Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases.

Autor: Molina R; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3-B, 2200 Copenhagen, Denmark., Garcia-Martin R; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3-B, 2200 Copenhagen, Denmark., López-Méndez B; The Novo Nordisk Foundation Center for Protein Research, Protein Structure & Function Programme, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Jensen ALG; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3-B, 2200 Copenhagen, Denmark., Ciges-Tomas JR; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3-B, 2200 Copenhagen, Denmark., Marchena-Hurtado J; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3-B, 2200 Copenhagen, Denmark., Stella S; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3-B, 2200 Copenhagen, Denmark., Montoya G; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3-B, 2200 Copenhagen, Denmark.; The Novo Nordisk Foundation Center for Protein Research, Protein Structure & Function Programme, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Oct 28; Vol. 50 (19), pp. 11199-11213.

The Historical Evolution and Significance of Multiple Sequence Alignment in Molecular Structure and Function Prediction.

Autor: Zhang, Chenyue¹ (AUTHOR) 1120220056@mail.nankai.edu.cn, Wang, Qinxin² (AUTHOR) wangqinxin.wang@gmail.com, Li, Yiyang¹ (AUTHOR) 2120220137@mail.nankai.edu.cn, Teng, Anqi³ (AUTHOR) ateng201@connect.hkust-gz.edu.cn, Hu, Gang¹ (AUTHOR) huggs@nankai.edu.cn, Wuyun, Qiqige⁴ (AUTHOR) wuyunqiq@msu.edu, Zheng, Wei^1,5 (AUTHOR) wuyunqiq@msu.edu

Publikováno v: Biomolecules (2218-273X). Dec2024, Vol. 14 Issue 12, p1531. 37p.

Enhancing the reverse transcriptase function in Taq polymerase via AI-driven multiparametric rational design.

Autor: Tomilova, Yulia E., Russkikh, Nikolay E., Yi, Igor M., Shaburova, Elizaveta V., Tomilov, Viktor N., Pyrinova, Galina B., Brezhneva, Svetlana O., Tikhonyuk, Olga S., Gololobova, Nadezhda S., Popichenko, Dmitriy V., Arkhipov, Maxim O., Bryzgalov, Leonid O., Brenner, Evgeniy V., Artyukh, Anastasia A., Shtokalo, Dmitry N., Antonets, Denis V., Ivanov, Mikhail K.

Publikováno v: Frontiers in Bioengineering & Biotechnology; 2024, p1-21, 21p

The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease.

Autor: Binder, Sophie C, Schneberger, Niels, Schmitz, Maximilian, Engeser, Marianne, Geyer, Matthias, Rouillon, Christophe, Hagelueken, Gregor

Publikováno v: Nucleic Acids Research; 9/23/2024, Vol. 52 Issue 17, p10520-10532, 13p

Genomic Distribution of Pro-Virulent cpdB -like Genes in Eubacteria and Comparison of the Enzyme Specificity of CpdB-like Proteins from Salmonella enterica , Escherichia coli and Streptococcus suis.

Autor: Ribeiro, João Meireles¹ (AUTHOR), Canales, José¹ (AUTHOR), Costas, María Jesús¹ (AUTHOR), Cabezas, Alicia¹ (AUTHOR), Pinto, Rosa María¹ (AUTHOR), García-Díaz, Miguel² (AUTHOR), Martín-Cordero, Paloma³ (AUTHOR), Cameselle, José Carlos¹ (AUTHOR) camselle@unex.es

Publikováno v: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p4150. 24p.