A novel 1-((3-(2-toluyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-(trifluoromethyl)pyrimidin-2(1H)-one activates intrinsic mitochondria-dependent pathway and decreases angiogenesis in PC-3 cells

Autor: Marcela Silva dos Santos, Simone Schneider Amaral, Cassiana Macagnan Viau, Marcio M. Lobo, Jenifer Saffi, Nilo Zanatta

Publikováno v: European journal of pharmacology. 899

Prostate cancer is among the most common cancer diagnoses in men, and the best treatment for patients with metastatic disease in advanced stages is still unclear. Previously, we have demonstrated that the three 1-(3-(aryl-4,5-dihydroisoxazol-5-yl)met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4d941e12fdef88d4d2f209e755a0ac
https://pubmed.ncbi.nlm.nih.gov/33727055

Biotoxicological Analyses of Trimeroside from Baccharis trimera Using a Battery of In Vitro Test Systems

Autor: Cleverson Costa Feistel, Indara Dedigo de Almeida, Alexandre de Barros Falcão Ferraz, Lismare da Silva Prado, Marcela Silva dos Santos, Ivana Grivicich, Juliana da Silva, Jaqueline Nascimento Picada, Francisco Maikon Corrêa de Barros, Maria Luísa Brodt Lemes, Raíssa Rebés Rossatto, Ana Paula Simões Menezes

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)

The use in folk medicine of Baccharis trimera and recent studies on DNA damage by oxidative stress mechanisms have motivated this study. We investigated the biotoxicological effects of trimeroside from this plant. Aqueous extract from aerial parts of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13502ebe3d8fffde16407ecb65e0128
https://doaj.org/article/7f53750c8c114da1b41df507c282a29e

Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study

Autor: Enrique Vazquez, Romildo Siqueira de Assunção, Patrícia Ismael de Carvalho, Sandra Valongueiro, Carmen Dhalia, Pilar Ramon-Pardo, Juan José Cortez-Escalante, Thália Velho Barreto de Araújo, Cláudio Maierovitch Pessanha Henriques, Leuridan Torres, Laura C. Rodrigues, Marli Tenório Cordeiro, Cynthia Braga, Jairo Mendez-Rico, Sinval Pinto Brandão Filho, Wanderson Kleber de Oliveira, Demócrito de Barros Miranda-Filho, Fanny Cortes, Rafael Dhalia, Sylvain Aldighieri, Carlos A. Melo, Ernesto Torres Azevedo Marques-Júnior, Celina Maria Turchi Martelli, Marcela Silva dos Santos, George Santiago Dimech, Ana Paula Lopes de Melo, Danielle Di Cavalcanti Souza Cruz, Wayner Vieira de Souza, Ana van der Linden, Priscila M. S. Castanha, Valdete Felix de Oliveira, Monica Coentro, Giovanini E. Coelho, Ricardo Arraes de Alencar Ximenes, Luciana Caroline Albuquerque Bezerra, Maria de Fátima Pessoa Militão de Albuquerque, Ulisses Ramos Montarroyos, Marcos A. Espinal, Adriano Nassri Hazin

Publikováno v: The Lancet Infectious Diseases

Summary Background A Zika virus epidemic emerged in northeast Brazil in 2015 and was followed by a striking increase in congenital microcephaly cases, triggering a declaration of an international public health emergency. This is the final report of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628ae33a948c747541d68a4b9dcd9a9f
https://pubmed.ncbi.nlm.nih.gov/29307514

Evaluation of Toxicological Effects of an Aqueous Extract of Shells from the Pecan Nut Carya illinoinensis (Wangenh.) K. Koch and the Possible Association with Its Inorganic Constituents and Major Phenolic Compounds

Autor: Alexandre de Barros Falcão Ferraz, Luiz Carlos Santos Porto, Juliana da Silva, Aline Vanessa de Almeida, Patrícia Pereira, Mariana Leal Ambrozio, Johnny Ferraz Dias, Mariangela da Costa Allgayer, Karen Sousa, Carla Eliete Iochims dos Santos, Jaqueline Nascimento Picada, Marcela Silva dos Santos

Publikováno v: Evidence-Based Complementary and Alternative Medicine, Vol 2016 (2016)
Evidence-based Complementary and Alternative Medicine : eCAM

Background.Industrial processing of the pecan nutCarya illinoinensisK. Koch generated a large amount of shells, which have been used to prepare nutritional supplements and medicinal products; however, the safe use of shells requires assessment. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97de6ef0f3eed0d4be4885d22e74cc6
https://doaj.org/article/a215b6ed8a694a70a666f7a23c2b08b8

Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch]

Autor: Caroline Dalla Lana Porto, Dione Silva Corrêa, Jaqueline Nascimento Picada, Marcela Silva dos Santos, Alexandre de Barros Falcão Ferraz, Juliana da Silva, Luiz Carlos Santos Porto

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 59

The infusion of pecan shells has been used to prevent and control hypercholesterolemia, diabetes and toxicological diseases. The aim of the present study was to evaluate toxicity and mutagenic effects of pecan shells aqueous extract (PSAE). Wistar ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45eecf8d356595524581524e9c63f8bd
https://pubmed.ncbi.nlm.nih.gov/23831307