Výsledky vyhledávání - "Marcelo Fiori Marchiori"

SARS-CoV2 e Covid-19: aspectos fisiopatológicos e imunológicos, estratégias de diagnóstico e desenvolvimento de vacinas

Autor: Catarina Bárbara Chiocca do Nascimento, Marcelo Fiori Marchiori, Vanessa Leiria Campo, Monica Magalhães Costa Zini

Publikováno v: Revista Interdisciplinar de Saúde e Educação. 1:122-158

O vírus SARS-CoV-2, de provável origem morcegal, foi inicialmente detectado na China e é o agente etiológico da doença denominada COVID-19. Em 11 de março de 2020 a Organização Mundial de Saúde (OMS) declarou a pandemia. A emergência do ví

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52c25479538c6e9da7890c399ac95f42
https://doi.org/10.56344/2675-4827.v1n2a20208

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Neuroprotective Effects of Cholinesterase Inhibitors: Current Scenario in Therapies for Alzheimer's Disease and Future Perspectives

Autor: Natália Chermont dos Santos Moreira, Jéssica Ellen Barbosa de Freitas Lima, Marcelo Fiori Marchiori, Ivone Carvalho, Elza Tiemi Sakamoto-Hojo

Publikováno v: Journal of Alzheimer's disease reports. 6(1)

Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disease conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to the mild, moderate, and severe clinical stages of AD dementia. AD is considered a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fabab05156e359c1ac0410baf867b0f
https://pubmed.ncbi.nlm.nih.gov/35591949

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Multifaceted antibodies development against synthetic α-dystroglycan mucin glycopeptide as promising tools for dystroglycanopathies diagnostic

Autor: Thais Canassa-DeLeo, Marcelo Fiori Marchiori, Vanessa Leiria Campo, Lilian Cataldi Rodrigues, Andrea Queiroz Maranhão, Marcelo M. Brigido, Annamaria Sandomenico, Menotti Ruvo, Marcelo Dias-Baruffi, Carlos Alessandro Fuzo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Dystroglycanopathies are diseases characterized by progressive muscular degeneration and impairment of patient's quality of life. They are associated with altered glycosylation of the dystrophin-glycoprotein (DGC) complex components, such as α-dystr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f05f35151ffdda53143a857ffba1eab
https://doi.org/10.1007/s10719-019-09893-z

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Synthesis of MUC1-derived glycopeptide bearing a novel triazole STn analog

Autor: Leandro Oliveira Bortot, Vanessa Leiria Campo, Marcelo Fiori Marchiori, Ivone Carvalho

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The synthesis of MUC1 glycopeptides bearing modified tumor-associated carbohydrate antigens (TACAs) represents an effective strategy to develop potential antitumor vaccines that trigger strong immune response. In this context, we present herein the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02611998e09bf8ef8b78b45b6648e63
https://pubmed.ncbi.nlm.nih.gov/33010570

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Insights into Anti-Trypanosomal Agents Based on Synthetic Glycoconjugates

Autor: Vanessa Leiria Campo, Ivone Carvalho, Marcelo Fiori Marchiori

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Chagas disease is still a worldwide threat, with estimated 6 to 7 million infected people, mainly in Latin America. Current treatments still rely only on benznidazol and nifurtimox, drugs with poor efficacy in chronic infection phase and recognized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9965ef6aa909ca632678d6bdb05d001d
https://doi.org/10.2174/1568026618666180509145305

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Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion

Autor: Marcelo Fiori Marchiori, Giuseppina Focà, Marcelo Dias-Baruffi, Nunzianna Doti, Menotti Ruvo, Leandro Oliveira Bortot, Ivone Carvalho, Getúlio G. Junqueira, Peterson de Andrade, Vanessa Leiria Campo, Thalita B. Riul

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The synthesis of the O-3 triazole-linked galactosyl arylsulfonamides 1–7 as potential inhibitors of Trypanosoma cruzi cell invasion is described. These target compounds were synthesized by Cu(I)-catalysed azide-alkyne cycloaddition reaction (‘cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cbbf40c7c3693c93c21b3974c64bf4
https://doi.org/10.1016/j.bmc.2017.09.042

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Síntese de glicopeptídeo de mucina, contendo análogo de antígeno tumoral, com possíveis aplicações terapêuticas em câncer

Autor: Marcelo Fiori Marchiori

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

As mucinas são glicoproteínas de alto peso molecular, que tem como característica fundamental a ligação entre o açúcar ?GalNAc e resíduos de aminoácidos de Ser/Thr (?GalNAc-Ser/Thr). Em tumores, a biossíntese de mucinas encontra-se desregul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de8759369e4ba540bb9dab6d26f7dcc
https://doi.org/10.11606/d.60.2020.tde-23052019-091042

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Galactosyl and sialyl clusters: synthesis and evaluation against T. cruzi parasite

Autor: Thais Canassa De Leo, Anna Karoline A. Fleuri, Thalita B. Riul, Sergio Schenkman, Peterson de Andrade, Marcelo Dias Baruffi, Ivone Carvalho, Andreza S. Figueredo, Marcelo Fiori Marchiori

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The multivalent effect of carbohydrates (glycoclusters) has been explored to study important biological targets and processes involving Trypanosoma cruzi (T. cruzi) infection. Likewise, CuAAC cycloaddition reactions (click chemistry) have been applie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c113d164c2e4d888b6e0ada89385a567

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Synthesis of novel triazole-derived glycopeptides as analogs of α-dystroglycan mucins

Autor: Marcelo Fiori Marchiori, Marcelo Dias-Baruffi, Vanessa Leiria Campo, Giulia Pompolo Iossi, Leandro Oliveira Bortot

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

α-Dystroglycan (α-DG) mucins are essential for maintenance of the structural and functional stability of the muscle fiber and, when hypoglycosylated, they are directly involved in pathological processes such as dystroglycanopathies. Thus, this work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcee5a268bec25cc5b6a12678247919b
https://pubmed.ncbi.nlm.nih.gov/30453095

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Synthetic 1,2,3-triazole-linked glycoconjugates bind with high affinity to human galectin-3

Autor: João Francisco Pereira, Vanessa Leiria Campo, Marcelo Fiori Marchiori, Richard D. Cummings, Lauro T. Kubota, Dênio Emanuel Pires Souto, Ivone Carvalho, Leandro Oliveira Bortot, Marcelo Dias-Baruffi

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

This work describes the synthesis of the 1,2,3-triazole amino acid-derived-3-O-galactosides 1-6 and the 1,2,3-triazole di-lactose-derived glycoconjugate 7 as potential galectin-3 inhibitors. The target compounds were synthesized by Cu(I)-catalyzed az

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e8e09e54aab8f8ebff7dcc6a6759d8
https://doi.org/10.1016/j.bmc.2015.04.044

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