Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Marcello Panagia"'
1
Akademický článek
SGLT2 inhibitor ertugliflozin decreases elevated intracellular sodium, and improves energetics and contractile function in diabetic cardiomyopathy
Autor: Dominique Croteau, Tomas Baka, Sara Young, Huamei He, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, David R. Pimentel, James A. Balschi, Wilson S. Colucci, Ivan Luptak
Publikováno v: Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114310- (2023)
Background: Elevated myocardial intracellular sodium ([Na+]i) was shown to decrease mitochondrial calcium ([Ca2+]MITO) via mitochondrial sodium/calcium exchanger (NCXMITO), resulting in decreased mitochondrial ATP synthesis. The sodium-glucose co-tra
Externí odkaz: https://doaj.org/article/ddbf2c50d47847a383f78995232ae6e7
Zobrazit plný text záznamu
2
Akademický článek
Effects of Sodium‐Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice
Autor: Dominique Croteau, Ivan Luptak, Jordan M. Chambers, Ion Hobai, Marcello Panagia, David R. Pimentel, Deborah A. Siwik, Fuzhong Qin, Wilson S. Colucci
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz: https://doaj.org/article/cb89ff2bb7ca44b79b60b9cd0761c0c1
Zobrazit plný text záznamu
3
Akademický článek
Fusion of deep learning models of MRI scans, Mini–Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment
Autor: Shangran Qiu, Gary H. Chang, Marcello Panagia, Deepa M. Gopal, Rhoda Au, Vijaya B. Kolachalama
Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 737-749 (2018)
Abstract Introduction Our aim was to investigate if the accuracy of diagnosing mild cognitive impairment (MCI) using the Mini–Mental State Examination (MMSE) and logical memory (LM) test could be enhanced by adding MRI data. Methods Data of individ
Externí odkaz: https://doaj.org/article/3086cfe72294429d91db39f9cefd77c5
Zobrazit plný text záznamu
4
Akademický článek
Galectin‐3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients
Autor: Deepa M. Gopal, Nir Ayalon, Yi‐Chih Wang, Deborah Siwik, Aaron Sverdlov, Courtney Donohue, Alejandro Perez, Jill Downing, Caroline Apovian, Vanessa Silva, Marcello Panagia, Vijaya Kolachalama, Jennifer E. Ho, Chang‐seng Liang, Noyan Gokce, Wilson S. Colucci
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 7 (2019)
Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease (MHD) in young obese patients would help identify high‐risk individuals for heart failure prevention s
Externí odkaz: https://doaj.org/article/67aace46baab412d89d4639149c23c25
Zobrazit plný text záznamu
7
Recapitulating aortic valve disease hemodynamics with a highly tunable bio-inspired soft robotic aortic sleeve
Autor: Christopher Nguyen, Adam Mauskapf, Yasufumi Nagata, J L Guerrero, Yiling Fan, Luca Rosalia, Jo Kim, Shi Chen, Ellen T. Roche, Robert A. Levine, Jaume Coll-Font, Robert Eder, Caglar Ozturk, Marcello Panagia
Existing models of aortic stenosis (AS) are limited to inducing left ventricular pressure overload. As they have reduced control over the severity of aortic constriction, the clinical relevance of these models is largely hindered by their inability t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5427fa2ea20a0065ee1e71f4d44deb
https://doi.org/10.21203/rs.3.rs-713582/v1
Zobrazit plný text záznamu
8
Effects of Sodium‐Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice
Autor: Ion A. Hobai, Wilson S. Colucci, Dominique Croteau, Deborah A. Siwik, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, Ivan Luptak, David R. Pimentel
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16203839faa370c679548b749eaa129
http://europepmc.org/articles/PMC8403324
Zobrazit plný text záznamu
10
Abstract 16641: The SGLT2 Inhibitor Ertugliflozin Induces Oxidative Phosphorylation Gene Expression and Improves Systolic Function Independent of Diabetes in Mice
Autor: Wilson S. Colucci, Jordan M. Chambers, David R. Pimentel, Deborah A. Siwik, Ivan Luptak, Fuzhong Qin, Ion A. Hobai, Jena B Goodman, Marcello Panagia, Dominique Croteau
Publikováno v: Circulation. 142
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent of diabetes. While animal studies suggest SGLT2i improve cardiac metabolism, the effect of SGLT2i on mitochondrial func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::745c6cf907599986b5cff1d79bd630c2
https://doi.org/10.1161/circ.142.suppl_3.16641
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje