Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Marcella Ma"'
Autor:
Ming Yang, Tamana Darwish, Pierre Larraufie, Debra Rimmington, Irene Cimino, Deborah A. Goldspink, Benjamin Jenkins, Albert Koulman, Cheryl A. Brighton, Marcella Ma, Brian Y. H. Lam, Anthony P. Coll, Stephen O’Rahilly, Frank Reimann, Fiona M. Gribble
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body weight, the mechanisms of action are still elusive. Recent studies have identified the gastrointestinal tract as an important site of action. Here we u
Externí odkaz:
https://doaj.org/article/3277fbedd1ef4a0488a75dc21d27c7a7
Autor:
Constanze M Hammerle, Ionel Sandovici, Gemma V Brierley, Nicola M Smith, Warren E Zimmer, Ilona Zvetkova, Haydn M Prosser, Yoichi Sekita, Brian Y H Lam, Marcella Ma, Wendy N Cooper, Antonio Vidal-Puig, Susan E Ozanne, Gema Medina-Gómez, Miguel Constância
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009069 (2020)
The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific manner, are known to have important roles in development, growth and metabolism. However,
Externí odkaz:
https://doaj.org/article/dd9ff8b3a079402997344c273ba5478c
Autor:
Benjamin G Challis, Andrew S Powlson, Ruth T Casey, Carla Pearson, Brian Y Lam, Marcella Ma, Deborah Pitfield, Giles S H Yeo, Edmund Godfrey, Heok K Cheow, V Krishna Chatterjee, Nicholas R Carroll, Ashley Shaw, John R Buscombe, Helen L Simpson
Publikováno v:
Endocrine Connections, Vol 6, Iss 7, Pp 489-497 (2017)
Objective: In adults with hyperinsulinaemic hypoglycaemia (HH), in particular those with insulinoma, the optimal diagnostic and management strategies remain uncertain. Here, we sought to characterise the biochemical and radiological assessment, and c
Externí odkaz:
https://doaj.org/article/5e4a457eaf8b49049ef3637d4624361e
Autor:
Y.C. Loraine Tung, Pawan Gulati, Che-Hsiung Liu, Debra Rimmington, Rowena Dennis, Marcella Ma, Vladimir Saudek, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo
Publikováno v:
Molecular Metabolism, Vol 4, Iss 4, Pp 287-298 (2015)
Objective: Loss of function FTO mutations significantly impact body composition in humans and mice, with Fto-deficient mice reported to resist the development of obesity in response to a high-fat diet (HFD). We aimed to further explore the interactio
Externí odkaz:
https://doaj.org/article/d16fdc78041448f683f99844d85e3079
Autor:
Padraic G. Fallon, Betania Mahler-Araujo, Martin Dale, Anne-Claire Guénantin, Guillaume Bidault, Aurelien Dugourd, Marcella Ma, Arthur Kaser, Stefania Carobbio, Jennifer Leggat, Julio Saez-Rodriguez, Helen E. Jolin, Andrew N J McKenzie, Kasparas Petkevicius, Brian Y H Lam, Samuel Virtue, Antonio Vidal-Puig
Publikováno v:
Nature Metabolism. 3:1150-1162
Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation1. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites2, improving insulin se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d369c0919c8e33d03fb561a2b2d7fe26
https://doi.org/10.1038/s42255-021-00440-5
https://doi.org/10.1038/s42255-021-00440-5
Autor:
Simon Bond, Joseph Cheriyan, Jean-Sébastien Silvestre, Brian Y.H. Lam, Yanyi Sun, James H.F. Rudd, Yuning Lu, Marcella Ma, Ziad Mallat, Meritxell Nus, James Harrison, Rouchelle Sriranjan, Andrew S. Sage, Xian Yu, Stephen A. Newland, Tian X. Zhao, Xiang Cheng
Publikováno v:
Journal of the American College of Cardiology. 78:1127-1142
BACKGROUND: Innate lymphoid cells type 2 (ILC2s) play critical homeostatic functions in peripheral tissues. ILC2s reside in perivascular niches and limit atherosclerosis development. OBJECTIVES: ILC2s also reside in the pericardium but their role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b07755d03b10bcf70102a869a933313
https://doi.org/10.1016/j.jacc.2021.07.018
https://doi.org/10.1016/j.jacc.2021.07.018
Autor:
Joycelyn Tan, Sam Virtue, Dougall M. Norris, Olivia J. Conway, Ming Yang, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R. Krycer, Richard J. Mills, Conceição Pereira, Martin Dale, Amber S. Shun-Shion, Harry J. M. Baird, James A. Horscroft, Alice P. Sowton, Marcella Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J. Murray, David C. Gershlick, James E. Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J. Fazakerley
SUMMARYCell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe7ad781bc0666a5a17fe82ad499dc9
https://doi.org/10.1101/2022.11.29.516437
https://doi.org/10.1101/2022.11.29.516437
Marginal Zone B cells produce 'natural' atheroprotective IgM antibodies in a T-cell-dependent manner
Autor:
James Harrison, Stephen Newland, Wei Jiang, Xiaohui Zhao, Marc Clement, Leanne Masters, Andrej Corovic, Xian Zhang, Fabrizio Drago, Marcella Ma, Maria Ozsvar Kozma, Froher Yasin, Yuta Saady, Hema Kothari, Tian Zhao, Guo-Ping Shi, Coleen McNamara, Christoph Binder, Andrew Sage, Jason Tarkin, Ziad Mallat, Meritxell Nus
The adaptive immune response plays an important role in atherosclerosis. In response to a high fat/high cholesterol diet, marginal zone B (MZB) cells activate an atheroprotective programme by regulating the differentiation and accumulation of T folli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4de193590e1eacce9a539c347f5b996
https://doi.org/10.21203/rs.3.rs-1753743/v1
https://doi.org/10.21203/rs.3.rs-1753743/v1
Autor:
Elena Dalle Vedove, Alessia Benvenga, Gianluca Nicolai, Marcella Massimini, Maria Veronica Giordano, Francesco Di Pierro, Benedetta Bachetti
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Establishing the contextIntestinal dysbiosis is a significant concern among dog owners, and the gut health of pets is an emerging research field. In this context, the Simulator of the Canine Intestinal Microbial Ecosystem (SCIME™) was recently deve
Externí odkaz:
https://doaj.org/article/e9ed5086ca49488aa18d0c499af9e8a9
Autor:
I. Sadaf Farooqi, Marcella Ma, Ilona Zvetkova, Brian Y.H. Lam, Irene Cimino, Luca Fagnocchi, Pierre Larraufie, Y. C. Loraine Tung, Giles S.H. Yeo, Debra Rimmington, J. Andrew Pospisilik, Frank Reimann, Richard G. Kay, Stephen O'Rahilly, Vladimir Saudek, Anthony P. Coll, Samuel Virtue, Fiona M. Gribble, Katherine Lawler, Antonio Vidal-Puig
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.17571. ⟨10.1038/s41598-021-96278-8⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.17571. ⟨10.1038/s41598-021-96278-8⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d088788e1b0eaa466fd29d1a0b198f0
https://hal-agroparistech.archives-ouvertes.fr/hal-03449868/file/41598_2021_Article_96278.pdf
https://hal-agroparistech.archives-ouvertes.fr/hal-03449868/file/41598_2021_Article_96278.pdf