Výsledky vyhledávání - "Marcella C.F. Dalm"

Multivariate data analysis as a PAT tool for early bioprocess development data

Autor: Marcella C.F. Dalm, Mathieu Streefland, Bas Diepenbroek, René H. Wijffels, Sarah M. Mercier

Publikováno v: Journal of Biotechnology, 167(13), 262-270
Journal of Biotechnology 167 (2013) 13

Early development datasets are typically unstructured, incomplete and truncated, yet they are readily available and contain relevant process information which is not extracted using classical data analysis techniques. In this paper, we illustrate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a464b370575473868d03578edbff4b91
https://doi.org/10.1016/j.jbiotec.2013.07.006

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Stable hybridoma cultivation in a pilot-scale acoustic perfusion system: long-term process performance and effect of recirculation rate

Autor: Marcella C.F. Dalm, Johannes Tramper, Timo Keijzer, Wout M.J. van Grunsven, Menno Jansen, Dirk E. Martens, Arthur Oudshoorn

Publikováno v: Biotechnology and Bioengineering, 91(7), 894-900
Biotechnology and Bioengineering 91 (2005) 7

Perfusion systems have the possibility to be operated continuously for several months. It is important that the performance of the cell retention device does not limit the operation time of a perfusion process used in the production of active pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6e1e8be580689b553e6049d8cfc512
https://doi.org/10.1002/bit.20552

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Biosynthesis of Germacrene A Carboxylic Acid in Chicory Roots. Demonstration of a Cytochrome P450 (+)-Germacrene A Hydroxylase and NADP+-Dependent Sesquiterpenoid Dehydrogenase(s) Involved in Sesquiterpene Lactone Biosynthesis

Autor: Jan-Willem de Kraker, Aede de Groot, Harro J. Bouwmeester, Marcella C.F. Dalm, Maurice C. R. Franssen

Publikováno v: Plant Physiology, 121(4), 1930-1940
Plant Physiology 121 (2001) 4

Sprouts of chicory (Cichorium intybus), a vegetable grown in the dark, have a slightly bitter taste associated with the presence of guaianolides, eudesmanolides, and germacranolides. The committed step in the biosynthesis of these compounds is cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb87afe331c7e84a69fce13749a3533
https://doi.org/10.1104/pp.125.4.1930

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Integrated bioproduction and extraction of 3-methylcatechol

Autor: Rik Beeftink, Jan Wery, Leonie E. Hüsken, Marcella C.F. Dalm, Johannes Tramper, Jan A.M. de Bont

Publikováno v: Journal of Biotechnology 88 (2001)
Journal of Biotechnology, 88, 11-19

Pseudomonas putida MC2 is a solvent-tolerant strain that accumulates 3-methylcatechol. In aqueous media, 10 mM of 3-methylcatechol was produced and production was limited by 3-methylcatechol toxicity to the biocatalyst. Production levels increased by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c779ef187965b1ea572288e2a5671c8
https://doi.org/10.1016/s0168-1656(01)00252-8

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[Untitled]

Autor: Andrew J. Daugulis, Sung-Ho Yeom, Marcella C.F. Dalm

Publikováno v: Biotechnology Letters. 22:1747-1751

A continuous treatment system combining a packed-bed column and a two-phase partitioning bioreactor has been designed to treat high-concentration benzene-containing gas streams. 1-Octadecene was used in a closed loop as an absorbant to scrub benzene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84c5e7cc07cfcbb2bc66da52ce5c9a8c
https://doi.org/10.1023/a:1005689917744

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Effect of feed and bleed rate on hybridoma cells in an acoustic perfusion bioreactor: metabolic analysis

Autor: Wout M.J. van Grunsven, Johannes Tramper, Suzanne M. R. Cuijten, Anne-Marie Tjeerdsma, Packo P. Lamers, Marcella C.F. Dalm, Dirk E. Martens

Publikováno v: Biotechnology Progress, 23(3), 560-569
Biotechnology Progress 23 (2007) 3

For the development of optimal perfusion processes, insight into the effect of feed and bleed rate on cell growth, productivity, and metabolism is essential. In the here presented study the effect of the feed and bleed rate on cell metabolism was inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18fd0f4e680942f8d2ee83226baf478
https://pubmed.ncbi.nlm.nih.gov/17439155

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Effect of feed and bleed rate on hybridoma cells in an acoustic perfusion bioreactor: part I. Cell density, viability, and cell-cycle distribution

Autor: Johannes Tramper, Suzanne M. R. Cuijten, Marcella C.F. Dalm, Wout M.J. van Grunsven, Dirk E. Martens

Publikováno v: Biotechnology and bioengineering. 88(5)

For the development of optimal perfusion processes the effect of the feed and bleed rate on cell growth in a perfusion bioreactor was studied. The viable-cell density, viability, growth, death, and lysis rate and cell-cycle distribution of a hybridom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f94aa94a3bdc02cf453abef4fe9bd4
https://pubmed.ncbi.nlm.nih.gov/15459904

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