CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.

Autor: Martin J Siemerink, Michael R Hughes, Marchien G Dallinga, Tomek Gora, Jessica Cait, Ilse M C Vogels, Bahar Yetin-Arik, Cornelis J F Van Noorden, Ingeborg Klaassen, Kelly M McNagny, Reinier O Schlingemann

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0157902 (2016)

The sialomucins CD34 and podocalyxin (PODXL) are anti-adhesive molecules expressed at the luminal membrane of endothelial cells of small blood vessels and facilitate vascular lumen formation in the developing mouse aorta. CD34 transcript and protein

Externí odkaz: https://doaj.org/article/3b7a7256c5dd469f8d30bac7bd0a8748

Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression.

Autor: Margriet M Palm, Marchien G Dallinga, Erik van Dijk, Ingeborg Klaassen, Reinier O Schlingemann, Roeland M H Merks

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0159478 (2016)

Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an

Externí odkaz: https://doaj.org/article/4bfb1322ee1047a589ddd3b828fea4e3

The Role of Heparan Sulfate and Neuropilin 2 in VEGFA Signaling in Human Endothelial Tip Cells and Non-Tip Cells during Angiogenesis In Vitro

Autor: Cornelis J.F. Van Noorden, Marchien G. Dallinga, Ingeborg Klaassen, Alinda W. M. Schimmel, Geesje M. Dallinga-Thie, Reinier O. Schlingemann, Yasmin Habani

Publikováno v: Cells, Vol 10, Iss 926, p 926 (2021)
Cells
Volume 10
Issue 4
Cells, 10(4):926. MDPI Multidisciplinary Digital Publishing Institute

During angiogenesis, vascular endothelial growth factor A (VEGFA) regulates endothelial cell (EC) survival, tip cell formation, and stalk cell proliferation via VEGF receptor 2 (VEGFR2). VEGFR2 can interact with VEGFR2 co-receptors such as heparan su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15de7ef8360d30b6578f066901d705
https://www.mdpi.com/2073-4409/10/4/926

Computational screening of tip and stalk cell behavior proposes a role for apelin signaling in sprout progression

Autor: Marchien G. Dallinga, Reinier O. Schlingemann, Erik van Dijk, Roeland M. H. Merks, Ingeborg Klaassen, Margriet Palm

Publikováno v: PLoS ONE, 11(11)
PLoS ONE, Vol 11, Iss 11, p e0159478 (2016)
Palm, M M, Dallinga, M G, van Dijk, E, Klaassen, I, Schlingemann, R O & Merks, R M H 2016, ' Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression ', PLoS ONE, vol. 11, no. 11, pp. e0159478 . https://doi.org/10.1371/journal.pone.0159478
PLoS ONE, 11(11). Public Library of Science
PLoS ONE
PLOS ONE
PLOS ONE, 11(11), e0159478

Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5ad129f713bef5630d0d698b280849
https://ir.cwi.nl/pub/25095

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Autor: Reinier O. Schlingemann, Andrea Weiss, Li Shen, Tse J. Wong, Roberto Pili, Marchien G. Dallinga, Olivier Dormond, Chih-Ming Ho, Arjan W. Griffioen, Hubert van den Bergh, Paul J. Dyson, Judy R. van Beijnum, Patrycja Nowak-Sliwinska, Xianting Ding, Ieong Wong, Robert H. Berndsen

Publikováno v: Angiogenesis, vol. 18, no. 3, pp. 233-244
Weiss, A, Ding, X T, van Beijnum, J R, Wong, I, Wong, T J, Berndsen, R H, Dormond, O, Dallinga, M, Shen, L, Schlingemann, R O, Pili, R, Ho, C M, Dyson, P J, van den Bergh, H, Griffioen, A W & Nowak-Sliwinska, P 2015, ' Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer ', Angiogenesis, vol. 18, no. 3, pp. 233-244 . https://doi.org/10.1007/s10456-015-9462-9
Angiogenesis, 18(3), 233-244. Springer Netherlands
Angiogenesis
Weiss, A; Ding, X; van Beijnum, JR; Wong, I; Wong, TJ; Berndsen, RH; et al.(2015). Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer. Angiogenesis, 18(3), 233-244. doi: 10.1007/s10456-015-9462-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1f05g517

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) techn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1c08796c4ec291536a1f867989f3ee
https://serval.unil.ch/notice/serval:BIB_0F969B733169