Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Marcelo Jacobs-Lorena"'
Autor:
Marcelo Jacobs-Lorena, Sung-Jae Cha
Publikováno v:
Emerging Microbes and Infections (2024)
Malaria is among the deadliest infectious diseases. Over 200 million annual clinical malaria cases are reported and more than half a million people, mostly children, die every year. The most advanced RTS,S/AS01 vaccine based on the P. falciparum circ
Externí odkaz:
https://doaj.org/article/e30304767ca24b1eb265a1f99fc7412a
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionLeishmaniasis comprises a complex group of diseases caused by protozoan parasites from the Leishmania genus, presenting a significant threat to human health. Infection starts by the release into the skin of metacyclic promastigote (MP) fo
Externí odkaz:
https://doaj.org/article/78acb6cea7c8431aa3719f91dcfa4eb7
Autor:
Sung-Jae Cha, Joel Vega-Rodriguez, Dingyin Tao, Heather M. Kudyba, Kelly Hanner, Marcelo Jacobs-Lorena
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Plasmodium fertilization, an essential step for the development of the malaria parasite in the mosquito, is a prime target for blocking pathogen transmission. Using phage peptide display screening, we identified MG1, a peptide that binds to
Externí odkaz:
https://doaj.org/article/db04b044c8dc4d22bde02b008c644950
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
After transmission of Plasmodium sporozoites from infected mosquitoes, parasites first infect hepatocytes. Here, Cha et al. identify a sporozoite ligand (phospholipid scramblase) and the hepatocytic receptor (carbamoyl-phosphate synthetase 1) as rele
Externí odkaz:
https://doaj.org/article/d8ed248f9c5e47a38f04d306b2a1b9da
Publikováno v:
eLife, Vol 11 (2022)
Malaria is among the deadliest infectious diseases, and Plasmodium, the causative agent, needs to complete a complex development cycle in its vector mosquito for transmission to occur. Two promising strategies to curb transmission are transgenesis, c
Externí odkaz:
https://doaj.org/article/fcda4b9d09394aa9bc8dc61348f201ce
Autor:
Timothy James Russell, Erandi K De Silva, Valerie M Crowley, Kathryn Shaw-Saliba, Namita Dube, Gabrielle Josling, Charisse Flerida A Pasaje, Irene Kouskoumvekaki, Gianni Panagiotou, Jacquin C Niles, Marcelo Jacobs-Lorena, C Denise Okafor, Francisco-Javier Gamo, Manuel Llinás
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010887 (2022)
Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial dru
Externí odkaz:
https://doaj.org/article/32dbbe0804b44aea83886f60da9addc8
Autor:
Jéssica I. de Paula, Eduardo J. Lopes-Torres, Marcelo Jacobs-Lorena, Marcia Cristina Paes, Sung-Jae Cha
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
BackgroundChagas is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. On the order of seven million people are infected worldwide and current therapies are limited, highlighting the urgent need for new interventions. T.
Externí odkaz:
https://doaj.org/article/088f19629e7a45f5ae33320dbf86cd5a
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020)
Abstract Background A previous study reported that the malaria parasite Plasmodium falciparum enters an altered growth state upon extracellular withdrawal of the essential amino acid isoleucine. Parasites slowed transit through the cell cycle when de
Externí odkaz:
https://doaj.org/article/d8f539c67172491798e68f02d0055c3b
Autor:
Tales Vicari Pascini, Marcelo Ramalho-Ortigão, José Marcos Ribeiro, Marcelo Jacobs-Lorena, Gustavo Ferreira Martins
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background Successful mating of female mosquitoes typically occurs once, with the male sperm being stored in the female spermatheca for every subsequent oviposition event. The female spermatheca is responsible for the maintenance, nourishmen
Externí odkaz:
https://doaj.org/article/4bb5838808ae481aafd5237f3c898910
Autor:
Sung-Jae Cha, Xiang Yu, Brian D. Gregory, Yong Seok Lee, Tomoko Ishino, Robert O. Opoka, Chandy C. John, Marcelo Jacobs-Lorena
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Cerebral malaria (CM), coma caused by Plasmodium falciparum-infected red blood cells (iRBCs), is the deadliest complication of malaria. The mechanisms that lead to CM development are incompletely understood. Here we report on the identificat
Externí odkaz:
https://doaj.org/article/55981d5b5a3d405c8e8c14cc1be98e6b