Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Marcelo O. Ortells"'
Autor:
Spencer R. Pierce, Allison L. Germann, Sophia Q. Xu, Saumith L. Menon, Marcelo O. Ortells, Hugo R. Arias, Gustav Akk
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 698 (2023)
The positive allosteric modulators (PAMs) of the α7 nicotinic receptor N-(5-Cl-2-hydroxyphenyl)-N′-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and (E)-3-(furan-2-yl)-N-(p-tolyl)-acrylamide (PAM-2) potentiate the α1β2γ2L GABAA receptor throu
Externí odkaz:
https://doaj.org/article/7b45852e7ea54e64b1ae9c0efcc1c93d
Publikováno v:
Molecules, Vol 26, Iss 8, p 2149 (2021)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates depression symptoms. New e
Externí odkaz:
https://doaj.org/article/58d44cf5ed0f46e0a76b6f38883f65cb
Autor:
Hugo R, Arias, Allison L, Germann, Spencer R, Pierce, Seiji, Sakamoto, Marcelo O, Ortells, Itaru, Hamachi, Gustav, Akk
Publikováno v:
British Journal of Pharmacology. 179:5323-5337
Positive allosteric modulators of the α7 nicotinic acetylcholine (nACh) receptor (α7-PAMs) possess promnesic and procognitive properties and have potential in the treatment of cognitive and psychiatric disorders including Alzheimer's disease and sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a70fc83f9c689a5ac96d1fad03bf7f
https://doi.org/10.1111/bph.15948
https://doi.org/10.1111/bph.15948
Autor:
Han-Shen Tae, Gulce Sevdar, Rabha Younis, Hugo R. Arias, Sinan Cavun, Deniz Bagdas, Mine Sibel Gurun, Zulfiye Gul, Marcelo O. Ortells
Publikováno v:
Neurological Research. 43:1056-1068
Clinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91d10aea918594f0b75ce385631f371
https://doi.org/10.1080/01616412.2021.1949684
https://doi.org/10.1080/01616412.2021.1949684
Publikováno v:
Journal of Natural Products. 82:1953-1960
The alkaloids aristoteline (1), aristoquinoline (2), and aristone (3) were purified from the leaves of the Maqui tree Aristotelia chilensis and chemically characterized by NMR spectroscopy. The pharmacological activity of these natural compounds was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0b36ca1caca07bac25b4e17e5ef5e34
https://doi.org/10.1021/acs.jnatprod.9b00314
https://doi.org/10.1021/acs.jnatprod.9b00314
Publikováno v:
Molecules
Molecules, Vol 26, Iss 2149, p 2149 (2021)
Molecules, Vol 26, Iss 2149, p 2149 (2021)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates depression symptoms. New e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4239d75ecbe250c33a2f86d9d32ae295
http://europepmc.org/articles/PMC8068400
http://europepmc.org/articles/PMC8068400
Autor:
Sofía Gallino, Dominik Feuerbach, Marcelo O. Ortells, Elizabeth Vázquez-Gómez, Jesús García-Colunga, Hugo R. Arias, Andy Hernández-Abrego, Ana Belén Elgoyhen
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 100:1-10
The activity of tricyclic antidepressants (TCAs) at α7 and α9α10 nicotinic acetylcholine receptors (AChRs) as well as at hippocampal α7-containing (i.e., α7*) AChRs is determined by using Ca 2+ influx and electrophysiological recordings. To dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb25cde14ad8ebc440ce3d3cb458fd0
https://doi.org/10.1016/j.biocel.2018.04.017
https://doi.org/10.1016/j.biocel.2018.04.017
Autor:
Marcelo O. Ortells, Can Peng, Sofía Gallino, Xiao Tao Jin, Ryan M. Drenan, Dominik Feuerbach, Jesús García-Colunga, Ana Belén Elgoyhen, Hugo R Arias
Publikováno v:
Neurochem Int
The inhibitory activity of (±)-citalopram on human (h) α3β4, α4β2, and α7 nicotinic acetylcholine receptors(AChRs) was determined by Ca2+ influx assays, whereas its effect on rat α9α10 and mouse habenular α3β4*AChRs by electrophysiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b360102c3c860700ce901dd112e924a9
https://linkinghub.elsevier.com/retrieve/pii/S0197018619303651
https://linkinghub.elsevier.com/retrieve/pii/S0197018619303651
Publikováno v:
Journal of natural products. 82(7)
The alkaloids aristoteline (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ab6661cfefeb3cc9f8c7e85a68db923
https://pubmed.ncbi.nlm.nih.gov/31276409
https://pubmed.ncbi.nlm.nih.gov/31276409
Autor:
Hugo R. Arias, Marcelo O. Ortells
Publikováno v:
Journal of Pediatric Biochemistry. :075-089
Nicotine is the main psychoactive substance present in tobacco, targeting neuronal nicotinic acetylcholine receptors (AChRs). The main effects of nicotine associated with smoking are AChR activation, desensitization, and upregulation, with the subseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea451f068453967af9324d7d70ce54e6
https://doi.org/10.1055/s-0036-1586370
https://doi.org/10.1055/s-0036-1586370