synthesis of proinflammatory leukotrienes implicated in asthma, allergic rhinitis, and atherosclerosis is initiated by the enzyme 5-lipoxygenase (5-LOX). The crystal structure of human Stable-5-LOX revealed a conformation where the catalytic iron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1571ceed409cf31b7305de4d2a2581d5
https://doi.org/10.1016/j.jbc.2022.102282
https://doi.org/10.1016/j.jbc.2022.102282
Autor:
Paul M. Jordan, Jana Gerstmeier, Ulrike Garscha, Marcia E. Newcomer, Erin E. Schexnaydre, Oliver Werz
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864:543-551
Leukotrienes (LT) are lipid mediators of the inflammatory response that play key roles in diseases such as asthma and atherosclerosis. The precursor leukotriene A(4) (LTA(4)) is synthesized from arachidonic acid (AA) by 5-lipoxygenase (5-LOX), a memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0d428e2d386dea1db88f47a0fa463e
https://doi.org/10.1016/j.bbalip.2018.09.011
https://doi.org/10.1016/j.bbalip.2018.09.011
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9f6a923c480ecacb292c17550e3e1c4
https://doi.org/10.1016/b978-0-12-809633-8.21358-7
https://doi.org/10.1016/b978-0-12-809633-8.21358-7
Autor:
Paul M. Jordan, Oliver Werz, Christian Kretzer, Kehong Zhang, Friedemann Börner, Dagmar Fischer, Robert K. Hofstetter, Xinchun Chen, Marianna Potenza, Wenfei Wang, Simona Pace, Nathaniel C. Gilbert, Jana Gerstmeier, Antonietta Rossi, Rossella Bilancia, Marcia E. Newcomer, Stefan Lorkowski
The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook. F. effectively ameliorates inflammation with potential as therapeutics for inflammatory diseases. However, the molecular mechanisms underlying the anti-infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fbc3e9ff67f054c31088293a16e14b
http://hdl.handle.net/11588/851265
http://hdl.handle.net/11588/851265
Autor:
Matthew P. Jacobson, Nathan C. Gilbert, Wan-Chen Tsai, Adam Yasgar, Chakrapani Kalyanaraman, Michelle Armstrong, Melissa Standley, Anthony T. Iavarone, Amanda Ohler, David B. Neau, Ganesha Rai, Adam R. Offenbacher, Marcia E. Newcomer, Phillip Crews, Steve Perry, Anton Simeonov, Hsiau-Wei Lee, Ajit Jadhav, Theodore R. Holman
Publikováno v:
Bioorg Med Chem
Human epithelial 15-lipoxygenase-2 (h15-LOX-2, ALOX15B) is expressed in many tissues and has been implicated in atherosclerosis, cystic fibrosis and ferroptosis. However, there are few reported potent/selective inhibitors that are active ex vivo. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3912b067b088331e3e6d433d005fa18c
https://doi.org/10.1016/j.bmc.2021.116349
https://doi.org/10.1016/j.bmc.2021.116349
Autor:
Marcia E. Newcomer
On the fiftieth anniversary of the discovery of the Ser-His-Asp catalytic triad, perhaps the most unusual variation on the textbook classic is described: An incomplete catalytic triad in a hydrolase is rescued by a chloride ion (Fig. 1). Structural a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02e79da50368e9ca05156e9a72f0959
https://europepmc.org/articles/PMC6663875/
https://europepmc.org/articles/PMC6663875/