Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Marcelo A Nobrega"'
Autor:
Angela Jane Crean, Alistair McNair Senior, Therese Freire, Thomas Daniel Clark, Flora Mackay, Gracie Austin, Tamara Jayne Pulpitel, Marcelo Aguiar Nobrega, Romain Barrès, Stephen James Simpson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Paternal diet can influence the phenotype of the next generation, yet, the dietary components inducing specific responses in the offspring are not identified. Here, we use the Nutritional Geometry Framework to determine the effects of pre-co
Externí odkaz:
https://doaj.org/article/728550fe9d6d450a99df955ed72345e6
Autor:
Kathryn M. Farris, Alistair M. Senior, Débora R. Sobreira, Robert M. Mitchell, Zachary T. Weber, Lars R. Ingerslev, Romain Barrès, Stephen J. Simpson, Angela J. Crean, Marcelo A. Nobrega
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Diet is a key lifestyle component that influences metabolic health through several factors, including total energy intake and macronutrient composition. While the impact of caloric intake on gene expression and physiological phenomena in var
Externí odkaz:
https://doaj.org/article/7dbebc4349a940b19cdb5cc883a0451e
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36501 (2012)
Genome-wide association studies (GWAS) have repeatedly shown an association between non-coding variants in the TCF7L2 locus and risk for type 2 diabetes (T2D), implicating a role for cis-regulatory variation within this locus in disease etiology. Sup
Externí odkaz:
https://doaj.org/article/b1c777cffab34af896af8128d284aca4
Autor:
Daniel Savic, Margaret G Distler, Greta Sokoloff, Nancy A Shanahan, Stephanie C Dulawa, Abraham A Palmer, Marcelo A Nobrega
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26897 (2011)
The comorbidity of type 2 diabetes (T2D) with several psychiatric diseases is well established. While environmental factors may partially account for these co-occurrences, common genetic susceptibilities could also be implicated in the confluence of
Externí odkaz:
https://doaj.org/article/1e849760520d4d5bb8f40812256f5686
Autor:
Xiao Liu, Ivy Aneas, Noboru Sakabe, Rebecca L. Anderson, Christine Billstrand, Cristina Paz, Harjot Kaur, Brian Furner, Seong Choi, Adriana Y. Prichina, Elizabeth Ann L. Enninga, Haidong Dong, Amy Murtha, Gregory E. Crawford, John A. Kessler, William Grobman, Marcelo A. Nobrega, Sarosh Rana, Carole Ober
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The mechanisms that underlie the timing of labor in humans are largely unknown. In most pregnancies, labor is initiated at term (≥ 37 weeks gestation), but in a signifiicant number of women spontaneous labor occurs preterm and is associate
Externí odkaz:
https://doaj.org/article/36866406c8f749de8cd6bb855b2d226e
Akademický článek
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Autor:
Antoinette F. van Ouwerkerk, Fernanda M. Bosada, Karel van Duijvenboden, Matthew C. Hill, Lindsey E. Montefiori, Koen T. Scholman, Jia Liu, Antoine A. F. de Vries, Bastiaan J. Boukens, Patrick T. Ellinor, Marie José T. H. Goumans, Igor R. Efimov, Marcelo A. Nobrega, Phil Barnett, James F. Martin, Vincent M. Christoffels
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and chromatin conformation datasets, to identify genes associated with atrial fibrillation and fun
Externí odkaz:
https://doaj.org/article/6c47420fc1c646169658c86522780b7c
Autor:
Virginia Chu Cheung, Chian-Yu Peng, Mirna Marinić, Noboru J. Sakabe, Ivy Aneas, Vincent J. Lynch, Carole Ober, Marcelo A. Nobrega, John A. Kessler
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109138- (2021)
Summary: Various human diseases and pregnancy-related disorders reflect endometrial dysfunction. However, rodent models do not share fundamental biological processes with the human endometrium, such as spontaneous decidualization, and no existing hum
Externí odkaz:
https://doaj.org/article/f12da9fe6d524cb6bd0633fc2545a92b
Akademický článek
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Autor:
Karen M. Chapman, Gerardo A. Medrano, Priscilla Jaichander, Jaideep Chaudhary, Alexandra E. Waits, Marcelo A. Nobrega, James M. Hotaling, Carole Ober, F. Kent Hamra
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1828-1835 (2015)
Organisms with targeted genomic modifications are efficiently produced by gene editing in embryos using CRISPR/Cas9 RNA-guided DNA endonuclease. Here, to facilitate germline editing in rats, we used CRISPR/Cas9 to catalyze targeted genomic mutations
Externí odkaz:
https://doaj.org/article/3636e9614fd349e99ff5d4fa5d2528d2