Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marcella T. Clayton"'
Autor:
Justin C. Smith, Samuel Dean Larsen, Leland Otto Weigel, Jeffrey A. Ward, Ryan J. Linder, Susan M. Reutzel-Edens, Perry Clark Heath, Stanley P. Kolis, Marvin M. Hansen, Marcella T. Clayton, Sandra S. K. Borders, Shella Lenyonga Tameze
Publikováno v:
Organic Process Research & Development. 13:198-208
An efficient and scalable synthesis of the clinical candidate 1 is described. The first-generation synthesis built the enantioenriched nitro-aminoindanol core from 6-nitroindanone using a five-step literature route. The second-generation route used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228e4c59294cf55a0c3b7b98aba7b55d
https://doi.org/10.1021/op800243q
https://doi.org/10.1021/op800243q
Autor:
Rima S. Al-awar, Michael E. LeTourneau, Marcella T. Clayton, Steven Wayne Pedersen, D. Scott Coffey, James Edward Ray, Thomas A. Engler, Sushant Malhotra, John L. Grutsch, Michael John Martinelli, Joseph Matthew Pawlak, Stanley P. Kolis, Kevin A. Sullivan, Margaret M. Faul, Kelly Wayne Furness
Publikováno v:
The Journal of Organic Chemistry. 69:2967-2975
Synthesis of indolo[6,7-a]pyrrolo[3,4-c]carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2, will be described. Two approaches to the synthesis of 2 were identified that required new meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37eb9dd72e993b68b945c14cc7332a64
https://doi.org/10.1021/jo035606v
https://doi.org/10.1021/jo035606v
Autor:
Steven Wayne Pedersen, Yao-Chang Xu, Marvin M. Hansen, Sandra S. Keast, Godfrey Alexander Glenn, John L. Grutsch, Marcella T. Clayton, Daniel Timothy Kohlman, Andreea R. McSpadden, Jeffrey A. Ward
Publikováno v:
Synlett. :1351-1354
2-Trimethylsilyl protection of benzothiophenes and benzofurans prevents anion migration to the 2-position when lithiated species are formed. These lithiated benzothiophenes and benzofurans provide superior results in additions to piperidones. Deprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f654013a1b36edb64f1ccc153d2a6f
https://doi.org/10.1055/s-2004-825609
https://doi.org/10.1055/s-2004-825609
Autor:
Marcella T. Clayton, Mahmoud Hassan, Folahan O. Ayorinde, Voneil N. Parchment, Kent A. A. Bryant, Chukwuma P. Nwaonicha
Publikováno v:
Journal of the American Oil Chemists’ Society. 70:129-132
cis-12,13-Epoxy-cis-octadecenoic (vernolic) acid occurs in triglycerides of the seed oil ofVernonia galamensis. The seeds also contain a lipase capable of hydrolyzing the triglycerides. Previous investigators incubated the seed ofVernonia anthelminti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11664789f044676f071cb966b8c62cce
https://doi.org/10.1007/bf02542614
https://doi.org/10.1007/bf02542614
Publikováno v:
ChemInform. 34
A procedure for the synthesis of 7-cyano and 7-acetamido indoles via cyanocarbonation/hydrogenation of 7-formyl indole is presented. The process can be efficiently scaled up to provide multigram quantities of the desired compounds in good yield. A sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c574e8bf142fdfddc19815909dbbdb
https://doi.org/10.1002/chin.200342049
https://doi.org/10.1002/chin.200342049
Autor:
Marvin M. Hansen, Sandra S. K. Borders, Marcella T. Clayton, Perry C. Heath, Stanley P. Kolis, Samuel D. Larsen, Ryan J. Linder, Susan M. Reutzel-Edens, Justin C. Smith, Shella L. Tameze, Jeffrey A. Ward, Leland O. Weigel
Publikováno v:
Organic Process Research & Development; Mar2009, Vol. 13 Issue 2, p198-208, 11p