Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marcela Doktorova"'
Autor:
Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J.C. Bijvelds
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)
Background & Aims: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbios
Externí odkaz:
https://doaj.org/article/0a415309b75c4917861654a9a812df3d
Autor:
Marcela Doktorova, Irene Zwarts, Tim van Zutphen, Theo H. van Dijk, Vincent W. Bloks, Liesbeth Harkema, Alain de Bruin, Michael Downes, Ronald M. Evans, Henkjan J. Verkade, Johan W. Jonker
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Peroxisome proliferator-activated receptor δ (PPARδ) is a ligand-activated transcription factor that has an important role in lipid metabolism. Activation of PPARδ stimulates fatty acid oxidation in adipose tissue and skeletal muscle and
Externí odkaz:
https://doaj.org/article/adc9aeb287f8410a912102df98040a2d
Publikováno v:
Respiratory Medicine Case Reports, Vol 28, Iss , Pp - (2019)
The present case demonstrates an atypical pulmonary mycobacteriosis that mimicked classical symptoms and radiology findings for tuberculosis. While T-SPOT Test and PCR analyses proved negative for tuberculosis, microscopic sputum evaluation showed ac
Externí odkaz:
https://doaj.org/article/dc5a87a519554b4eaffced7d94dbf30f
Autor:
Hugo R. de Jonge, Kelly F. Meijsen, Johan W. Jonker, Pauline T. Ikpa, Marcel J. C. Bijvelds, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Marcela Doktorova
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)
Cellular and molecular gastroenterology and hepatology, 9(1), 47-60. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 9(1), 47-60. Elsevier Inc.
Cellular and molecular gastroenterology and hepatology, 9(1), 47-60. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 9(1), 47-60. Elsevier Inc.
Background & Aims The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbiosi
Autor:
Henkjan J. Verkade, Marcela Doktorova-Demmin, Johan W. Jonker, Ivo P van de Peppel, Frank A J A Bodewes, Hugo R. de Jonge, Anna Bertolini, Marcel J. C. Bijvelds
Publikováno v:
American Journal of Physiology. Gastrointestinal and Liver Physiology, 316(3), G404-G411. AMER PHYSIOLOGICAL SOC
American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(3), G404-G411. American Physiological Society
American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(3), G404-G411. American Physiological Society
The gastrointestinal phenotype of cystic fibrosis (CF) features intestinal bile acid (BA) malabsorption, impaired intestinal farnesoid X receptor (FXR) activation, and consequently reduced fibroblast growth factor 19 (FGF19, FGF15 in mice) production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f9a38663e7a6128d8e67553c52564c
https://research.rug.nl/en/publications/e446459d-2599-4ab6-b324-4cb053103c23
https://research.rug.nl/en/publications/e446459d-2599-4ab6-b324-4cb053103c23
Autor:
Hugo R. de Jonge, Johan W. Jonker, Roderick H. J. Houwen, Marcela Doktorova, Gitte Berkers, Henkjan J. Verkade, Frank A J A Bodewes, Ivo P van de Peppel
Publikováno v:
Journal of Cystic Fibrosis, 18(2), 286-293. ELSEVIER SCIENCE BV
Journal of Cystic Fibrosis, 18(2), 286-293. Elsevier
Journal of Cystic Fibrosis, 18(2), 286. Elsevier
Journal of Cystic Fibrosis, 18(2), 286-293. Elsevier
Journal of Cystic Fibrosis, 18(2), 286. Elsevier
Objective: Disruption of the enterohepatic circulation of bile acids (BAs) is part of the gastrointestinal phenotype of cystic fibrosis (CF). Ivacaftor (VX-770), a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, improves pulmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cd702462ac142ce271379e72e69cfe
https://research.rug.nl/en/publications/1474aa8c-54a0-4a91-a372-1e2ce262adff
https://research.rug.nl/en/publications/1474aa8c-54a0-4a91-a372-1e2ce262adff
Autor:
Henkjan J. Verkade, Mariette Y. M. van der Wulp, Satti Beharry, M. James Phillips, Renze Boverhof, Rick Havinga, Peter R. Durie, Frank A J A Bodewes, Marcela Doktorova
Publikováno v:
Journal of Cystic Fibrosis, 14(4), 440-446. ELSEVIER SCIENCE BV
Background: Cftr(-/-tm1UC) mice develop progressive hepato-biliary pathology. We hypothesize that this liver pathology is related to alterations' in biliary bile hydrophobicity and bile salt metabolism in Cftr(-/-tm1Unc) mice.Methods: We determined b
Autor:
Vinay Sachdev, Christina Leopold, Raimund Bauer, Jay V. Patankar, Jahangir Iqbal, Sasha Obrowsky, Renze Boverhof, Marcela Doktorova, Bernhard Scheicher, Dagmar Kolb, Andrew V. Turnbull, Andreas Zimmer, Gerald Hoefler, Mahmood M. Hussain, Albert K. Groen, Dagmar Kratky
Publikováno v:
ATHEROSCLEROSIS, 275, E10-E11. ELSEVIER IRELAND LTD
Publikováno v:
Respiratory Medicine Case Reports, Vol 28, Iss, Pp-(2019)
Respiratory Medicine Case Reports
Respiratory Medicine Case Reports
The present case demonstrates an atypical pulmonary mycobacteriosis that mimicked classical symptoms and radiology findings for tuberculosis. While T-SPOT Test and PCR analyses proved negative for tuberculosis, microscopic sputum evaluation showed ac
Autor:
Vinay, Sachdev, Christina, Leopold, Raimund, Bauer, Jay V, Patankar, Jahangir, Iqbal, Sascha, Obrowsky, Renze, Boverhof, Marcela, Doktorova, Bernhard, Scheicher, Madeleine, Goeritzer, Dagmar, Kolb, Andrew V, Turnbull, Andreas, Zimmer, Gerald, Hoefler, M Mahmood, Hussain, Albert K, Groen, Dagmar, Kratky
Publikováno v:
Biochimica et biophysica acta
Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and pharmacological inhibition of DGAT1 in mice alters cholesterol metabolism. Cholesterol absorption, as ass