Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Marcella Cesana"'
Autor:
Daniela Cesana, Maria Pia Cicalese, Andrea Calabria, Pietro Merli, Roberta Caruso, Monica Volpin, Laura Rudilosso, Maddalena Migliavacca, Federica Barzaghi, Claudia Fossati, Francesco Gazzo, Simone Pizzi, Andrea Ciolfi, Alessandro Bruselles, Francesca Tucci, Giulio Spinozzi, Giulia Pais, Fabrizio Benedicenti, Matteo Barcella, Ivan Merelli, Pierangela Gallina, Stefania Giannelli, Francesca Dionisio, Serena Scala, Miriam Casiraghi, Luisa Strocchio, Luciana Vinti, Lucia Pacillo, Eleonora Draghi, Marcella Cesana, Sara Riccardo, Chiara Colantuono, Emmanuelle Six, Marina Cavazzana, Filippo Carlucci, Manfred Schmidt, Caterina Cancrini, Fabio Ciceri, Luca Vago, Davide Cacchiarelli, Bernhard Gentner, Luigi Naldini, Marco Tartaglia, Eugenio Montini, Franco Locatelli, Alessandro Aiuti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Hematopoietic stem cell gene therapy (GT) using a γ-retroviral vector (γ-RV) is an effective treatment for Severe Combined Immunodeficiency due to Adenosine Deaminase deficiency. Here, we describe a case of GT-related T-cell acute lymphobl
Externí odkaz:
https://doaj.org/article/319bd86d084c40b6be16ee73e0b5af1a
EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation.
Autor:
Marcella Cesana, Gennaro Tufano, Francesco Panariello, Nicolina Zampelli, Susanna Ambrosio, Rossella De Cegli, Margherita Mutarelli, Lorenzo Vaccaro, Micheal J Ziller, Davide Cacchiarelli, Diego L Medina, Andrea Ballabio
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3002034 (2023)
The stress-responsive transcription factor EB (TFEB) is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. TFEB is regulated at the posttranslational level by the nutrient-sensitive
Externí odkaz:
https://doaj.org/article/0a0a0c0eeb834eddadd29d0c1f98b256
Autor:
Vladimir Nosi, Alessandrì Luca, Melissa Milan, Maddalena Arigoni, Silvia Benvenuti, Davide Cacchiarelli, Marcella Cesana, Sara Riccardo, Lucio Di Filippo, Francesca Cordero, Marco Beccuti, Paolo M. Comoglio, Raffaele A. Calogero
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4217 (2021)
Background: Disruption of alternative splicing (AS) is frequently observed in cancer and might represent an important signature for tumor progression and therapy. Exon skipping (ES) represents one of the most frequent AS events, and in non-small cell
Externí odkaz:
https://doaj.org/article/a2366495b02d45b1b1942f37ca42d51b
Autor:
Carlos A. Aguilar, Ramona Pop, Anna Shcherbina, Alain Watts, Ronald W. Matheny Jr., Davide Cacchiarelli, Woojin M. Han, Eunjung Shin, Shadi A. Nakhai, Young C. Jang, Christopher T. Carrigan, Casey A. Gifford, Melissa A. Kottke, Marcella Cesana, Jackson Lee, Maria L. Urso, Alexander Meissner
Publikováno v:
Stem Cell Reports, Vol 7, Iss 5, Pp 983-997 (2016)
Following injury, adult skeletal muscle undergoes a well-coordinated sequence of molecular and physiological events to promote repair and regeneration. However, a thorough understanding of the in vivo epigenomic and transcriptional mechanisms that co
Externí odkaz:
https://doaj.org/article/ba01f4c08736496d9ecd22fa163ac9bd
Publikováno v:
Cells, Vol 9, Iss 5, p 1186 (2020)
The MiT/TFE family of transcription factors (MITF, TFE3, and TFEB), which control transcriptional programs for autophagy and lysosome biogenesis have emerged as regulators of energy metabolism in cancer. Thus, their activation increases lysosomal cat
Externí odkaz:
https://doaj.org/article/9177d5d42b5d4ad3bfa972399ed09ecc
Autor:
Juli J. Unternaehrer, Rui Zhao, Kitai Kim, Marcella Cesana, John T. Powers, Sutheera Ratanasirintrawoot, Tamer Onder, Tsukasa Shibue, Robert A. Weinberg, George Q. Daley
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 691-698 (2014)
Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-m
Externí odkaz:
https://doaj.org/article/2ceafcf7bcea42f9b4f7de18552eddaf
Autor:
Elena Carbognin, Valentina Carlini, Francesco Panariello, Martina Chieregato, Elena Guerzoni, Davide Benvegnù, Valentina Perrera, Cristina Malucelli, Marcella Cesana, Antonio Grimaldi, Margherita Mutarelli, Annamaria Carissimo, Eitan Tennenbaum, Hillel Kugler, Jamie A. Hackett, Davide Cacchiarelli, Graziano Martello
Pluripotency is the potential of a single cell to give rise to all embryonic lineages and first emerges in the naïve epiblast of the preimplantation embryo. Upon implantation, epiblast cells transit to a formative phase, which is preparatory for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::610437bc28e384949f6304db19171820
https://hdl.handle.net/11588/908602
https://hdl.handle.net/11588/908602
Autor:
Elena Carbognin, Valentina Carlini, Francesco Panariello, Martina Chieregato, Elena Guerzoni, Davide Benvegnù, Valentina Perrera, Cristina Malucelli, Marcella Cesana, Antonio Grimaldi, Margherita Mutarelli, Annamaria Carissimo, Eitan Tannenbaum, Hillel Kugler, Jamie A. Hackett, Davide Cacchiarelli, Graziano Martello
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdfb351bcc4a08a5cdabec826ecb6eb
https://hdl.handle.net/11577/3474787
https://hdl.handle.net/11577/3474787
Autor:
Jlenia Monfregola, Pier Paolo Di Fiore, Maria Matarese, Marcella Cesana, Lukas A. Huber, Angela Zampelli, Salvatore Pece, Giovanni Bertalot, Mariana E. G. de Araujo, Taras Stasyk, Edoardo Nusco, Chiara Di Malta, Diletta Siciliano, Alessandro Venuta, Gennaro Napolitano, Claudia Vilardo, Valerio Benedetti, Alessia Calcagni, Alessandra Esposito, Andrea Ballabio
Publikováno v:
Nature
The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates1–3. However, whether mTORC1 responds to diverse stimuli b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28322620ad4d4c101de6a8925d72cd5
https://doi.org/10.1038/s41586-020-2444-0
https://doi.org/10.1038/s41586-020-2444-0
Autor:
Maddalena Arigoni, Paolo M. Comoglio, Francesca Cordero, Vladimir Nosi, Alessandrì Luca, Silvia Benvenuti, Sara Riccardo, Raffaele A. Calogero, Marcella Cesana, Marco Beccuti, Davide Cacchiarelli, Lucio Di Filippo, Melissa Milan
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 4217, p 4217 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 4217, p 4217 (2021)
Background: Disruption of alternative splicing (AS) is frequently observed in cancer and might represent an important signature for tumor progression and therapy. Exon skipping (ES) represents one of the most frequent AS events, and in non-small cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060ff7d685743f48be64a6cd274f3926
https://pubmed.ncbi.nlm.nih.gov/33921709
https://pubmed.ncbi.nlm.nih.gov/33921709