Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marcel de Zwart"'
Publikováno v:
Bioanalysis. 11(19)
Aim: A sensitive method to quantify nafithromycin and its N-desmethyl metabolite in human plasma was necessary for Phase I pharmacokinetic studies. Methodology: A precise and accurate LC–MS/MS bioanalytical method has been developed and validated f
Autor:
Valerie Amann, Björn Peters, Albert D. M. E. Osterhaus, Patrick Obermeier, Xi Chen, Alla Heider, Susanne Duwe, Roland C. E. Francis, Brunhilde Schweiger, Marcel de Zwart, Oliver Miera, Felix Berger, Katharina Karsch, Barbara Rath, Pieter L. A. Fraaij
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 42:155-164
Patients with severe influenza virus infection, multi-organ failure and organ replacement therapy may absorb and metabolize neuraminidase inhibitors differently. Systematic pharmacokinetic/pharmacodynamic clinical trials are currently lacking in this
Autor:
Philip Timmerman, Marianne Scheel-Fjording, Bruno Le Bras, Alberto Guenzi, Stephen White, Daniel Neddermann, Berthold Lausecker, Susanne Globig, Marcel de Zwart
Publikováno v:
Bioanalysis. 8(19)
Interference testing of co-medication in bioanalytical method validation has become an area of debate in view of the increased specificity offered by current state-of-the-art technology in both LC–MS/MS and ligand-binding assay platforms. In view o
Autor:
Hans Mulder, Margarete Dr. Brudny-Klöppel, Marcel de Zwart, Ronald de Vries, Philip Timmerman, Achim Freisleben
Publikováno v:
Bioanalysis. 3:1333-1336
Since 2008, blood stability testing has gained considerable attention in the European Bioanalysis Forum (EBF) with discussions aiming to align processes, timing and reporting of analyte stability testing in blood as part of method development and val
Autor:
Carl Johan Sennbro, Sirpa Laakso, Dietmar Schmidt, Josep Maria Jansat, Achim Freisleben, Hans Mulder, Marcel de Zwart, Pierre Boulanger, Michael P. Andersen, Elizabeth Thomas, Stephanie Fischmann, Nathalie Mokrzycki-Issartel, Dirk Kasel, Morten A. Kall, Philip Timmerman, Richard Hucker, Fernando Romero, Stephen White, Berthold Lausecker, Susanne Globig, Silke Luedtke, Ben Gordon, Norbert Knebel, Peter van Amsterdam, Magnus Knutsson, Richard Abbott, Margarete Brudny-Kloeppel
Publikováno v:
Bioanalysis. 1:1049-1056
Following intensive discussions, review, alignment of procedures and multiple surveys among their member companies, the European Bioanalysis Forum (EBF) is providing a recommendation on how to integrate incurred sample reproducibility (ISR) in the bi
Autor:
Sjoerd van Marle, Pierre Peeters, Alex Zwiers, Marcel de Zwart, Marlou van Iersel, Saskia van de Wetering-Krebbers, Jean Smeets, Paul C. C. M. Passier, Diels van den Dobbelsteen
Publikováno v:
Biopharmaceuticsdrug disposition. 32(3)
Sugammadex is a modified γ-cyclodextrin which rapidly reverses rocuronium-and vecuronium-induced neuromuscular blockade. Previous studies suggest that sugammadex is mostly excreted unchanged via the kidneys. This single-center, open-label, non-rando
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 914:162-169
The influence of the steric hindrance of halogen substituents was investigated in vitro by measuring the activity of yeast aldehyde dehydrogenase (aldehyde:NAD(P) + oxidoreductase, EC 1.2.1.5) and of aldehyde dehydrogenases in subcellular rat liver f