Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Marcelo R. Vargas"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Astrocytes play a key role in the progression of amyotrophic lateral sclerosis (ALS) by actively inducing the degeneration of motor neurons. Motor neurons isolated from receptor for advanced glycation end products (RAGE)‐knockout mice are
Externí odkaz:
https://doaj.org/article/331ce381671742bab024ee5cf4b6a8e2
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 543-551 (2011)
Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive loss of motor neurons. To investigate the role of antioxidant defenses in ALS we us
Externí odkaz:
https://doaj.org/article/0c749cf97a3548e3b3a4d64d2cf06037
Autor:
Ana G. Barbeito, Laura Martinez-Palma, Marcelo R. Vargas, Mariana Pehar, Nelly Mañay, Joseph S. Beckman, Luis Barbeito, Patricia Cassina
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 3, Pp 574-580 (2010)
Exposure to environmental lead (Pb) is a mild risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive degeneration of motor neurons. However, recent evidence has paradoxically linked higher Pb levels in A
Externí odkaz:
https://doaj.org/article/7c3b75ee91c447a4b5831a240afbce3c
Autor:
Marcelo R. Vargas, Neal C. Burton, Li Gan, Delinda A. Johnson, Matthias Schäfer, Sabine Werner, Jeffrey A. Johnson
Publikováno v:
PLoS ONE, Vol 8, Iss 4 (2013)
Externí odkaz:
https://doaj.org/article/5f5b996389e144b68240c92185d77054
Publikováno v:
FASEB J
Nuclear receptor subfamily 1 group D member 1 (NR1D1, also known as Rev-erbα) is a nuclear transcription factor that is part of the molecular clock encoding circadian rhythms and may link daily rhythms with metabolism and inflammation. NR1D1, unlike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbe754486b68472c3f4ab811032b7f2
https://europepmc.org/articles/PMC9223394/
https://europepmc.org/articles/PMC9223394/
Publikováno v:
Glia
Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy homeostasis and inflammation. They participate in fatty acid metabolism by regulating their uptake, transport and availability of ligands to nuclear receptors. In the
Publikováno v:
FASEB J
Most physiological processes in mammals are subjected to daily oscillations that are governed by a circadian system. The circadian rhythm orchestrates metabolic pathways in a time-dependent manner and loss of circadian timekeeping has been associated
Autor:
Benjamin A, Harlan, Kelby M, Killoy, Mariana, Pehar, Liping, Liu, Johan, Auwerx, Marcelo R, Vargas
Publikováno v:
Exp Neurol
Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death in co-culture. Enhancing NAD(+) availability, or increasing the expression of the NAD(+)-d
Autor:
Marcelo R. Vargas, Rodrigo Franco
Publikováno v:
Antioxidants & Redox Signaling. 28:1583-1586
Reduction oxidation (redox) reactions are central to life and when altered, they can promote disease progression. In the brain, redox homeostasis is recognized to be involved in all aspects of central nervous system (CNS) development, function, aging
Publikováno v:
Antioxidants & Redox Signaling. 28:1652-1668
Significance: Nicotinamide adenine dinucleotide (NAD(+)) participates in redox reactions and NAD(+)-dependent signaling processes, which involve the cleavage of NAD(+) coupled to posttranslational modifications of proteins or the production of second