Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Marcello Rasparini"'
Autor:
Maurizio Taddei, Marcello Rasparini, Fabrizio Manetti, Giuseppe Barreca, Luca Carcone, Elena Cini
Publikováno v:
European Journal of Organic Chemistry. 2018:2622-2628
Autor:
Katharina Gloria Hugentobler, Katherine E. Jolley, Lisa A. Thompson, A. John Blacker, Nicholas J. Turner, Marcello Rasparini
In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad98ce53178df0cd81771ae74e35da59
https://doi.org/10.1021/acs.oprd.6b00346
https://doi.org/10.1021/acs.oprd.6b00346
Autor:
Stephen Roseblade, Maurizio Taddei, Elena Cini, Adele Russo, Luca Carcone, Marcello Rasparini, Giuseppe Barreca, Hans Günter Nedden, Antonio Zanotti-Gerosa, Giovanni Marras, Giada Arena
Publikováno v:
Advanced Synthesis & Catalysis. 355:1449-1454
The novel rhodium complex [Rh(S)-Phanephos(cod)]-catalyzed hydrogenation of disubstituted (E)-enol acetate carboxylic acids is reported. The catalytic cycle works under 30 bar of hydrogen under conventional heating giving different 3-acetoxy-2,3-disu
Autor:
Rachel S. Heath, Nicholas J. Turner, Katharina Gloria Hugentobler, Humera H. Sharif, Marcello Rasparini
Publikováno v:
Hugentobler, K G, Sharif, H, Rasparini, M, Heath, R S & Turner, N J 2016, ' Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor ', Organic and Biomolecular Chemistry, vol. 14, no. 34, pp. 8064-8067 . https://doi.org/10.1039/c6ob01382a
Three complementary biocatalytic routes were examined for the synthesis of the cyclopropyl amine (1R,2S)-2, which is a key building block for the anti-thrombotic agent ticagrelor 1. By employing either a ketoreductase, amidase or lipase biocatalyst,
Autor:
Luca Banfi, Marcello Rasparini, Adele Russo, Fabrizio Manetti, Maurizio Taddei, Giuseppe Barreca, Stephen Roseblade, Romina Vitale, Antonio Zanotti-Gerosa, Elena Cini, Luciana Malpezzi, Renata Riva, Giovanni Marras, Luca Carcone
A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156bf77a1fd4770fffdd2b6e4107bfdd
http://hdl.handle.net/11567/847242
http://hdl.handle.net/11567/847242
Autor:
Gianluca Giorgi, Marcello Rasparini, Lucía Gandolfi Donadío, Maria Julieta Comin, Mariana Alejandra Galetti
Using the reaction between phenylacetaldehyde and nitrostyrene catalyzed by pyrrolidine as a simple model, we have studied the diastereochemical outcome of the organocatalytic Michael reactions between benzylic aldehydes and nitrostyrenes. We found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e86fe6be8f6a55855d5240e048ba334
http://hdl.handle.net/11365/1001758
http://hdl.handle.net/11365/1001758
Publikováno v:
The Journal of organic chemistry. 80(7)
Lipase mediated desymmetrization of a meso-diol (1,2-cyclopentanedimethanol) allows the synthesis of both enantiomers of some chiral aldehydes, whose behavior in Passerini and Ugi reactions has been explored. Exploiting these two complementary multic
Autor:
Ian R. Cooper, Ronald Grigg, Laura A. T. Cleghorn, Colin W. G. Fishwick, William S. MacLachlan, Marcello Rasparini, Visuvanathar Sridharan
Publikováno v:
Journal of Organometallic Chemistry. 687:483-493
A new general three-component Pd/In bimetallic cascade reaction with four synthetic variants involving aryl iodides, allenes and C=X compounds affording homoallylic alcohols/amines as products is described and exemplified for Class 1 processes (inter
Publikováno v:
European Journal of Organic Chemistry. 2003:1319-1336
In order to develop a general strategy for selective activation of designed enediyne prodrugs belonging to the “lactenediyne” family, we studied the scope of intramolecular transamidation of simple monocyclic β-lactams bearing a tethered amine.
Autor:
Novella Fossati, Marcello Rasparini, Luca Banfi, Katharine Ann Powles, Giuseppe Guanti, Carlo Scolastico
Publikováno v:
Tetrahedron: Asymmetry. 12:271-277
A new asymmetric synthesis of (R)-chlozolinate 1, an important antifungal agent, based on the enzymatic asymmetrization of diethyl 2-benzyloxy-2-methylmalonate, is reported.