Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Marcela Montes de Oca"'
Autor:
Yulin Wang, Fabian De Labastida Rivera, Chelsea L. Edwards, Teija C.M. Frame, Jessica A. Engel, Luzia Bukali, Jinrui Na, Susanna S. Ng, Dillon Corvino, Marcela Montes de Oca, Patrick T. Bunn, Megan S.F. Soon, Dean Andrew, Jessica R. Loughland, Jia Zhang, Fiona H. Amante, Bridget E. Barber, James S. McCarthy, J. Alejandro Lopez, Michelle J. Boyle, Christian R. Engwerda
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
The development of highly effective malaria vaccines and improvement of drug-treatment protocols to boost antiparasitic immunity are critical for malaria elimination. However, the rapid establishment of parasite-specific immune regulatory networks fo
Externí odkaz:
https://doaj.org/article/3c2a3ba4c5594fffbb78ac8fa7298d0d
Autor:
Chelsea L. Edwards, Susanna S. Ng, Fabian de Labastida Rivera, Dillon Corvino, Jessica A. Engel, Marcela Montes de Oca, Luzia Bukali, Teija C.M. Frame, Patrick T. Bunn, Shashi Bhushan Chauhan, Siddharth Sankar Singh, Yulin Wang, Jinrui Na, Fiona H. Amante, Jessica R. Loughland, Megan S.F. Soon, Nicola Waddell, Pamela Mukhopadhay, Lambros T. Koufariotis, Rebecca L. Johnston, Jason S. Lee, Rachel Kuns, Ping Zhang, Michelle J. Boyle, Geoffrey R. Hill, James S. McCarthy, Rajiv Kumar, Christian R. Engwerda
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/1c7a7aac042d489a8d9ce7e4e35f9dc0
Autor:
Marcela Montes de Oca, Fabian de Labastida Rivera, Clay Winterford, Teija C M Frame, Susanna S Ng, Fiona H Amante, Chelsea L Edwards, Luzia Bukali, Yulin Wang, Jude E Uzonna, Rachel D Kuns, Ping Zhang, Agnieszka Kabat, Ramon I Klein Geltink, Edward J Pearce, Geoffrey R Hill, Christian R Engwerda
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008994 (2020)
Inflammation is critical for controlling pathogens, but also responsible for symptoms of infectious diseases. IL-27 is an important regulator of inflammation and can limit development of IFNγ-producing Tbet+ CD4+ T (Th1) cells. IL-27 is thought to d
Externí odkaz:
https://doaj.org/article/d4ce631961bd4ced87a72fbb062a5bf9
Autor:
Rajiv Kumar, Patrick T. Bunn, Siddharth Sankar Singh, Susanna S. Ng, Marcela Montes de Oca, Fabian De Labastida Rivera, Shashi Bhushan Chauhan, Neetu Singh, Rebecca J. Faleiro, Chelsea L. Edwards, Teija C.M. Frame, Meru Sheel, Rebecca J. Austin, Steven W. Lane, Tobias Bald, Mark J. Smyth, Geoffrey.R. Hill, Shannon E. Best, Ashraful Haque, Dillon Corvino, Nic Waddell, Lambross Koufariotis, Pamela Mukhopadhay, Madhukar Rai, Jaya Chakravarty, Om Prakash Singh, David Sacks, Susanne Nylen, Jude Uzonna, Shyam Sundar, Christian R. Engwerda
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2512-2525.e9 (2020)
Summary: Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T ce
Externí odkaz:
https://doaj.org/article/e785a439bde64e73885e903f52fe0682
Autor:
Jessica R. Loughland, Gabriela Minigo, Derek S. Sarovich, Matt Field, Peta E. Tipping, Marcela Montes de Oca, Kim A. Piera, Fiona H. Amante, Bridget E. Barber, Matthew J. Grigg, Timothy William, Michael F. Good, Denise L. Doolan, Christian R. Engwerda, Nicholas M. Anstey, James S. McCarthy, Tonia Woodberry
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Plasmacytoid dendritic cells (pDC) are activators of innate and adaptive immune responses that express HLA-DR, toll-like receptor (TLR) 7, TLR9 and produce type I interferons. The role of human pDC in malaria remains poorly characterised. pD
Externí odkaz:
https://doaj.org/article/7fc57d1115ad4d4da48e9b4697978c9e
Autor:
Marcela Montes de Oca, Rajiv Kumar, Fabian de Labastida Rivera, Fiona H. Amante, Meru Sheel, Rebecca J. Faleiro, Patrick T. Bunn, Shannon E. Best, Lynette Beattie, Susanna S. Ng, Chelsea L. Edwards, Glen M. Boyle, Ric N. Price, Nicholas M. Anstey, Jessica R. Loughland, Julie Burel, Denise L. Doolan, Ashraful Haque, James S. McCarthy, Christian R. Engwerda
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 399-412 (2016)
The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-
Externí odkaz:
https://doaj.org/article/9b05fd1ed67d459e9852bf440f0c5250
Autor:
Chelsea L. Edwards, Marcela Montes de Oca, Fabian de Labastida Rivera, Rajiv Kumar, Susanna S. Ng, Yulin Wang, Fiona H. Amante, Kohei Kometani, Tomohiro Kurosaki, Tom Sidwell, Axel Kallies, Christian R. Engwerda
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) is a transcription factor best known for its role in B cell development. More recently, it has been associated with T cell functions in inflammatory diseases, and has been pr
Externí odkaz:
https://doaj.org/article/1f25a2a7595f4585b07b3ed643da741f
Autor:
Ramon M. Eichenberger, Stephanie Ryan, Linda Jones, Geraldine Buitrago, Ramona Polster, Marcela Montes de Oca, Jennifer Zuvelek, Paul R. Giacomin, Lindsay A. Dent, Christian R. Engwerda, Matthew A. Field, Javier Sotillo, Alex Loukas
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm to their hosts, allowing them to establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, hookworms are such poten
Externí odkaz:
https://doaj.org/article/9f3c10655abd46c582652783db9407dc
Autor:
Patrick T. Bunn, Marcela Montes de Oca, Fabian de Labastida Rivera, Rajiv Kumar, Chelsea L. Edwards, Rebecca J. Faleiro, Susanna S. Ng, Meru Sheel, Yulin Wang, Fiona H. Amante, Ashraful Haque, Christian R. Engwerda
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Many infectious diseases are characterized by the development of immunoregulatory pathways that contribute to pathogen persistence and associated disease symptoms. In diseases caused by intracellular parasites, such as visceral leishmaniasis (VL), va
Externí odkaz:
https://doaj.org/article/90b714a06a994e9780cda45e80e88b05
Autor:
Ismail Sebina, Kylie R James, Megan S F Soon, Lily G Fogg, Shannon E Best, Fabian de Labastida Rivera, Marcela Montes de Oca, Fiona H Amante, Bryce S Thomas, Lynette Beattie, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth, Paul J Hertzog, Geoffrey R Hill, Andreas Hutloff, Christian R Engwerda, Ashraful Haque
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005999 (2016)
Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many months for naturally-exposed individuals to develop robust humoral immunity. Explanations for this have focused on antig
Externí odkaz:
https://doaj.org/article/a54be06609244dfbb023d5a998aed957