Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Marcell Krekó"'
Autor:
Péter Kisfaludi, Sára Spátay, Marcell Krekó, Panna Vezse, Tünde Tóth, Péter Huszthy, Ádám Golcs
Publikováno v:
Molecules, Vol 29, Iss 18, p 4390 (2024)
Oligoamines in cellular metabolism carry extremely diverse biological functions (i.e., regulating Ca2+-influx, neuronal nitric oxide synthase, membrane potential, Na+, K+-ATPase activity in synaptosomes, etc.). Furthermore, they also act as longevity
Externí odkaz:
https://doaj.org/article/73bd90842d9240e78b3a4758e680bce2
Autor:
János Garai, Marcell Krekó, László Őrfi, Péter Balázs Jakus, Zoltán Rumbus, Patrik Kéringer, András Garami, Eszter Vámos, Dominika Kovács, Viola Bagóné Vántus, Balázs Radnai, Tamás Lóránd
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1356-1368 (2021)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts a unique tautomerase enzymatic activity that has relevance concerning its multiple functions and its small molecule inhibitors ha
Externí odkaz:
https://doaj.org/article/99c9586e388a44fd96582e44a894d6e8
Autor:
János Garai, Balázs Radnai, Eszter Vámos, Dominika Kovács, Viola Bagóné Vántus, Zoltán Rumbus, Eszter Pákai, András Garami, Gergely Gulyás-Fekete, Attila Agócs, Marcell Krekó, Khadiza Zaman, László Prókai, László Őrfi, Péter B. Jakus, Tamás Lóránd
Publikováno v:
European Journal of Medicinal Chemistry. 247:115050
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with enzymatic activities. Anti-inflammatory effects of MIF enzyme inhibitors indicate a link between its cytokine- and catalytic activities. Herein the synthesis, docking, an
Autor:
Sándor Boros, Marcell Krekó, Péter Markó, László Őrfi, Eszter Illyés, Péter Bánhegyi, Bálint Szokol, István Szabadkai, Zsófia Czudor, Csaba Szántai-Kis, Diána Brauswetter, Pál Gyulavári, Attila Varga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3265-3270
Aurora kinases as regulators of cell division have become promising therapeutic targets recently. Here we report novel, low molecular weight benzothiophene-3-carboxamide derivatives designed and optimized for inhibiting Aurora kinases. The most effec
Autor:
Mihály Cserepes, Csaba Szántai-Kis, Eszter Szabó, Zoltán Őrfi, Judit Dobos, László Őrfi, Rita Garamvölgyi, Marcell Krekó, Ferenc Baska, József Tóvári, László Dézsi, Gábor Szénási, Zoltán Nemes, Péter Hamar, Anna Sipos
Publikováno v:
European journal of medicinal chemistry. 184
Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20–30% of patients. In this study we identified a highly selective (phenylethenyl)quinazoline compound family as