Výsledky vyhledávání - "Marceline Huppmann"

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

Autor: Joseph Rosenecker, Michael S. D. Kormann, Matthias Griese, Manish K. Aneja, Andreas W. Flemmer, Gabriela Nica, Lauren Mays, Dominik Hartl, Andrea Schams, Günther Hasenpusch, Iris Bittmann, Marceline Huppmann, Marta C Illenyi, Rupert Handgretinger, Carsten Rudolph, Susanne Herber-Jonat

Publikováno v: Nature Biotechnology. 29:154-157

Current viral vectors for gene therapy are associated with serious safety concerns, including leukemogenesis, and nonviral vectors are limited by low gene transfer efficiency. Here we investigate the therapeutic utility of chemically modified mRNA as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514ecee682bbc6e6753bb1e9009648e6
https://doi.org/10.1038/nbt.1733

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Abca3 haploinsufficiency is a risk factor for lung injury induced by hyperoxia or mechanical ventilation in a murine model

Autor: Martin Hrabé de Angelis, M Hammel, S Herber-Jonat, Andreas W. Flemmer, Oliver Eickelberg, Rashmi Mittal, Gerhard Liebisch, Andreas Holzinger, Marceline Huppmann, Gerd Schmitz, Aö Yildirim

Publikováno v: Pediatr. Res. 74, 384-392 (2013)

Background:Heterozygous ABCA3 (ATP-binding-cassette sub-family A member3) mutations are associated with neonatal respiratory complications. We investigated in an adult murine model whether Abca3 haploinsufficiency is a predisposing factor for lung in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7575d920a7b86a150dd552e7857e05a8
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=27236

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Neonatal Bacille Calmette-Guerin vaccination and type 1 diabetes

Autor: Marceline Huppmann, Andrea Baumgarten, Anette-G. Ziegler, Ezio Bonifacio

Publikováno v: Diabetes care. 28(5)

Type 1 diabetes is a genetic disorder that is associated with the early development of autoimmunity against islet β-cells (1). The a priori genetically determined risk for type 1 diabetes is modified by mostly unknown environmental factors that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7165a2b999d293518c6e25586b3153c4
https://pubmed.ncbi.nlm.nih.gov/15855590

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