Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marcello Clerici"'
Autor:
Lena Maria Muckenfuss, Anabel Carmen Migenda Herranz, Franziska Maria Boneberg, Marcello Clerici, Martin Jinek
Publikováno v:
eLife, Vol 11 (2022)
3′ end formation of most eukaryotic mRNAs is dependent on the assembly of a ~1.5 MDa multiprotein complex, that catalyzes the coupled reaction of pre-mRNA cleavage and polyadenylation. In mammals, the cleavage and polyadenylation specificity factor
Externí odkaz:
https://doaj.org/article/ebef09ef4efa4e47b141aa6204050d49
Publikováno v:
eLife, Vol 6 (2017)
3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specifici
Externí odkaz:
https://doaj.org/article/76eab6f362094dac98d604cc0095e4e0
Publikováno v:
Current Opinion in Structural Biology
Highlights • Integrated structural biology approaches have provided new insights into the mechanism of eukaryotic mRNA 3′-end processing. • The polymerase modules of yeast and human cleavage and polyadenylation factors share a conserved archite
Publikováno v:
Nature Structural & Molecular Biology
Mammalian mRNA biogenesis is dependent on specific recognition of a hexanucleotide AAUAAA motif in the polyadenylation signals (PAS) of pre-mRNA transcripts by the cleavage and polyadenylation specificity factor (CPSF) complex. Here we report a 3.1
Autor:
Titia K. Sixma, Michael T. Morgan, Cynthia Wolberger, Marie E. Morrow, Marcello Clerici, Katerina Growkova, Michal Simicek, David Komander, Ming Yan
A common strategy for studying the biological role of deubiquitinating enzymes (DUBs) in different pathways is to study the effects of replacing the wild type DUB with a catalytically inactive mutant in cells. We report here that a commonly studied D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6ed1d17a641bbf72459cce97bfc3f2
https://doi.org/10.1101/238154
https://doi.org/10.1101/238154
Autor:
Ke Jin, Z. Zhang, Marcello Clerici, Titia K. Sixma, Peter ten Dijke, Long Zhang, Maarten van Dinther, Fangfang Zhou, Rui Gao, Huizhe Huang, Feng Xie
Publikováno v:
EMBO Journal
EMBO Journal, 36(11), 1623-1639
EMBO Journal, 36(11), 1623-1639
SMAD4 is a common intracellular effector for TGF‐β family cytokines, but the mechanism by which its activity is dynamically regulated is unclear. We demonstrated that ubiquitin‐specific protease (USP) 4 strongly induces activin/BMP signaling by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da95fda4e9c68937a505782ff5857fa9
https://hdl.handle.net/1887/115147
https://hdl.handle.net/1887/115147
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, 6
eLife, Vol 6 (2017)
eLife, 6
3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specifici
Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2
Autor:
Aurélien Deniaud, Volker Boehm, Stephen Cusack, Niels H. Gehring, Marcello Clerici, Christiane Schaffitzel
Publikováno v:
'Nucleic Acids Research ', vol: 42, pages: 2673-2686 (2014)
Nucleic Acids Research
Nucleic Acids Research
Nonsense-mediated decay (NMD) is a eukaryotic quality control pathway, involving conserved proteins UPF1, UPF2 and UPF3b, which detects and degrades mRNAs with premature stop codons. Human UPF2 comprises three tandem MIF4G domains and a C-terminal UP