An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT-Bleed study

Autor: Hanny Al-Samkari, Raj S. Kasthuri, Joseph G. Parambil, Hasan A. Albitar, Yahya A. Almodallal, Carolina Vázquez, Marcelo M. Serra, Sophie Dupuis-Girod, Craig B. Wilsen, Justin P. McWilliams, Evan H. Fountain, James R. Gossage, Clifford R. Weiss, Muhammad A. Latif, Assaf Issachar, Meir Mei-Zahav, Mary E. Meek, Miles Conrad, Josanna Rodriguez-Lopez, David J. Kuter, Vivek N. Iyer

Publikováno v: Haematologica, Vol 106, Iss 8 (2020)

Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu disease) is a rare multisystem vascular disorder causing chronic gastrointestinal bleeding, epistaxis, and severe anemia. Bevacizumab, an anti-vascular endothelial growth factor antibody,

Externí odkaz: https://doaj.org/article/5212c2e98ac741cb90e807f30327a909

Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia

Autor: Justin P. McWilliams, Miles Conrad, Mary Porteous, Mary E. Meek, James R. Gossage, Jay F. Piccirillo, Masaki Komiyama, Elisabetta Buscarini, Carlo Sabbà, Andrea Lausman, Paul J. Rochon, Ketil Heimdal, Rose Pantalone, Claire L. Shovlin, Valerie A. Palda, Hanny Al-Samkari, Kevin Korenblatt, Marianne S. Clancy, Jamie McDonald, Katharine J. Henderson, Marie E. Faughnan, Claudia Crocione, Steven W. Hetts, Erik Deslandres, Urban W. Geisthoff, Ingrid Winship, Els de Gussem, Vivek N. Iyer, Daniel Cortes, Sophie Dupuis-Girod, Beth Plahn, Kelly Lang-Robertson, Patrick Foy, Mark S. Chesnutt, Ivan Radovanovic, Anette Drøhse Kjeldsen, Felix Ratjen, Johannes J. Mager, Carol Derksen, Adrienne M. Hammill, Sara Palmer, Marcelo M. Serra, Jack McMahon, Josanna Rodriguez-Lopez, Andrew J. White, Roberto Zarrabeitia, Raj S. Kasthuri, Marco C. Post, Jama M. Darling, Scott E. Olitsky, Dennis L. Sprecher, Murali M. Chakinala, Kevin J. Whitehead, David M. Poetker, Meir Mei-Zahav

Publikováno v: Faughnan, M E, Mager, J J, Hetts, S W, Palda, V A, Lang-Robertson, K, Buscarini, E, Deslandres, E, Kasthuri, R S, Lausman, A, Poetker, D, Ratjen, F, Chesnutt, M S, Clancy, M, Whitehead, K J, Al-Samkari, H, Chakinala, M, Conrad, M, Cortes, D, Crocione, C, Darling, J, de Gussem, E, Derksen, C, Dupuis-Girod, S, Foy, P, Geisthoff, U, Gossage, J R, Hammill, A, Heimdal, K, Henderson, K, Iyer, V N, Kjeldsen, A D, Komiyama, M, Korenblatt, K, McDonald, J, McMahon, J, McWilliams, J, Meek, M E, Mei-Zahav, M, Olitsky, S, Palmer, S, Pantalone, R, Piccirillo, J F, Plahn, B, Porteous, M E M, Post, M C, Radovanovic, I, Rochon, P J, Rodriguez-Lopez, J, Sabba, C, Serra, M, Shovlin, C, Sprecher, D, White, A J, Winship, I & Zarrabeitia, R 2020, ' Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia ', Annals of Internal Medicine, vol. 173, no. 12, pp. 989-1001 . https://doi.org/10.7326/M20-1443

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease with an estimated prevalence of 1 in 5000 that is characterized by the presence of vascular malformations (VMs). These result in chronic bleeding, acute hemorrhage, and comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ee4994475518c545cc94de43b382bf
https://doi.org/10.7326/m20-1443

SARS-CoV-2 diagnostic diary: from rumors to the first case. Early reports of molecular tests from the military research and diagnostic institute of Rio de Janeiro

Autor: Marcos Dornelas-Ribeiro, Marcio da Costa Cipitelli, Elaine Cristina Amaro de Melo, Rebeca Araujo da Silva, Marcelo M Serra, Nadia Vaez Gonçalves da Cruz, Tatiana Ls Nogueira, André L Meriano, Alberto Ml Colares, Caleb G M Santos, Elizabeth Valentin

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 115 (2020)
Memórias do Instituto Oswaldo Cruz, Volume: 115, Article number: e200200, Published: 13 JUL 2020
Memórias do Instituto Oswaldo Cruz

Corona virus disease (COVID-19) presents a serious threat to global health. A historical timeline of early molecular diagnostics from government alert (January 22) (D) was presented. After in silico analysis, Brazilian Army Institute of Biology (IBEx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afeb83d2a94637265fbd3aead08ca484
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762020000100410&tlng=en

Bevacizumab for treating Hereditary Hemorrhagic Telangiectasia patients with severe hepatic involvement or refractory anemia

Autor: Augusto Ferraris, J. C. Bandi, Marcelo M. Serra, María Laura Gonzalez, Carolina Vázquez

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 2, p e0228486 (2020)

Objective To report our clinical experience with bevacizumab in a cohort of Hereditary Hemorrhagic Telangiectasia (HHT) patients with severe hepatic involvement and/or refractory anemia. Methods Observational, ambispective study of the Institutional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6edfab50250e31de961f0eb5e8869c
http://europepmc.org/articles/PMC7006931

Central nervous system manganese induced lesions and clinical consequences in patients with hereditary hemorrhagic telangiectasia

Autor: Marcelo M. Serra, Diego Giunta, J. C. Bandi, C. V. Stefani, C. H. Besada, Cristina Elizondo, Angel Golimstok, Diego Javierq Bauso, A. Saenz, A. Cabana Cal

Publikováno v: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-10 (2017)

Background Around 47–74% of patients with hereditary hemorrhagic telangiectasia (HHT) have hepatic vascular malformations (HVMs); magnetic resonance images (MRI) of the central nervous system (CNS) might show in T1 sequences a hyper-intensity signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7289adaec98c607543dc4f4dcf5b9d