Výsledky vyhledávání - "Marcel Proske"

Akademický článek

PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

Autor: Marcel Proske, Robert Janowski, Sabrina Bacher, Hyun-Seo Kang, Thomas Monecke, Tony Koehler, Saskia Hutten, Jana Tretter, Anna Crois, Lena Molitor, Alejandro Varela-Rial, Roberto Fino, Elisa Donati, Gianni De Fabritiis, Dorothee Dormann, Michael Sattler, Dierk Niessing

Publikováno v: eLife, Vol 13 (2024)

Mutations in the human PURA gene cause the neurodevelopmental PURA syndrome. In contrast to several other monogenetic disorders, almost all reported mutations in this nucleic acid-binding protein result in the full disease penetrance. In this study,

Externí odkaz: https://doaj.org/article/13d881e49c7c4676869b2c6bc60d831e

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Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies

Publikováno v: Nucleic Acids Research, 51(3), 1297–1316

The RNA-binding protein PURA has been implicated in the rare, monogenetic, neurodevelopmental disorder PURA Syndrome. PURA binds both DNA and RNA and has been associated with various cellular functions. Only little is known about its main cellular ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e54f5c511014206578ff43d59b0ea5
https://doi.org/10.1101/2022.02.09.479353

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Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis

Autor: Roland Kontermann, John R. Bethea, Maëlle Duffey, Marcel Proske, Nathalie Peters, George F. Martinez, Rainer H. Straub, Hubert Stangl, Alexandra Kraske, Roman Fischer, Klaus Pfizenmaier

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 70(5)

Objective. Treg cells modulate immune responses and can suppress the development of autoimmune diseases. Tumor necrosis factor receptor II (TNFRII) has been recognized as a key receptor on these cells that facilitates expansion and stabilization of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395460f1cfe4e27b0d5bfa00908de057
https://pubmed.ncbi.nlm.nih.gov/29342501

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