Chemokine-like receptor 1 deficiency does not affect the development of insulin resistance and nonalcoholic fatty liver disease in mice.

Autor: Nanda Gruben, Marcela Aparicio Vergara, Niels J Kloosterhuis, Henk van der Molen, Stefan Stoelwinder, Sameh Youssef, Alain de Bruin, Dianne J Delsing, Jan Albert Kuivenhoven, Bart van de Sluis, Marten H Hofker, Debby P Y Koonen

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e96345 (2014)

The adipokine chemerin and its receptor, chemokine-like receptor 1 (Cmklr1), are associated with insulin resistance and nonalcoholic fatty liver disease (NAFLD), which covers a broad spectrum of liver diseases, ranging from simple steatosis to nonalc

Externí odkaz: https://doaj.org/article/9382eecd5fa54b4abd033bb97d14caf7

Safety assessment of rhamnogalacturonan-enriched carrot pectin fraction: 90-Day oral toxicity study in rats and in vitro genotoxicity studies

Autor: Ruud Albers, Karin H. van het Hof, Marcela Aparicio-Vergara, Tzoumaki Maria, Paul Fowler, Diana Jonker

Publikováno v: Food and Chemical Toxicology

The dietary fibre product examined is a pectic polysaccharide extract from carrot (Daucus carota), enriched for pectin fragments comprising mainly rhamnogalacturonan-I (RG-I) (abbreviated product name cRG-I). To assess the safety of cRG-I for use as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48079ac39e6db2c81c6cfab9a60f3a1
https://pubmed.ncbi.nlm.nih.gov/32151604

Liver innate immune cells and insulin resistance: the multiple facets of Kupffer cells

Autor: Myriam Aouadi, Marcela Aparicio-Vergara, Jennifer Jager

Publikováno v: Journal of Internal Medicine. 280:209-220

Obesity, which affects 600 million adults worldwide, is a major risk factor for type 2 diabetes (T2D) and insulin resistance. Current therapies for these metabolic disorders include weight management by lifestyle intervention or bariatric surgery and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07bdf587547a3f3a21e93cf498d0fea
https://doi.org/10.1111/joim.12483

Isolation of Kupffer Cells and Hepatocytes from a Single Mouse Liver

Autor: Cecilia Morgantini, Marcela Aparicio-Vergara, Myriam Aouadi, Michaela Tencerova, Emelie Barreby

Publikováno v: Methods in Molecular Biology ISBN: 9781493971619
Aparicio-Vergara, M, Tencerova, M, Morgantini, C, Barreby, E & Aouadi, M 2017, Isolation of Kupffer Cells and Hepatocytes from a Single Mouse Liver . in F Borel & C Mueller (eds), Alpha-1 Antitrypsin Deficiency : Methods and Protocols . vol. 1639, Humana Press, Methods in Molecular Biology, vol. 1639, pp. 161-171 . https://doi.org/10.1007/978-1-4939-7163-3_16

Liver perfusion is a common technique used to isolate parenchymal and non-parenchymal liver cells for in vitro experiments. This method allows hepatic cells to be separated based on their size and weight, by centrifugation using a density gradient. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea157ef031c28e29fc9b88ff6ac9673
https://doi.org/10.1007/978-1-4939-7163-3_16

Bone marrow transplantation in mice as a tool for studying the role of hematopoietic cells in metabolic and cardiovascular diseases

Autor: Marten H. Hofker, Ronit Shiri-Sverdlov, Marcela Aparicio-Vergara, Gerald de Haan

Publikováno v: Atherosclerosis, 213(2), 335-344. Elsevier Ireland Ltd

Hematopoietic cells have been established as major players in cardiovascular disease, with an important role in the etiology of atherosclerotic plaque. In addition, hematopoietic cells, and in particular the cells of monocyte and macrophage lineages,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3183c5a47853de5894bfb0aa4909da71
https://cris.maastrichtuniversity.nl/en/publications/199021e8-39de-486e-b46c-e092152f8dc4