Výsledky vyhledávání - "Marcel Schiff"

Akademický článek

Neutrophil extracellular trap formation during surgical procedures: a pilot study

Autor: Melody Ying-Yu Huang, Christoph Lippuner, Marcel Schiff, Malte Book, Frank Stueber

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Neutrophils can release neutrophil extracellular traps (NETs) containing DNA fibres and antimicrobial peptides to immobilize invading pathogens. NET formation (NETosis) plays a vital role in inflammation and immune responses. In this study w

Externí odkaz: https://doaj.org/article/d38c996ecb72494499741c72fbfa581b

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Akademický článek

Technical Approach Determines Inflammatory Response after Surgical and Transcatheter Aortic Valve Replacement.

Autor: Gabor Erdoes, Christoph Lippuner, Istvan Kocsis, Marcel Schiff, Monika Stucki, Thierry Carrel, Stephan Windecker, Balthasar Eberle, Frank Stueber, Malte Book

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143089 (2015)

To investigate the periprocedural inflammatory response in patients with isolated aortic valve stenosis undergoing surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) with different technical approaches.Patients

Externí odkaz: https://doaj.org/article/04456aee6acf45cc9e380f1685f877cf

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Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling

Publikováno v: Science translational medicine. 14(676)

Acute graft-versus-host disease (aGVHD), which is driven by allogeneic T cells, has a high mortality rate and limited treatment options. Human β-defensin 2 (hBD-2) is an endogenous epithelial cell–derived host-defense peptide. In addition to its a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02539a3d96ab39fd9e3a24c9a97b3b33
https://pubmed.ncbi.nlm.nih.gov/36542690

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Development and Evaluation of a Droplet Digital PCR Assay for 8p23 β-Defensin Cluster Copy Number Determination

Autor: Frank Stüber, Xianghong Zhang, Christoph Lippuner, Tingting Wen, Marcel Schiff

Publikováno v: Molecular Diagnosis & Therapy

Introduction It has been proposed that the copy number (CN) variation (CNV) in β-defensin genes (DEFB) on human chromosome 8p23 determines phenotypic differences in inflammatory diseases. However, no method for accurate and easy DEFB CN quantificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4664130f0843858b6fb9e4c29e3c4187
https://doi.org/10.1007/s40291-021-00546-2

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ERK and p38 contribute to the regulation of nociceptin and the nociceptin receptor in human peripheral blood leukocytes

Autor: Christoph Lippuner, Lan Zhang, Frank Stüber, Marcel Schiff, Ulrike M. Stamer

Publikováno v: Molecular Pain
Zhang, Lan; Stüber, Frank; Lippuner, Christoph; Schiff, Marcel; Stamer, Ulrike M (2019). ERK and p38 contribute to the regulation of nociceptin and the nociceptin receptor in human peripheral blood leukocytes. Molecular pain, 15, p. 1744806919828921. Sage 10.1177/1744806919828921

Little is known about the mechanisms involved in the regulation of nociceptin and its receptor (nociceptin opioid peptide receptor, NOP) in response to inflammation and pain in humans. In this study, specific signaling pathways contributing to the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e2ce827cf1ac89cb95b1265c280846
https://pubmed.ncbi.nlm.nih.gov/30665329

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Phorbol-12-myristate-13-acetate induces nociceptin in human Mono Mac 6 cells via multiple transduction signalling pathways

Autor: Frank Stüber, Christoph Lippuner, Marcel Schiff, Ulrike M. Stamer, Lan Zhang

Publikováno v: British Journal of Anaesthesia. 117:250-257

BACKGROUND Nociceptin in the peripheral circulation has been proposed to have an immunoregulatory role with regards to inflammation and pain. However, the mechanisms involved in its regulation are still not clear. The aim of this study was to investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb0d60959ed0f18216045066a81da7a
https://doi.org/10.1093/bja/aew063

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