Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infection.

Autor: Paulo D'Amora, Ismael Dale C G Silva, Maria Auxiliadora Budib, Ricardo Ayache, Rafaela Moraes Siufi Silva, Fabricio Colacino Silva, Robson Mateus Appel, Saturnino Sarat Júnior, Henrique Budib Dorsa Pontes, Ana Carolina Alvarenga, Emilli Carvalho Arima, Wellington Galhano Martins, Nakal Laurenço F Silva, Ricardo Sobhie Diaz, Marcia B Salzgeber, Anton M Palma, Steven S Evans, Robert A Nagourney

Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0259909 (2021)

This study investigated the association between COVID-19 infection and host metabolic signatures as prognostic markers for disease severity and mortality. We enrolled 82 patients with RT-PCR confirmed COVID-19 infection who were classified as mild, m

Externí odkaz: https://doaj.org/article/2d6f9073a84446dca68372ebde0279bf

Platinum resistance in gynecologic malignancies: Response, disease free and overall survival are predicted by biochemical signature: A metabolomic analysis.

Autor: D'Amora P; Molecular Gynecology and Metabolomics Lab, Gynecology Department, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), Rua Pedro de Toledo, 781 - 4o. andar frente, 04039-032 São Paulo, SP, Brazil; Nagourney Cancer Institute, 750 East 29th Street, 90806 Long Beach, CA, USA; Metabolomycs, Inc., 750 East 29th Street, 90806 Long Beach, CA, USA. Electronic address: d.amora@unifesp.br., Silva IDCG; Molecular Gynecology and Metabolomics Lab, Gynecology Department, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), Rua Pedro de Toledo, 781 - 4o. andar frente, 04039-032 São Paulo, SP, Brazil; Metabolomycs, Inc., 750 East 29th Street, 90806 Long Beach, CA, USA., Tewari KS; Memorial Medical Center of Long Beach, Todd Cancer Institute, 2810 Long Beach Blvd, Long Beach 90806, CA, USA; Department of Obstetrics and Gynecology, University of California Irvine (UCI) School of Medicine, 101 The City Drive South, Orange 92868, CA, USA., Bristow RE; Memorial Medical Center of Long Beach, Todd Cancer Institute, 2810 Long Beach Blvd, Long Beach 90806, CA, USA; Department of Obstetrics and Gynecology, University of California Irvine (UCI) School of Medicine, 101 The City Drive South, Orange 92868, CA, USA., Cappuccini F; Memorial Medical Center of Long Beach, Todd Cancer Institute, 2810 Long Beach Blvd, Long Beach 90806, CA, USA; Department of Obstetrics and Gynecology, University of California Irvine (UCI) School of Medicine, 101 The City Drive South, Orange 92868, CA, USA., Evans SS; Nagourney Cancer Institute, 750 East 29th Street, 90806 Long Beach, CA, USA; Metabolomycs, Inc., 750 East 29th Street, 90806 Long Beach, CA, USA., Salzgeber MB; Molecular Gynecology and Metabolomics Lab, Gynecology Department, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), Rua Pedro de Toledo, 781 - 4o. andar frente, 04039-032 São Paulo, SP, Brazil., Addis-Bernard PJ; Nagourney Cancer Institute, 750 East 29th Street, 90806 Long Beach, CA, USA., Palma AM; Institute for Clinical and Translational Science (ICTS), University of California Irvine (UCI), 843 Health Science Rd, Irvine 92697, CA, USA., Marchioni DML; Nutrition Department, School of Public Health, University of São Paulo School of Medicine (FMUSP), Av. Dr Arnaldo 715, 01246-904 São Paulo, SP, Brazil., Carioca AAF; Nutrition Department, University of Fortaleza (UNIFOR), Av. Washington Soares, 1321, 60811-905 Fortaleza, CE, Brazil., Penner KR; Kaiser Permanente South Bay Medical Center, 25825 S Vermont Ave, Harbor City 90710, CA, USA., Alldredge J; UCHealth Cancer Care - Anschutz Medical Campus, University of Colorado Cancer Center, 1665 Aurora Court, Aurora 80045, CO, USA., Longoria T; Scripps Clinic John R. Anderson V Medical Pavilion, 9898 Genesee Ave, La Jolla 92037, CA, USA., Nagourney RA; Nagourney Cancer Institute, 750 East 29th Street, 90806 Long Beach, CA, USA; Metabolomycs, Inc., 750 East 29th Street, 90806 Long Beach, CA, USA; Memorial Medical Center of Long Beach, Todd Cancer Institute, 2810 Long Beach Blvd, Long Beach 90806, CA, USA; Department of Obstetrics and Gynecology, University of California Irvine (UCI) School of Medicine, 101 The City Drive South, Orange 92868, CA, USA.

Publikováno v: Gynecologic oncology [Gynecol Oncol] 2021 Oct; Vol. 163 (1), pp. 162-170. Date of Electronic Publication: 2021 Aug 24.