Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marcelo de Campos-Nebel"'
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12489 (2010)
Topoisomerase II (Top2) is a nuclear enzyme involved in several metabolic processes of DNA. Chemotherapy agents that poison Top2 are known to induce persistent protein-mediated DNA double strand breaks (DSB). In this report, by using knock down exper
Externí odkaz:
https://doaj.org/article/fb5a48d8eca540629db097f43f0213b2
Autor:
Verónica Inés Landoni, Jose R. Pittaluga, Agostina Carestia, Luis Alejandro Castillo, Marcelo de Campos Nebel, Daiana Martire-Greco, Federico Birnberg-Weiss, Mirta Schattner, Pablo Schierloh, Gabriela C. Fernández
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in the pediatric population. The etiology of HUS is linked to Gram-negative, Shiga toxin (Stx)-producing enterohemorrhagic bacterial infections. While the effect of Stx i
Externí odkaz:
https://doaj.org/article/5d469fb269ae4e7ea7591e039c21b6d8
Publikováno v:
Chromosome Research. 30:459-476
ATM and DNA-PKcs coordinate the DNA damage response at multiple levels following the exposure to chemotherapy. The Topoisomerase II poison etoposide (ETO) is an effective chemotherapeutic agent that induces DNA double-strand breaks (DSB), but it is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7e5414cd53cc444e56c38f5eecc99e
https://doi.org/10.1007/s10577-022-09700-w
https://doi.org/10.1007/s10577-022-09700-w
Autor:
Verónica I Landoni, Pablo Schierloh, Marcelo de Campos Nebel, Gabriela C Fernández, Cecilia Calatayud, María J Lapponi, Martín A Isturiz
Publikováno v:
PLoS Pathogens, Vol 8, Iss 3, p e1002632 (2012)
The hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia and renal dysfunction. The typical form of HUS is generally associated with infections by Gram-negative Shiga toxin (Stx)-producing Escherichia coli (STEC). En
Externí odkaz:
https://doaj.org/article/30c767b504974d0b827af7bdc22818a8
Autor:
Daiana Martire-Greco, María Belén Vecchione, Luis A. Castillo, Mónica Vermeulen, Gabriela C. Fernández, Marcelo de Campos-Nebel, Marlina Córdoba Moreno, Verónica Inés Landoni, Roberto Meiss, Nahuel Rodriguez-Rodrigues
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
All-trans-Retinoic Acid (ATRA) is a derivative of vitamin A with anti-proliferative properties. Endotoxin shock and subsequent immunosuppression (IS) by lipopolysaccharide (LPS) stimulates myelopoiesis with expansion of myeloid-derived suppressor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443ce63183458a986c7ca1782e99626e
https://doi.org/10.1097/shk.0000000000000812
https://doi.org/10.1097/shk.0000000000000812
Publikováno v:
Cytometry Part A. 89:852-860
Topoisomerase II (Top2) is an important target for anticancer therapy. A variety of drugs that poison Top2, including several epipodophyllotoxins, anthracyclines, and anthracenediones, are widely used in the clinic for both hematologic and solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694fe3c1b7ab79ab91a396ccb07940c4
https://doi.org/10.1002/cyto.a.22919
https://doi.org/10.1002/cyto.a.22919
Publikováno v:
Current Protocols in Cytometry
The poisoning of Topoisomerase II (Top2) has been found to be useful as a therapeutic strategy for the treatment of several tumors. The mechanisms of these agents involves a drug-mediated stabilization of a Top2-DNA complex, termed Top2 cleavage comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1918c01c8d865d490f3d9e9ee498a18a
https://pubmed.ncbi.nlm.nih.gov/28678420
https://pubmed.ncbi.nlm.nih.gov/28678420
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 89(9)
Topoisomerase II (Top2) is an important target for anticancer therapy. A variety of drugs that poison Top2, including several epipodophyllotoxins, anthracyclines, and anthracenediones, are widely used in the clinic for both hematologic and solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d12453bf47bbdfc5bfda7a237f40107
https://pubmed.ncbi.nlm.nih.gov/27517472
https://pubmed.ncbi.nlm.nih.gov/27517472
Etoposide (ETO), a drug used for the treatment of human tumors, is associated with the development of secondary malignancies. Recently, therapeutic strategies have incorporated chemosensitizing agents to improve the tumoral response to this drug. ETO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157686f759b1bf9022ae693bb2553e76
https://link.springer.com/article/10.1007/s10577-015-9478-4
https://link.springer.com/article/10.1007/s10577-015-9478-4
Autor:
Marcelo de Campos Nebel, Gustavo Verón, Miguel Angel Borda, Micaela Palmitelli, Marcela González-Cid
Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a DNA repair enzyme that removes irreversible protein-linked 3′ DNA complexes, 3′ phosphoglycolates, alkylation damage-induced DNA breaks, and 3′ deoxyribose nucleosides. In addition to its extended spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b2c2d83c6d96d23eb25316ebaee867
http://www.sciencedirect.com/science/article/pii/S0027510715300427
http://www.sciencedirect.com/science/article/pii/S0027510715300427