Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Marcelo M. Morales"'
Autor:
Luisa H. A. Silva, Mariana C. Silva, Juliana B. Vieira, Emilia C. D. Lima, Renata C. Silva, Daniel J. Weiss, Marcelo M. Morales, Fernanda F. Cruz, Patricia R. M. Rocco
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 10, Pp 1244-1256 (2020)
Abstract Silicosis is a pneumoconiosis caused by inhaled crystalline silica microparticles, which trigger inflammatory responses and granuloma formation in pulmonary parenchyma, thus affecting lung function. Although systemic administration of mesenc
Externí odkaz:
https://doaj.org/article/7c4f907b737341bdb88e48d50501fb0b
Autor:
José Monteiro Sad Pereira, André Luis Barreira, Conrado Rodrigues Gomes, Felipe Mateus Ornellas, Débora Santos Ornellas, Luiz Carlos Miranda, Lucio Ronaldo Cardoso, Robson Coutinho-Silva, Alberto Schanaider, Marcelo M. Morales, Maurilo Leite, Christina Maeda Takiya
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Previous study showed that purinergic P2X7 receptors (P2X7R) reach the highest expression in the first week after unilateral ureteral obstruction (UUO) in mice, and are involved in the process of inflammation, apoptosis and fibros
Externí odkaz:
https://doaj.org/article/ac760e3d1bb141338de43c033726baf6
Autor:
Fabio S. Aguiar, André S. Melo, Ana Maria S. Araújo, Alexandre P. Cardoso, Sergio Augusto L. de Souza, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Debora G. Xisto, Karina D. Asensi, Lanuza Faccioli, Anna Beatriz S. Salgado, Maria Carolina P. P. Landesmann, Regina C. S. Goldenberg, Bianca Gutfilen, Marcelo M. Morales, Patricia R. M. Rocco, Jose R. Lapa e Silva
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2020)
Abstract Background Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and long-acting β2-adrenoce
Externí odkaz:
https://doaj.org/article/625d3159a0524f6e83bf88b351fd567d
Autor:
Ligia L. Castro, Jamil Z. Kitoko, Debora G. Xisto, Priscilla C. Olsen, Herbert L. M. Guedes, Marcelo M. Morales, Miquéias Lopes‐Pacheco, Fernanda F. Cruz, Patricia R. M. Rocco
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 2, Pp 250-260 (2020)
Abstract In experimental house dust mite (HDM)‐induced allergic asthma, therapeutic administration of a single dose of adipose tissue‐derived mesenchymal stromal cells (MSCs) ameliorates lung inflammation but is unable to reverse remodeling. We h
Externí odkaz:
https://doaj.org/article/c79e6666c58b4b26868e0c47c4f37a66
Autor:
Johnatas D. Silva, Miquéias Lopes-Pacheco, Ligia L. de Castro, Jamil Z. Kitoko, Stefano A. Trivelin, Natália R. Amorim, Vera L. Capelozzi, Marcelo M. Morales, Bianca Gutfilen, Sergio A. L. de Souza, Daniel J. Weiss, Bruno L. Diaz, Patricia R. M. Rocco
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2019)
Abstract Background Even though mesenchymal stromal cells (MSCs) mitigate lung and distal organ damage in experimental polymicrobial sepsis, mortality remains high. We investigated whether preconditioning with eicosapentaenoic acid (EPA) would potent
Externí odkaz:
https://doaj.org/article/62292f89b5ca4343b769d7aa0af9d64c
Autor:
Hananda A. Poggio, Mariana A. Antunes, Nazareth N. Rocha, Jamil Z. Kitoko, Marcelo M. Morales, Priscilla C. Olsen, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Patricia R. M. Rocco
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract Background A single administration of mesenchymal stromal cells (MSCs) has been shown to reduce lung inflammation in experimental elastase-induced emphysema; however, effects were limited in terms of lung-tissue repair and cardiac function i
Externí odkaz:
https://doaj.org/article/2abaab8a77004bdd8202c232f6989419
Autor:
Lígia de A. Maia, Marcos V. S. Fernandes, Raquel S. Santos, Laís C. Agra, Anna Carolinna Carvalho, Nazareth de N. Rocha, Milena V. Oliveira, Cíntia L. Santos, Marcelo M. Morales, Vera L. Capelozzi, Sergio A. L. Souza, Bianca Gutfilen, Marcus J. Schultz, Marcelo Gama de Abreu, Paolo Pelosi, Pedro L. Silva, Patricia R. M. Rocco
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Intraoperative positive end-expiratory pressure (PEEP) has been proposed to restore lung volumes and improve respiratory function in obesity. However, the biological impact of different PEEP levels on the lungs in obesity remains unknown. We aimed to
Externí odkaz:
https://doaj.org/article/3902487fb493446dabb2fdd8a4f9573a
Autor:
Elga Bandeira, Helena Oliveira, Johnatas D. Silva, Rubem F. S. Menna-Barreto, Christina M. Takyia, Jung S. Suk, Kenneth W. Witwer, Michael E. Paulaitis, Justin Hanes, Patricia R. M. Rocco, Marcelo M. Morales
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive lung fibrosis and ultimately causing respiratory failure. Mesenchymal stromal cells (MSCs) have been shown to exert therap
Externí odkaz:
https://doaj.org/article/e0fce8b21f194a74a8f698ed49fe2d80
Autor:
Johnatas D. Silva, Ligia L. de Castro, Cassia L. Braga, Gisele P. Oliveira, Stefano A. Trivelin, Carlos M. Barbosa-Junior, Marcelo M. Morales, Claudia C. dos Santos, Daniel J. Weiss, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Patricia R. M. Rocco
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Although mesenchymal stromal cells (MSCs) have demonstrated beneficial effects on experimental acute respiratory distress syndrome (ARDS), preconditioning may be required to potentiate their therapeutic effects. Additionally, administration of cell-f
Externí odkaz:
https://doaj.org/article/aa66a863b23f49bc9563f5a35afdd5f4
Autor:
Sabrina V. Martini, Adriana L. Silva, Debora Ferreira, Rafael Rabelo, Felipe M. Ornellas, Karina Gomes, Patricia R.M. Rocco, Hilda Petrs-Silva, Marcelo M. Morales
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 2, Pp 544-553 (2016)
Background/Aims: Adeno-associated virus (AAV) vectors are being increasingly used as the vector of choice for in vivo gene delivery and gene therapy for many pulmonary diseases. Recently, it was shown that phosphorylation of surface-exposed tyrosine
Externí odkaz:
https://doaj.org/article/236f387813df470e89a874b843b99674