Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents.

Autor: Roa P; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA., Foglizzo V; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA., Harada G; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Repetto M; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Oncology and Haemato-Oncology, University of Milan, 20133, Milan, Italy., Kulick A; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Marchena M; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA., Auwardt S; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA., Sayed Ahmed S; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA., Bremer NV; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA., Yang SR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Feng Y; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA.; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA., Zhou C; InnoCare Pharma Limited, Beijing, China., Kong N; InnoCare Pharma Limited, Beijing, China., Liang R; InnoCare Pharma Limited, Beijing, China., Xu H; InnoCare Pharma Limited, Beijing, China., Zhang B; InnoCare Pharma Limited, Beijing, China., Bardelli A; Department of Oncology, Molecular Biotechnology Center, University of Torino, Torino, Italy.; IFOM-ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Toska E; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD, USA., Ventura A; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Drilon A; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Cocco E; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA. exc2752@miami.edu.; Sylvester Comprehensive Cancer Center (SCCC), Miami, FL, USA. exc2752@miami.edu.

Publikováno v: British journal of cancer [Br J Cancer] 2024 Aug; Vol. 131 (3), pp. 601-610. Date of Electronic Publication: 2024 Jun 20.

Deciphering the Role of POLYCOMB REPRESSIVE COMPLEX1 Variants in Regulating the Acquisition of Flowering Competence in Arabidopsis

Autor: Picó, Sara, Ortiz-Marchena, M. Isabel, Merini, Wiam, Calonje, Myriam

Publikováno v: Plant Physiology, 2015 Aug 01. 168(4), 1286-1297.

Externí odkaz: https://www.jstor.org/stable/24805537

Aptamers to remyelinate Multiple Sclerosis: effects of ApTOLL© treatment in preclinical models and detection of mechanisms in human samples

Autor: Fernández-Gómez, B., Marchena, M., Tocha, I., Gómez-Martín, P., Piñeiro, D., Hernández-Jiménez, M., Castro Soubriet, Fernando de

Comunicación presentada a Fens Forum 2022 en París (Francia)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1106::57d184c1c8ceee119b2140ff78c09746
http://hdl.handle.net/10261/288989

Kinetic study of the oxidation of [Fe(CN) 6] 4− by [Co(NH 3) 4pzCO 2] 2+ and [formula omitted] in the presence of the tripodal ligand Tren Aminopropil

Autor: García-España, E., Sornosa-Ten, A., Albelda, M.T., Sánchez, F., Marchena, M.

Publikováno v: In Chemical Physics Letters 2011 505(4):112-116

Non-productive angiogenesis disassembles A ss plaque-associated blood vessels

Autor: Alvarez-Vergara M, Rosales-Nieves A, March-Diaz R, Rodriguez-Perinan G, Lara-Urena N, San Luis C, Sanchez-Garcia M, Martin-Bornez M, Gomez-Galvez P, Vicente-Munuera P, Fernandez-Gomez B, Marchena M, Bullones-Bolanos A, Davila J, Gonzalez-Martinez R, Trillo-Contreras J, Sanchez-Hidalgo A, del Toro R, Scholl F, Herrera E, Trepel M, Korbelin J, Escudero L, Villadiego J, Echevarria M, de Castro F, Gutierrez A, Rabano A, Vitorica J, Pascual A

Publikováno v: NATURE COMMUNICATIONS
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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The human Alzheimer's disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around A ss plaques. Here we demonstrate that angiogenesis is started near A ss plaques in both AD mouse models and hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::82e8c0df034ef689b954221e24dbe8bc
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8650