Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Marcela González Cid"'
Publikováno v:
Chromosome Research. 30:459-476
ATM and DNA-PKcs coordinate the DNA damage response at multiple levels following the exposure to chemotherapy. The Topoisomerase II poison etoposide (ETO) is an effective chemotherapeutic agent that induces DNA double-strand breaks (DSB), but it is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7e5414cd53cc444e56c38f5eecc99e
https://doi.org/10.1007/s10577-022-09700-w
https://doi.org/10.1007/s10577-022-09700-w
Autor:
Lucia Zavala, Josefina Perez Maturo, Marcela González Cid, Sergio Alejandro Rodríguez Quiroga, Marcelo Andrés Kauffman
Publikováno v:
Movement Disorders Clinical Practice. 7:727-729
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae058c3203f853e665971adb95c26c2f
https://doi.org/10.1002/mdc3.13013
https://doi.org/10.1002/mdc3.13013
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12489 (2010)
Topoisomerase II (Top2) is a nuclear enzyme involved in several metabolic processes of DNA. Chemotherapy agents that poison Top2 are known to induce persistent protein-mediated DNA double strand breaks (DSB). In this report, by using knock down exper
Externí odkaz:
https://doaj.org/article/fb5a48d8eca540629db097f43f0213b2
Autor:
Carmen Stanganelli, Irma Slavutsky, Andrea Krzywinski, Micaela Palmitelli, Marcela González Cid, Flavia Stella, Raimundo F. Bezares
Genomic instability is a hallmark of cancer, contributing to tumour development and transformation, being chromosome instability (CIN) the most common form in human cancer. Chronic lymphocytic leukaemia (CLL) is the most frequent adult leukaemia in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d50034e3a9a24d74957aad0fb847c1a
https://academic.oup.com/mutage/article-abstract/34/3/245/5481700?redirectedFrom=fulltext
https://academic.oup.com/mutage/article-abstract/34/3/245/5481700?redirectedFrom=fulltext
Publikováno v:
Cytometry Part A. 89:852-860
Topoisomerase II (Top2) is an important target for anticancer therapy. A variety of drugs that poison Top2, including several epipodophyllotoxins, anthracyclines, and anthracenediones, are widely used in the clinic for both hematologic and solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694fe3c1b7ab79ab91a396ccb07940c4
https://doi.org/10.1002/cyto.a.22919
https://doi.org/10.1002/cyto.a.22919
Publikováno v:
Current Protocols in Cytometry
The poisoning of Topoisomerase II (Top2) has been found to be useful as a therapeutic strategy for the treatment of several tumors. The mechanisms of these agents involves a drug-mediated stabilization of a Top2-DNA complex, termed Top2 cleavage comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1918c01c8d865d490f3d9e9ee498a18a
https://pubmed.ncbi.nlm.nih.gov/28678420
https://pubmed.ncbi.nlm.nih.gov/28678420
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 89(9)
Topoisomerase II (Top2) is an important target for anticancer therapy. A variety of drugs that poison Top2, including several epipodophyllotoxins, anthracyclines, and anthracenediones, are widely used in the clinic for both hematologic and solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d12453bf47bbdfc5bfda7a237f40107
https://pubmed.ncbi.nlm.nih.gov/27517472
https://pubmed.ncbi.nlm.nih.gov/27517472
Autor:
Jose Maria Raviolo, Hugo García Ovando, Marcela González Cid, Fernando Mañas, A. Weyers, Laura Peralta, L. Ugnia, Irene Larripa, Nora Gorla
Publikováno v:
Environmental Toxicology and Pharmacology. 28:37-41
It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42 ± 1.83 arbitrary units) for tail moment (TM) measurements has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4025bebec62c8a5f6a7b083ed0adbb
https://doi.org/10.1016/j.etap.2009.02.001
https://doi.org/10.1016/j.etap.2009.02.001
Autor:
Abel L. Carcagno, Omar Pedro Pignataro, Eduardo T. Cánepa, Marcela González-Cid, María Elida Scassa, Pablo Federico Sirkin, Julieta M. Ceruti, Mariela C. Marazita
Publikováno v:
DNA Repair. 6:626-638
Genome integrity and cell proliferation and survival are regulated by an intricate network of pathways that includes cell cycle checkpoints, DNA repair and recombination, and programmed cell death. It makes sense that there should be a coordinated re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5d1a83378f1bf1a6ce2aa4160c1805
https://doi.org/10.1016/j.dnarep.2006.12.003
https://doi.org/10.1016/j.dnarep.2006.12.003
Etoposide (ETO), a drug used for the treatment of human tumors, is associated with the development of secondary malignancies. Recently, therapeutic strategies have incorporated chemosensitizing agents to improve the tumoral response to this drug. ETO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157686f759b1bf9022ae693bb2553e76
https://link.springer.com/article/10.1007/s10577-015-9478-4
https://link.springer.com/article/10.1007/s10577-015-9478-4