Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Marcelo Farina"'
Autor:
Jian Chen, Zehua Tao, Xinyu Zhang, Jing Hu, Suhua Wang, Guangwei Xing, Ngwa Adeline Ngeng, Abdul Malik, Kwaku Appiah-Kubi, Marcelo Farina, Anatoly V. Skalny, Alexey Tinkov, Michael Aschner, Bobo Yang, Rongzhu Lu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 279, Iss , Pp 116481- (2024)
Manganese (Mn) overexposure has been associated with the development of neurological damage reminiscent of Parkinson's disease, while the underlying mechanisms have yet to be fully characterized. This study aimed to investigate the mechanisms leading
Externí odkaz:
https://doaj.org/article/409829aeb3b44f938f2e91a03ab672a7
Autor:
Hengrui Liu, Sho Iketani, Arie Zask, Nisha Khanizeman, Eva Bednarova, Farhad Forouhar, Brandon Fowler, Seo Jung Hong, Hiroshi Mohri, Manoj S. Nair, Yaoxing Huang, Nicholas E. S. Tay, Sumin Lee, Charles Karan, Samuel J. Resnick, Colette Quinn, Wenjing Li, Henry Shion, Xin Xia, Jacob D. Daniels, Michelle Bartolo-Cruz, Marcelo Farina, Presha Rajbhandari, Christopher Jurtschenko, Matthew A. Lauber, Thomas McDonald, Michael E. Stokes, Brett L. Hurst, Tomislav Rovis, Alejandro Chavez, David D. Ho, Brent R. Stockwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Small molecule drugs promise to remain a valuable tool in controlling the ongoing COVID-19 pandemic. Here the authors describe optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for potential treatment of COVID-19.
Externí odkaz:
https://doaj.org/article/ca1887901eef4f3082b30b23a613d463
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2910 (2023)
Neuron-glia interactions are essential for the central nervous system’s homeostasis. Microglial cells are one of the key support cells in the brain that respond to disruptions in such homeostasis. Although their participation in neuroinflammation i
Externí odkaz:
https://doaj.org/article/67bde1108e984580bddff0cf7a1378e1
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2043 (2022)
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a redox-sensitive transcription factor that binds to the antioxidant response element consensus sequence, decreasing reactive oxygen species and regulating the transcription of a wide array of gen
Externí odkaz:
https://doaj.org/article/90c7f1932abc4480b9e8a61a20401dc6
Autor:
Ruth Liliám Quispe, Michael Lorenz Jaramillo, Leticia Selinger Galant, Daiane Engel, Alcir Luiz Dafre, João Batista Teixeira da Rocha, Rafael Radi, Marcelo Farina, Andreza Fabro de Bem
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 118-129 (2019)
Oxidative stress and mitochondrial dysfunction are critical events in neurodegenerative diseases; therefore, molecules that increase cellular antioxidant defenses represent a future pharmacologic strategy to counteract such conditions. The aim of thi
Externí odkaz:
https://doaj.org/article/25b0b235060a419990795b7ba5e65efd
Autor:
Cristine de Paula Nascimento-Castro, Elisa C. Winkelmann-Duarte, Gianni Mancini, Priscilla Gomes Welter, Evelini Plácido, Marcelo Farina, Joana Gil-Mohapel, Ana Lúcia S. Rodrigues, Andreza Fabro de Bem, Patricia S. Brocardo
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1433 (2022)
Huntington’s disease (HD) is a genetic neurodegenerative disease characterized by motor, psychiatric, and cognitive symptoms. Emerging evidence suggests that emotional and cognitive deficits seen in HD may be related to hippocampal dysfunction. We
Externí odkaz:
https://doaj.org/article/f76cc44072f5426a9693e92fe72a028b
Publikováno v:
Molecules, Vol 26, Iss 16, p 5001 (2021)
Ischemic stroke, characterized by the sudden loss of blood flow in specific area(s) of the brain, is the leading cause of permanent disability and is among the leading causes of death worldwide. The only approved pharmacological treatment for acute i
Externí odkaz:
https://doaj.org/article/d36cf38497c744b2b6262dbf73b7fa93
Publikováno v:
Colloquium Humanarum, Vol 13, Iss 3, Pp 70-75 (2016)
This study uses the deductive method, dialectical and empirical for through doctrinal, jurisprudential and legal research to contribute to the analysis of contractarian theories, their historical context and application period. With the liberal rev
Externí odkaz:
https://doaj.org/article/22d25d8fe4a84705bcbfd8236372fc9f
Autor:
Takamitsu Unoki, Masahiro Akiyama, Yoshito Kumagai, Filipe Marques Gonçalves, Marcelo Farina, João Batista Teixeira da Rocha, Michael Aschner
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Methylmercury (MeHg) is a potent neurotoxin that affects particularly the developing brain. Since MeHg is a potent electrophilic agent, a wide range of intracellular effects occur in response to its exposure. Yet, the molecular mechanisms associated
Externí odkaz:
https://doaj.org/article/c0896443ab0a4ad8bf03de8846cffb90
Autor:
Cristine de Paula Nascimento-Castro, Ana Claudia Wink, Victor Silva da Fônseca, Claudia Daniele Bianco, Elisa C. Winkelmann-Duarte, Marcelo Farina, Ana Lúcia S. Rodrigues, Joana Gil-Mohapel, Andreza Fabro de Bem, Patricia S. Brocardo
Publikováno v:
Neural Plasticity, Vol 2018 (2018)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a trinucleotide expansion in the HD gene, resulting in an extended polyglutamine tract in the protein huntingtin. HD is traditionally viewed as a movement disor
Externí odkaz:
https://doaj.org/article/3a66d36f1d274d5b8a89a833eda53d0d