Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib.

Autor: Tamer B Shabaneh, Sondra L Downey, Ayrton L Goddard, Michael Screen, Marcella M Lucas, Alan Eastman, Alexei F Kisselev

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56132 (2013)

The proteasome inhibitor bortezomib (Velcade) is prescribed for the treatment of multiple myeloma. Clinically achievable concentrations of bortezomib cause less than 85% inhibition of the chymotrypsin-like activity of the proteasome, but little atten

Externí odkaz: https://doaj.org/article/d150bdbd6bd641dda9f8a08422b25fc4

Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus

Autor: Willie Curry, Marcella M. Lucas, Amanda E. Hernan, J. Matthew Mahoney, Gregory R. Richard, Gregory L. Holmes, Andrew Massey, Rod C. Scott

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0191488 (2018)

Neurodevelopmental insults such as malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. Animals with MCDs have impairments in spatial cognition that, remarkably, are improved by p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4034a30736509ae0e2dc89d4242878
http://europepmc.org/articles/PMC5796690

Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib

Autor: Alexei F. Kisselev, Michael Screen, Alan Eastman, Tamer B. Shabaneh, Marcella M. Lucas, Sondra L. Downey, Ayrton L. Goddard

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56132 (2013)
PLoS ONE

The proteasome inhibitor bortezomib (Velcade) is prescribed for the treatment of multiple myeloma. Clinically achievable concentrations of bortezomib cause less than 85% inhibition of the chymotrypsin-like activity of the proteasome, but little atten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58499578530d0f4309ab111af9dbc24c
http://europepmc.org/articles/PMC3584083?pdf=render

Enrichment and Training Improve Cognition in Rats with Cortical Malformations

Autor: Rod C. Scott, Jeremy M. Barry, Kyle Jenks, Ben A. Duffy, Ashlee A. Robbins, Marcella M. Lucas, Barjor Gimi

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e84492 (2013)

Children with malformations of cortical development (MCD) frequently have associated cognitive impairments which reduce quality of life. We hypothesized that cognitive deficits associated with MCD can be improved with environmental manipulation or ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2503b38f2c16aa2f256ac5b9351da1d8
https://doi.org/10.1371/journal.pone.0084492

Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.

Autor: Jellett AP; Department of Neurology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; University of Bath, Biology and Biochemistry, Bath BA2 7AY, UK., Jenks K; Department of Neurology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA., Lucas M; Department of Neurology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA., Scott RC; University College London, Institute of Child Health, London WC1N 1EH, UK; Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, VT 05405, USA. Electronic address: rodney.scott@med.uvm.edu.

Publikováno v: Epilepsy research [Epilepsy Res] 2015 Feb; Vol. 110, pp. 88-94. Date of Electronic Publication: 2014 Nov 21.