Zobrazeno 1 - 10
of 448
pro vyhledávání: '"Marcelo CYPEL"'
Autor:
Paolo Oliveira-Melo, Natalia Aparecida Nepomuceno, Liliane Moreira Ruiz, Aristides Tadeu Correia, Vanessa Sana Vilela, Karina Andrighetti de Oliveira Braga, Giovana Maria Manzuti, Deymisson Damitene Martins Feitosa, Emanuel Kennedy-Feitosa, Aizhou Wang, Marcelo Cypel, Paulo Manuel Pêgo Fernandes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Brain death (BD) provides most of the donor organs destined for lung transplantation (LTx). However, the organs may be affected by inflammatory and oxidative processes. Based on this, we hypothesize that the angiotensin-converting enzyme 2 (
Externí odkaz:
https://doaj.org/article/6a6ffc43bb4141b2993b52aeba8684f5
Autor:
Bonnie T. Chao, Andrew T. Sage, Micheal C. McInnis, Jun Ma, Micah Grubert Van Iderstine, Xuanzi Zhou, Jerome Valero, Marcelo Cypel, Mingyao Liu, Bo Wang, Shaf Keshavjee
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract Ex vivo lung perfusion (EVLP) enables advanced assessment of human lungs for transplant suitability. We developed a convolutional neural network (CNN)-based approach to analyze the largest cohort of isolated lung radiographs to date. CNNs we
Externí odkaz:
https://doaj.org/article/9b94c9591838494dbf74adbf9d2131d7
Autor:
David F. Bodenstein, Gabriel Siebiger, Yimu Zhao, Aaron J. Clasky, Avinash N. Mukkala, Erika L. Beroncal, Lauren Banh, Lili Aslostovar, Sonya Brijbassi, Sarah E. Hogan, James D. McCully, Mohadeseh Mehrabian, Thomas H. Petersen, Lisa A. Robinson, Melanie Walker, Constantine Zachos, MITO2i-MbD Mitochondrial Transplant Consortium, Sowmya Viswanathan, Frank X. Gu, Ori D. Rotstein, Marcelo Cypel, Milica Radisic, Ana C. Andreazza
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mitochondrial transplantation and transfer are being explored as therapeutic options in acute and chronic diseases to restore cellular function in injured tissues. To limit potential immune responses and rejection of donor mitochondria, curr
Externí odkaz:
https://doaj.org/article/4a13d8c687d747fc9539f5b0cbed7d9b
Autor:
Mailton Prestes Madruga, Lucas Kich Grun, Letícya Simone Melo Dos Santos, Frederico Orlando Friedrich, Douglas Bitencourt Antunes, Marcella Elesbão Fogaça Rocha, Pedro Luis Silva, Gilson P. Dorneles, Paula Coelho Teixeira, Tiago Franco Oliveira, Pedro R.T. Romão, Lucas Santos, José Claudio Fonseca Moreira, Vinicius Schenk Michaelsen, Marcelo Cypel, Marcos Otávio Brum Antunes, Marcus Herbert Jones, Florencia María Barbé-Tuana, Moisés Evandro Bauer
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and paracrine inflammation;
Externí odkaz:
https://doaj.org/article/7b6f501192a54d04a10da4315ec6771d
Publikováno v:
Revista Médica Clínica Las Condes, Vol 35, Iss 1, Pp 39-44 (2024)
Resumen: Uno de los grandes obstáculos que presenta el trasplante de órganos es el tiempo en que se puede preservar el órgano en isquemia en un estado viable antes de ser implantado. Con la utilización de la técnica estándar de conservación es
Externí odkaz:
https://doaj.org/article/65c6d7573f8447b0a0a59b16699fe0a5
Autor:
Kukbin Choi, MD, Cristiano Spadaccio, MD, PhD, Rafaela V.P. Ribeiro, MD, PhD, Blake T. Langlais, MS, Mauricio A. Villavicencio, MD, Kelly Pennington, MD, Philip J. Spencer, MD, Richard C. Daly, MD, Jorge Mallea, MD, Shaf Keshavjee, MD, MSc, Marcelo Cypel, MD, MSc, Sahar A. Saddoughi, MD, PhD
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 1020-1028 (2023)
Objective: Innovative technology such as normothermic regional perfusion and the Organ Care System has expanded donation after circulatory death heart transplantation. We wanted to investigate the impact of donation after circulatory death heart proc
Externí odkaz:
https://doaj.org/article/01216826fcca447d8c559f4412ae0871
Autor:
Nikita Looby, Anna Roszkowska, Miao Yu, German Rios-Gomez, Mauricio Pipkin, Barbara Bojko, Marcelo Cypel, Janusz Pawliszyn
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 10, Pp 1195-1204 (2023)
In vivo lung perfusion (IVLP) is a novel isolated lung technique developed to enable the local, in situ administration of high-dose chemotherapy to treat metastatic lung cancer. Combination therapy using folinic acid (FOL), 5-fluorouracil (F), and ox
Externí odkaz:
https://doaj.org/article/7876020860b34ccbb04d57d29ba516ce
Autor:
Andrew T. Sage, Laura L. Donahoe, Alaa A. Shamandy, S. Hossein Mousavi, Bonnie T. Chao, Xuanzi Zhou, Jerome Valero, Sharaniyaa Balachandran, Aadil Ali, Tereza Martinu, George Tomlinson, Lorenzo Del Sorbo, Jonathan C. Yeung, Mingyao Liu, Marcelo Cypel, Bo Wang, Shaf Keshavjee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract Ex vivo lung perfusion (EVLP) is a data-intensive platform used for the assessment of isolated lungs outside the body for transplantation; however, the integration of artificial intelligence to rapidly interpret the large constellation of cl
Externí odkaz:
https://doaj.org/article/af760de30b88434f8af5439b2c782944
Autor:
Eduard Rodenas-Alesina, Adriana Luk, John Gajasan, Anhar Alhussaini, Genevieve Martel, Cyril Serrick, Karen McRae, Chris Overgaard, Marcelo Cypel, Lianne Singer, Jussi Tikkanen, Shaf Keshavjee, Lorenzo Del Sorbo
Publikováno v:
Transplant International, Vol 37 (2024)
Trends in high-sensitivity cardiac troponin I (hs-cTnI) after lung transplant (LT) and its clinical value are not well stablished. This study aimed to determine kinetics of hs-cTnI after LT, factors impacting hs-cTnI and clinical outcomes. LT recipie
Externí odkaz:
https://doaj.org/article/93a52cfa44724bdeae85a15df2a7fcd4
Autor:
Jonathan Allen, Andrew T. Sage, Haruchika Yamamoto, Gavin W. Wilson, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee, Jonathan C. Yeung
Publikováno v:
JHLT Open, Vol 3, Iss , Pp 100027- (2024)
Donation after cardiac death (DCD) donor lungs have been shown to express less proinflammatory genes than donation after brain death (DBD) lungs, likely due to the absence of brain-death related inflammatory physiology. However, it is unclear whether
Externí odkaz:
https://doaj.org/article/80ce13ec22184a8ebc719d2b3301d5cd