Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marcela Guzman-Ayala"'
Autor:
Aydan Bulut-Karslioglu, Hu Jin, Yun-Kyo Kim, Brandon Cho, Marcela Guzman-Ayala, Andrew J. K. Williamson, Miroslav Hejna, Maximilian Stötzel, Anthony D. Whetton, Jun S. Song, Miguel Ramalho-Santos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal
Externí odkaz:
https://doaj.org/article/362975551fcb4640be6efa18d7a17af1
Autor:
Nicholas Redshaw, Carme Camps, Vikas Sharma, Mehdi Motallebipour, Marcela Guzman-Ayala, Spyros Oikonomopoulos, Efstathia Thymiakou, Jiannis Ragoussis, Vasso Episkopou
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55186 (2013)
The Transforming Growth Factor-β (TGF-β) signaling pathway is one of the major pathways essential for normal embryonic development and tissue homeostasis, with anti-tumor but also pro-metastatic properties in cancer. This pathway directly regulates
Externí odkaz:
https://doaj.org/article/0a2eba45ff01472ab54a4c533d4d69f3
Autor:
Marcela Guzman-Ayala, Kian Leong Lee, Konstantinos J. Mavrakis, Paraskevi Goggolidou, Dominic P. Norris, Vasso Episkopou
Publikováno v:
PLoS ONE, Vol 4, Iss 2 (2009)
Externí odkaz:
https://doaj.org/article/f119bffcf56247a1b7e802818ba64e60
Autor:
Marcela Guzman-Ayala, Kian Leong Lee, Konstantinos J Mavrakis, Paraskevi Goggolidou, Dominic P Norris, Vasso Episkopou
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4268 (2009)
The Transforming Growth Factor (TGF) beta signalling family includes morphogens, such as Nodal and Activin, with important functions in vertebrate development. The concentration of the morphogen is critical for fate decisions in the responding cells.
Externí odkaz:
https://doaj.org/article/5a1a3f9b0cd84630b10f4de01fd340e2
Autor:
Marcela Guzman Ayala, Michelle Hung, Deepika Kaveri, Rebecca Cottman, Elizabeth Leitner, Priscilla Wong, Ronni Ponek, Enping Hong, Manan Shah, Andrew Banicki, Lawrence Naitmazi, Kelly Lee, Wesley Gorman, Russell Gordley, Philip Lee, Timothy Lu
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::371a72e83b8e900102e21abe6f3cae31
https://doi.org/10.1136/jitc-2022-sitc2022.0228
https://doi.org/10.1136/jitc-2022-sitc2022.0228
Autor:
Travis Wood, Brian S. Garrison, Han Deng, Nicholas W. Frankel, Wesley Gorman, Alice Lam, Tiffany Pan, Timothy K. Lu, Russell Morrison Gordley, Derrick G. Lee, Jenny Chien, Kathryn A. Loving, Gozde Yucel, Nelia Leemans, Marcela Guzman-Ayala, Gary Lee, Marcus Gainer, Wilson W. Wong, Philip I. Lee, Michelle Elizabeth Hung
Publikováno v:
Blood. 138:2799-2799
Background: While chimeric antigen receptor (CAR) cell therapies have provided extraordinary clinical responses in some hematological malignancies, developing effective CAR cell therapies for acute myeloid leukemia (AML) has been challenging due to:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb18f48ad64ed50905e35eec6c2671ab
https://doi.org/10.1182/blood-2021-154201
https://doi.org/10.1182/blood-2021-154201
Autor:
Anthony D. Whetton, Miroslav Hejna, Jun S. Song, Andrew J.K. Williamson, Marcela Guzman-Ayala, Aydan Bulut-Karslioglu, Miguel Ramalho-Santos, Hu Jin
Stem and progenitor cells undergo a global elevation of nascent transcription, or hypertranscription, during key developmental transitions involving rapid cell proliferation. The chromatin remodeler Chd1 binds to genes transcribed by RNA Polymerase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9ba5d323536c4f87977f7b14d4090c
Autor:
Marcela Guzman-Ayala, Aydan Bulut-Karslioglu, Courtney Onodera, Priscilla Wong, Michael Sachs, Chih-Jen Lin, Miguel Ramalho-Santos, Rachel Nitta, Fong Ming Koh, Jun S. Song
Publikováno v:
Development. 142:118-127
The pluripotent mammalian epiblast undergoes unusually fast cell proliferation. This rapid growth is expected to generate a high transcriptional demand, but the underlying mechanisms remain unknown. We show here that the chromatin remodeler Chd1 is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4697ed024a12804da6fd381ed36aa05c
https://doi.org/10.1242/dev.114843
https://doi.org/10.1242/dev.114843
Publikováno v:
Current Opinion in Genetics & Development. 20:492-499
Open chromatin is a hallmark of pluripotent stem cells, but the underlying molecular mechanisms are only beginning to be unraveled. In this review we highlight recent studies that employ embryonic stem cells and induced pluripotent stem cells to inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f0c421fef80aac83bbafa6114393c4
https://doi.org/10.1016/j.gde.2010.06.002
https://doi.org/10.1016/j.gde.2010.06.002
Autor:
Daniel Mesnard, Luca Pescatore, Nadav Ben-Haim, Cindy C. Lu, Daniel B. Constam, Elizabeth J. Robertson, Felix Naef, Mirko Bischofberger, Marcela Guzman-Ayala
Publikováno v:
Developmental Cell. 11(3):313-323
During early mouse development, the subtilisin-like proprotein convertases (SPC) Furin and PACE4 pattern the primitive ectoderm and visceral endoderm, presumably by activating the TGFss-related Nodal precursor. Here, mutation of the SPC motif provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eaebf9c77bd037b2646c393b14a92b