Výsledky vyhledávání - "Marcella Marcellini"

The Biflavonoid Amentoflavone Inhibits Neovascularization Preventing the Activity of Proangiogenic Vascular Endothelial Growth Factors

Autor: Laura Tudisco, Claudio Pisano, Fabrizio Dal Piaz, Salvatore Ponticelli, Peter Roepstorff, Frederik W. Lund, Augusto Orlandi, Valeria Tarallo, Marcella Marcellini, Nunziatina De Tommasi, Laura Lepore, Sandro De Falco

Publikováno v: The Journal of Biological Chemistry
The Journal of biological chemistry
286 (2011): 19641–19651. doi:10.1074/jbc.M110.186239
info:cnr-pdr/source/autori:Tarallo V, Lepore L, Marcellini M, Dal Piaz F, Tudisco L, Ponticelli S, Wendelboe Lund F, Roepstorff P, Orlandi A, Pisano C, De Tommasi N, and De Falco S./titolo:The biflavonoid Amentoflavone inhibits neovascularization preventing the activity of pro-angiogenic vascular endothelial growth factors/doi:10.1074%2Fjbc.M110.186239/rivista:The Journal of biological chemistry (Print)/anno:2011/pagina_da:19641/pagina_a:19651/intervallo_pagine:19641–19651/volume:286
Tarallo, V, Lepore, L, Marcellini, M, Dal Piaz, F, Tudisco, L, Ponticelli, S, Lund, F W, Roepstorff, P, Orlandi, A, Pisano, C, De Tommasi, N & De Falco, S 2011, ' The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors ', Journal of Biological Chemistry, vol. 286, no. 22, pp. 19641-51 . https://doi.org/10.1074/jbc.M110.186239

The proangiogenic members of VEGF family and related receptors play a central role in the modulation of pathological angiogenesis. Recent insights indicate that, due to the strict biochemical and functional relationship between VEGFs and related rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5e2de71469baaa66a7863b2a3823e4
https://doi.org/10.1074/jbc.m110.186239

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Propionyl-L-carnitine Reduces Proliferation and Potentiates Bax-related Apoptosis of Aortic Intimal Smooth Muscle Cells by Modulating Nuclear Factor-κB Activity

Autor: Arianna Francesconi, Luigi Giusto Spagnoli, Antonio Di Lascio, Marcella Marcellini, Augusto Orlandi

Publikováno v: Journal of Biological Chemistry. 282:4932-4942

Propionyl-l-carnitine (PLC) has been introduced among the therapeutic approaches of peripheral arterial disease, and more recently, an increase of intimal cell apoptosis has been demonstrated to contribute to its effectiveness in rabbit carotid posti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e4edebd0f418d9962797ce75534bf
https://doi.org/10.1074/jbc.m606148200

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Role of ageing and coronary atherosclerosis in the development of cardiac fibrosis in the rabbit

Autor: Luigi Giusto Spagnoli, Amedeo Ferlosio, Augusto Orlandi, Arianna Francesconi, Marcella Marcellini

Publikováno v: Cardiovascular Research. 64:544-552

Objective : Myocardial fibrosis contributes to the impairing of cardiac function and characterizes ageing, but is also a consequence of atherosclerotic ischemic disease. Since atherosclerosis is a slow progressive disease, which prevails in elderly p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0f35bada839512ef0b5f0f60342831
https://doi.org/10.1016/j.cardiores.2004.07.024

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Propionyl-l-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells

Autor: Daniela Pesce, Menotti Calvani, Augusto Orlandi, Luigi Giusto Spagnoli, Marcella Marcellini

Publikováno v: Atherosclerosis. 160:81-89

Previously we documented that propionyl- l -carnitine (PLC) reduces the growth of atherosclerotic lesions in cholesterol-fed aged rabbits in association with a decrease of plaque smooth muscle cell (SMC) proliferation and plasma triglycerides. To cla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f3b8c3ae907d814ef255da6b2478de
https://doi.org/10.1016/s0021-9150(01)00568-8

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The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2

Autor: David F. Holmes, Giovanni Salvatori, Thomas A. Jowitt, David Briggs, Anthony J. Day, Marcella Marcellini, Antonio Inforzato, Vincenzo Rivieccio, Ragnar Lindstedt, Barbara Bottazzi, Karl E. Kadler, Clair Baldock, Antonio Verdoliva, Alberto Mantovani

Publikováno v: The Journal of biological chemistry. 285(23)

The inflammation-associated long pentraxin PTX3 plays key roles in innate immunity, female fertility, and vascular biology (e.g. it inhibits FGF2 (fibroblast growth factor 2)-mediated angiogenesis). PTX3 is composed of multiple protomers, each compos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9809ce16df8fe915070c22a0d870cceb
https://pubmed.ncbi.nlm.nih.gov/32034013

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Propionyl-L-carnitine improves post-ischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production

Autor: Maria Giovanna Scioli, Luigi Giusto Spagnoli, Gaetano Arcuri, Giovan Giuseppe Mattera, Sandro De Falco, Claudio Pisano, Marcella Marcellini, Franco Borsini, Katia Lombardo, Teresa Riccioni, Maria Antonietta Stasi, Augusto Orlandi

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology 30 (2010): 426–435. doi:10.1161/ATVBAHA.109.201533
info:cnr-pdr/source/autori:Stasi MA, Mattera G, Scioli MG, Lombardo K, Arcuri G, Riccioni T, De Falco S, Pisano C, Spagnoli LG, Borsini F, Orlandi A./titolo:Propionyl-L-carnitine improves post-ischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production/doi:10.1161%2FATVBAHA.109.201533/rivista:Arteriosclerosis, thrombosis, and vascular biology/anno:2010/pagina_da:426/pagina_a:435/intervallo_pagine:426–435/volume:30

Objective— The beneficial effect of the natural compound propionyl- l -carnitine (PLC) on intermittent claudication in patients with peripheral arterial disease is attributed to its anaplerotic function in ischemic tissues, but inadequate informati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7402ef5dfb7963b857b82ff7e8851ee7
http://www.cnr.it/prodotto/i/26962

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Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity

Autor: Daniele Simoni, Riccardo Rondanin, Michele Rizzi, Giuseppe Giannini, Giuseppina Grisolia, Domenico Alloatti, Marcella Marcellini, Riccardo Baruchello, Manlio Tolomeo, Claudio Pisano, Marco Eleopra, Romeo Romagnoli, Massimo Castorina

A novel class of combretastatins, modified at A-ring or both A- and B-rings, mainly by replacement with benzofuran or benzo[b]thiophene, were synthesized. The new heterocombretastatins showed good cytotoxic activity on BMEC and H-460 cell lines. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0847b65fd609134fb8498536d3abdc31
http://hdl.handle.net/11392/529727

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Synthesis and biological activity of fluorinated combretastatin analogues

Autor: Andrea Ciacci, Giuseppe Giannini, Marcella Marcellini, Mauro Marzi, Paolo Carminati, Claudio Pisano, Teresa Riccioni, M. Ornella Tinti, Isabella Lustrati, Domenico Alloatti, Mario B. Guglielmi, Walter Cabri, Grazia Gallo

With the aim of understanding the influence of fluorine on the double bond of the cis-stilbene moiety of combretastatin derivatives and encouraged by a preliminary molecular modeling study showing a different biological environment on the interaction

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http://hdl.handle.net/11585/756794

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Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit

Autor: Marcella Marcellini, Claudio Pisano, Arianna Francesconi, Amedeo Ferlosio, Augusto Orlandi, Antonio Di Lascio, Luigi Giusto Spagnoli

Publikováno v: Journal of cardiovascular pharmacology. 50(2)

Age-related cardiac remodeling is characterized by changes in myocardial structure, which include fibrosis (ie, increased collagen concentration). The pathogenetic mechanisms of age-related cardiac changes and possible pharmacologic interventions are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf74338a6e85e6cc40db7d2723aa632
https://pubmed.ncbi.nlm.nih.gov/17703133

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