Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Marcel Smid"'
Autor:
Hayri E. Balcioglu, Rebecca Wijers, Marcel Smid, Dora Hammerl, Anita M. Trapman-Jansen, Astrid Oostvogels, Mieke Timmermans, John W. M. Martens, Reno Debets
Publikováno v:
npj Imaging, Vol 2, Iss 1, Pp 1-16 (2024)
Abstract Spatial distribution of intra-tumoral immune cell populations is considered a critical determinant of tumor evolution and response to therapy. The accurate and systemic search for contexture-based predictors would be accelerated by methods t
Externí odkaz:
https://doaj.org/article/733e98348fbc41bb8568effad054c1dc
Autor:
Noortje Verschoor, Marcel Smid, Agnes Jager, Stefan Sleijfer, Saskia M. Wilting, John W. M. Martens
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact characteristics which prohibit clinical response to anti-HER2 therapies and drive disease progression are not
Externí odkaz:
https://doaj.org/article/eb68c979d7994380af5986176e6bfa77
Autor:
Noortje Verschoor, Vanja de Weerd, Mai N. Van, Jaco Kraan, Marcel Smid, Joan B. Heijns, Jan C. Drooger, Johanna M. Zuetenhorst, Annemieke van der Padt-Pruijsten, Agnes Jager, Stefan Sleijfer, John W. M. Martens, Saskia M. Wilting
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract This prospective cohort study reports aneuploidy score by mFast-SeqS as a strong prognostic marker in MBC patients. mFAST-SeqS is an affordable and easily implementable method for the assessment of total ctDNA levels and, as such, provides a
Externí odkaz:
https://doaj.org/article/a91a32dd499f413bab3e0ca153172941
Autor:
Marcel Smid, Marjanka K. Schmidt, Wendy J. C. Prager-van der Smissen, Kirsten Ruigrok-Ritstier, Maartje A. C. Schreurs, Sten Cornelissen, Aida Marsal Garcia, Annegien Broeks, A. Mieke Timmermans, Anita M. A. C. Trapman-Jansen, J. Margriet Collée, Muriel A. Adank, Maartje J. Hooning, John W. M. Martens, Antoinette Hollestelle
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background CHEK2 c.1100delC was the first moderate-risk breast cancer (BC) susceptibility allele discovered. Despite several genomic, transcriptomic and functional studies, however, it is still unclear how exactly CHEK2 c.1100delC promotes t
Externí odkaz:
https://doaj.org/article/8c35660b50404179bb0c665e16566e2a
Autor:
Zi Wang, Bircan Coban, Haoyu Wu, Jihed Chouaref, Lucia Daxinger, Michelle T. Paulsen, Mats Ljungman, Marcel Smid, John W. M. Martens, Erik H. J. Danen
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Grainyhead like 2 (GRHL2) is an essential transcription factor for development and function of epithelial tissues. It has dual roles in cancer by supporting tumor growth while suppressing epithelial to mesenchymal transitions (EMT). GRHL2 co
Externí odkaz:
https://doaj.org/article/66354d7f23a046039396b5df2989ebe4
Autor:
Nadine S. van den Ende, Marcel Smid, Annemieke Timmermans, Johannes B. van Brakel, Tim Hansum, Renée Foekens, Anita M. A. C. Trapman, Bernadette A. M. Heemskerk-Gerritsen, Agnes Jager, John W. M. Martens, Carolien H. M. van Deurzen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Currently, the human epidermal growth factor receptor 2 (HER2) status of breast cancer is classified dichotomously as negative or positive to select patients for HER2-targeted therapy. However, with the introduction of novel treatment option
Externí odkaz:
https://doaj.org/article/1448d637237d462d8270542e5a582e3c
Autor:
Lindsay Angus, Marcel Smid, Saskia M. Wilting, Manouk K. Bos, Neeltje Steeghs, Inge R. H. M. Konings, Vivianne C. G. Tjan-Heijnen, Johanna M. G. H. van Riel, Agnes J. van de Wouw, CPCT Consortium, Edwin Cuppen, Martijn P. Lolkema, Agnes Jager, Stefan Sleijfer, John W. M. Martens
Publikováno v:
Cancers, Vol 15, Iss 17, p 4416 (2023)
Mutations in the estrogen receptor gene (ESR1), its transcriptional regulators, and the mitogen-activated protein kinase (MAPK) pathway are enriched in patients with endocrine-resistant metastatic breast cancer (MBC). Here, we integrated whole genome
Externí odkaz:
https://doaj.org/article/20cce45044e24c7984aa2046e7d671d0
Autor:
Inge van denBerg, Marcel Smid, Robert R. J. Coebergh van den Braak, Mark A. van deWiel, Carolien H. M. vanDeurzen, Vanja deWeerd, John W. M. Martens, Jan N. M. IJzermans, Saskia M. Wilting
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3348-3362 (2021)
Consensus molecular subtypes (CMSs) can guide precision treatment of colorectal cancer (CRC). We aim to identify methylation markers to distinguish between CMS2 and CMS3 in patients with CRC, for which an easy test is currently lacking. To this aim,
Externí odkaz:
https://doaj.org/article/00cc8da0246e4a18907d6f294fb0eba1
Autor:
Dora Hammerl, John W. M. Martens, Mieke Timmermans, Marcel Smid, Anita M. Trapman-Jansen, Renée Foekens, Olga I. Isaeva, Leonie Voorwerk, Hayri E. Balcioglu, Rebecca Wijers, Iris Nederlof, Roberto Salgado, Hugo Horlings, Marleen Kok, Reno Debets
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Only a subset of triple negative breast cancer patients respond to immunotherapy. Here, the authors analysed spatial immune contextures, which can be captured by a gene classifier, in relation to genomic alterations, mechanisms of T cell evasion and
Externí odkaz:
https://doaj.org/article/c987387dc5c94a1b93ac3cb4c523d2fd
Autor:
Esmee Koedoot, Liesanne Wolters, Marcel Smid, Peter Stoilov, Gerhard A. Burger, Bram Herpers, Kuan Yan, Leo S. Price, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 BC c
Externí odkaz:
https://doaj.org/article/57418be9999441f5885dc1b1785fe4d6