Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marcella Laschi"'
Autor:
Lia Millucci, Lorenzo Ghezzi, Eugenio Paccagnini, Giovanna Giorgetti, Cecilia Viti, Daniela Braconi, Marcella Laschi, Michela Geminiani, Patrizia Soldani, Pietro Lupetti, Maurizio Orlandini, Chiara Benvenuti, Federico Perfetto, Adriano Spreafico, Giulia Bernardini, Annalisa Santucci
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
Background. Alkaptonuria, a rare autosomal recessive metabolic disorder caused by deficiency in homogentisate 1,2-dioxygenase activity, leads to accumulation of oxidised homogentisic acid in cartilage and collagenous structures present in all organs
Externí odkaz:
https://doaj.org/article/082681620fef4f64859f18f7f351bba9
Autor:
Lia Millucci, Eugenio Paccagnini, Lorenzo Ghezzi, Giulia Bernardini, Daniela Braconi, Marcella Laschi, Marco Consumi, Adriano Spreafico, Piero Tanganelli, Pietro Lupetti, Agnese Magnani, Annalisa Santucci
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21870 (2011)
AIMS: Atrial Natriuretic Peptide (ANP)-containing amyloid is frequently found in the elderly heart. No data exist regarding ANP aggregation process and its link to pathologies. Our aims were: i) to experimentally prove the presumptive association of
Externí odkaz:
https://doaj.org/article/b94ac125016d4a81b529169c881026b5
Autor:
Adriano Spreafico, Pietro Lupetti, Annalisa Santucci, Barbara Marzocchi, Daniela Braconi, Michela Geminiani, Giulia Bernardini, Maurizio Orlandini, Cecilia Viti, Giovanna Giorgetti, Lia Millucci, Marcella Laschi, Bruno Frediani
Publikováno v:
Calcified Tissue International. 101:50-64
Alkaptonuria (AKU) is a hereditary disorder that results from altered structure and function of homogentisate 1,2 dioxygenase (HGD). This enzyme, predominantly produced by liver and kidney, is responsible for the breakdown of homogentisic acid (HGA),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4081b4956dab983bf3dcaf534e2832
https://doi.org/10.1007/s00223-017-0260-9
https://doi.org/10.1007/s00223-017-0260-9
Autor:
Pietro Lupetti, Lucia Mazzi, Marcella Laschi, Giulia Bernardini, Giulia Collodel, Lia Millucci, Silvia Gambassi, Barbara Marzocchi, Michela Geminiani, Bruno Frediani, Daniela Braconi, Annalisa Santucci
Publikováno v:
Journal of Cellular Physiology. 232:1728-1738
Alkaptonuria (AKU) is an ultra-rare autosomal genetic disorder caused by a defect in the activity of the enzyme homogentisate 1,2-dioxygenase (HGD) that leads to the accumulation of homogentisic acid (HGA) and its oxidized product, benzoquinone aceti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a85d7930f560366407c8b435c364c4
https://doi.org/10.1002/jcp.25500
https://doi.org/10.1002/jcp.25500
Autor:
Michela Geminiani, Maurizio Orlandini, Daniela Braconi, Bruno Frediani, Silvia Gambassi, Marcella Laschi, Barbara Marzocchi, Federico Galvagni, Lia Millucci, Giulia Bernardini, Annalisa Santucci
Publikováno v:
Journal of Inherited Metabolic Disease. 39:801-806
Alkaptonuria (AKU) is a rare genetic disease that affects the entire joint. Current standard of AKU treatment is palliative and little is known about its physiopathology. Neovascularization is involved in the pathogenesis of systemic inflammatory rhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914c9becc666189adfe25b61e0f32a97
https://doi.org/10.1007/s10545-016-9976-3
https://doi.org/10.1007/s10545-016-9976-3
Autor:
Michela Geminiani, Barbara Marzocchi, Fabrizio Manetti, Giulia Bernardini, Daniela Braconi, Lia Millucci, Elena Dreassi, Marcella Laschi, Maurizio Botta, Annalisa Santucci
Publikováno v:
ChemMedChem. 11:674-678
Alkaptonuria (AKU) is a rare multisystem metabolic disease caused by deficient activity of homogentisate 1,2-dioxygenase (HGD), which leads to the accumulation of homogentisic acid (HGA). Currently, there is no treatment for AKU. The sole drug with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbe423b8db20cdc5d601c52cdb34f46
https://doi.org/10.1002/cmdc.201500578
https://doi.org/10.1002/cmdc.201500578
Autor:
Giulia Bernardini, Elena Petricci, Fabrizio Manetti, Barbara Marzocchi, Annalisa Santucci, Michela Geminiani, Silvia Gambassi, Maurizio Taddei, Maurizio Orlandini, Marcella Laschi
Osteosarcoma (OS) is an ultra-rare highly malignant tumor of the skeletal system affecting mainly children and young adults and it is characterized by an extremely aggressive clinical course. OS patients are currently treated with chemotherapy and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013f03e0234e792a77d56c45c74853f3
http://hdl.handle.net/11365/1034671
http://hdl.handle.net/11365/1034671
Establishment of Four New Human Primary Cell Cultures from Chemo-Naïve Italian Osteosarcoma Patients
Autor:
Alessandro Franchi, Bruno Frediani, Domenico Andrea Campanacci, Lia Millucci, Michela Geminiani, Marcella Laschi, Lorenzo Ghezzi, Loredana Amato, Annalisa Santucci, Daniela Braconi, Rodolfo Capanna, Adriano Spreafico, Giulia Bernardini
Publikováno v:
Journal of Cellular Physiology. 230:2718-2727
Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f07a4695330d1d26d00041bbee8cc0b8
https://doi.org/10.1002/jcp.24996
https://doi.org/10.1002/jcp.24996
Autor:
Michela, Geminiani, Silvia, Gambassi, Lia, Millucci, Pietro, Lupetti, Giulia, Collodel, Lucia, Mazzi, Bruno, Frediani, Daniela, Braconi, Barbara, Marzocchi, Marcella, Laschi, Giulia, Bernardini, Annalisa, Santucci
Alkaptonuria (AKU) is an ultra-rare autosomal genetic disorder caused by a defect in the activity of the enzyme homogentisate 1,2-dioxygenase (HGD) that leads to the accumulation of homogentisic acid (HGA) and its oxidized product, benzoquinone aceti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1eee22b5d58fc3659167e88c60348892
https://hdl.handle.net/11365/996342
https://hdl.handle.net/11365/996342
Autor:
Marcella Laschi, Michela Geminiani, Daniela Braconi, Alessandro Paffetti, Barbara Marzocchi, Giulia Bernardini, Lia Millucci, Annalisa Santucci, Bruno Frediani
Publikováno v:
The international journal of biochemistrycell biology. 81
Alkaptonuria (AKU) is an ultra-rare inborn error of metabolism associated with a defective catabolism of phenylalanine and tyrosine leading to increased systemic levels of homogentisic acid (HGA). Excess HGA is partly excreted in the urine, partly ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418a3397bf5b81f1d0055cc70f3ef61a
https://pubmed.ncbi.nlm.nih.gov/27590860
https://pubmed.ncbi.nlm.nih.gov/27590860