TLR3 is required for survival following Coxsackievirus B3 infection by driving T lymphocyte activation and polarization: The role of dendritic cells.

Autor: Renata Sesti-Costa, Marcela Cristina Santiago Françozo, Grace Kelly Silva, José Luiz Proenca-Modena, João Santana Silva

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185819 (2017)

Type B coxsackievirus (CVB) is a common cause of acute and chronic myocarditis, meningitis and pancreatitis, often leading to heart failure and pancreatic deficiency. The polarization of CD4+ T lymphocytes and their cytokine milieu are key factors in

Externí odkaz: https://doaj.org/article/b3b15bedf227493aa4397fcb30f22cf6

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

Autor: Noah W. Palm, Daniela Carlos, Dario S. Zamboni, Marcel R. de Zoete, Richard A. Flavell, Niels Olsen Saraiva Câmara, Aline Ignacio, Frederico R. C. Costa, Angela Castoldi, Marcela Cristina Santiago Françozo, Simone G. Ramos, Gabriela Gonçalves de Oliveira, João Santana da Silva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of Experimental Medicine, 213(7), 1223. Rockefeller University Press
The Journal of Experimental Medicine

Streptozotocin causes T1D by inducing the translocation of intestinal bacteria into pancreatic lymph nodes and driving the development of pathogenic Th1 and Th17 cells through NOD2 receptor.
Type 1 diabetes (T1D) is an autoimmune disease that is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4867bf3e6bf47fd99df27fb8d7398634