Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Marcelo G. Roma"'
Publikováno v:
Annals of Hepatology, Vol 7, Iss 1, Pp 16-33 (2008)
Oxidative stress is a common feature in most hepatopathies. In recent years, evidence has accumulated that reactive oxygen species (ROS) induce a number of functional changes either deleterious or adaptive in the capability of the hepatocytes to prod
Externí odkaz:
https://doaj.org/article/3d70f960930443f6a43a9e07c6399078
Publikováno v:
Antioxidants & Redox Signaling. 35:808-831
Significance: Most hepatopathies are primarily or secondarily cholestatic in nature. Oxidative stress (OS) is a frequent trait among them, and impairs the machinery to generate bile by triggering e...
Publikováno v:
Seminars in liver disease. 41(3)
Publikováno v:
Seminars in liver disease. 41(3)
The most concerned issue in the context of drug/herb-induced chronic cholestasis is vanishing bile duct syndrome. The progressive destruction of intrahepatic bile ducts leading to ductopenia is usually not dose dependent, and has a delayed onset that
Autor:
Gisel Sabrina Miszczuk, Virginia Soledad Schuck, Fernando A. Crocenzi, Enrique J. Sánchez Pozzi, Nadia Ciriaci, Anabela Carolina Medeot, Romina Belén Andermatten, María Laura Ruiz, Ismael Ricardo Barosso, Marcelo G. Roma, María Valeria Razori
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
TNFα is a cytokine whose levels are increased in inflammatory pathologies that are associated with cholestasis. Endocytic internalization of Abcc2 (multidrug resistance-associated protein 2), a canalicular transporter of organic anions that is impli
Autor:
Marcelo G. Roma, Arturo Simoni-Nieves, Soraya Salas-Silva, Jocelyn Lopez-Ramirez, Leticia Bucio, María Concepción Gutiérrez-Ruiz, Luis Enrique Gómez-Quiroz
Publikováno v:
Life Sciences. 218:324-339
Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopath
Autor:
Soraya Salas-Silva, Jocelyn López-Ramirez, Jonatan Barrera-Chimal, Roberto Lazzarini-Lechuga, Arturo Simoni-Nieves, Verónica Souza, Roxana U. Miranda-Labra, Felipe Masso, Marcelo G. Roma, María Concepción Gutiérrez-Ruiz, Leticia Bucio-Ortiz, Luis E. Gomez-Quiroz
Publikováno v:
Life Sciences. 295:120423
Hepatocyte growth factor (HGF) has been proved to protect the liver against α-naphthylisothiocyanate (ANIT)-induced cholestasis by acting as an antioxidant agent and redirecting toxic biliary solutes towards blood for urinary excretion. However, thi
Autor:
Romina Belén Andermatten, María Laura Ruiz, Cecilia Lorena Basiglio, Paula María Maidagan, Nadia Ciriaci, Enrique J. Sánchez Pozzi, Ismael Ricardo Barosso, María Valeria Razori, Marcelo G. Roma, Pamela Lucía Martín
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Aims: Lipopolysaccharide (LPS) induces inflammatory cholestasis by impairing expression, localization, and function of carriers involved in bile formation, e.g. bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2). A spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8865b4c1d6be3c72ed1c39a0f84a57a1
https://linkinghub.elsevier.com/retrieve/pii/S002432052031105X
https://linkinghub.elsevier.com/retrieve/pii/S002432052031105X
Autor:
Ismael R Barosso, Andrés E Zucchetti, Andrea C Boaglio, M Cecilia Larocca, Diego R Taborda, Marcelo G Luquita, Marcelo G Roma, Fernando A Crocenzi, Enrique J Sánchez Pozzi
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50711 (2012)
UnlabelledEstradiol 17ß-D-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kina
Externí odkaz:
https://doaj.org/article/84c3f8f9c4aa4c06b43872c5efbda6ac
Autor:
Andrea C Boaglio, Andrés E Zucchetti, Flavia D Toledo, Ismael R Barosso, Enrique J Sánchez Pozzi, Fernando A Crocenzi, Marcelo G Roma
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49255 (2012)
The endogenous, cholestatic metabolite estradiol 17ß-D-glucuronide (E(2)17G) induces endocytic internalization of the canalicular transporters relevant to bile formation, Bsep and Mrp2. We evaluated here whether MAPKs are involved in this effect.ERK
Externí odkaz:
https://doaj.org/article/ff8c5f56b4ca4eb1b37e5813297fe616