Zobrazeno 1 - 3 of 3 pro vyhledávání: '"Marcia Heron"'
1
Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies
Autor: Francois Pognan, Min Dong, Armin Wolf, Ursula Junker, Jeffrey Tsao, David Ledieu, Ulrich W. Laengle, Danielle Roman, Anja Nussher, Olivier Grenet, Christian Trendelenburg, Gilles-Jacques Riviere, Philippe Couttet, Estelle Marrer, Elke Persohn, Marcia Heron, Daniel Robert Roth
Publikováno v: Leukemia Research. 34:1180-1188
Cytotoxic concentrations of imatinib mesylate (10–50 μM) were required to trigger markers of apoptosis and endoplasmic reticulum stress response in neonatal rat ventricular myocytes and fibroblasts, with no significant differences observed between
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122195b8ee064e0a81eceec4d845fd07
https://doi.org/10.1016/j.leukres.2010.01.004
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2
Preclinical evaluation of potential nilotinib cardiotoxicity
Autor: Francois Pognan, Elke Persohn, Estelle Marrer, Wei Zhou, Philippe Couttet, Marcia Heron, Ursula Junker, Olivier Grenet, Armin Wolf, David Ledieu, Jeffrey Tsao, Danielle Roman, Andreas Mahl, Min Dong
Publikováno v: Leukemia research. 35(5)
In vitro, concentrations ≥ 10 μM of nilotinib were needed to induce markers of cytotoxicity, apoptosis, and endoplasmic reticulum stress in both neonatal rat ventricular myocytes, a putative target tissue, and non-target heart fibroblasts, indicat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeb9e69882e386b86b3f552f8eee618
https://pubmed.ncbi.nlm.nih.gov/21333353
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