Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Marcia A Munoz"'
Autor:
Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, Mark P Hodson, Shuting Sun, Frank H Ebetino, David R Croucher, Philip M Hansbro, Jacqueline R Center, Michael J Rogers
Publikováno v:
eLife, Vol 10 (2021)
Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to r
Externí odkaz:
https://doaj.org/article/efd2366c282f45e0a4b6b5d87db2968d
Autor:
Michael J Rogers, Marcia A Munoz
Publikováno v:
eLife, Vol 7 (2018)
Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
Externí odkaz:
https://doaj.org/article/7f37ee7d28e24f24b8e187fb8fd1a30d
Autor:
Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma K. Fletcher, Esther Kristianto, Mark P. Hodson, Seán I. O’Donoghue, Sandeep Kaur, Robert Brink, David G. Zahra, Elissa K. Deenick, Kristen A. Perry, Avril A.B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)
Mevalonate kinase deficiency (MKD) is characterized by recurrent fevers and flares of systemic inflammation, caused by biallelic loss-of-function mutations in MVK. The underlying disease mechanisms and triggers of inflammatory flares are poorly under
Externí odkaz:
https://doaj.org/article/21b5b88799f3482d9c5c720c2d6c2ea8
Autor:
Marcia A. Munoz, Julie Jurczyluk, Anna Simon, Pravin Hissaria, Rob J. W. Arts, David Coman, Christina Boros, Sam Mehr, Michael J. Rogers
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase. Deficiency of this enzyme decreases the synthesis
Externí odkaz:
https://doaj.org/article/27842b62c9b644a9a479322c9f12f919
The formation of a new vascular network by angiogenesis is a key driver in tumor growth and metastasis, making this an attractive therapeutic target. Different strategies are being developed to either prevent tumor angiogenesis or disrupt the tumor v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cc0ba47857d1c04ab60794b5ff7946
https://doi.org/10.1158/1535-7163.c.6531890
https://doi.org/10.1158/1535-7163.c.6531890
Video Legends.Supplementary Table 1. Supplementary Figure 5 from ENMD-1198, a New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting Properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b47990a366b8a69dc3e4c5b93c7c57b
https://doi.org/10.1158/1535-7163.22485311
https://doi.org/10.1158/1535-7163.22485311