Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Marcel O. Schmidt"'
Autor:
Megan E. McNamara, Netanel Loyfer, Amber J. Kiliti, Marcel O. Schmidt, Sapir Shabi-Porat, Sidharth S. Jain, Sarah Martinez Roth, A. Patrick McDeed IV, Nesreen Shahrour, Elizabeth Ballew, Yun-Tien Lin, Heng-Hong Li, Anne Deslattes Mays, Sonali Rudra, Anna T. Riegel, Keith Unger, Tommy Kaplan, Anton Wellstein
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Radiation therapy is an effective cancer treatment, although damage to healthy tissues is common. Here we analyzed cell-free, methylated DNA released from dying cells into the circulation to evaluate radiation-induced cellular damage in different tis
Externí odkaz:
https://doaj.org/article/0eb9bcb8aa8b40a4ba4c47c4e39aa949
Autor:
Yuan-Na Lin, Marcel O. Schmidt, Ghada M. Sharif, Eveline E. Vietsch, Amber J. Kiliti, Megan E. Barefoot, Anna T. Riegel, Anton Wellstein
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Pancreatic cancer remains largely unresponsive to immune modulatory therapy attributable in part to an immunosuppressive, desmoplastic tumor microenvironment. Here, we analyze mechanisms of cancer cell-autonomous resistance to T cells. We used a 3D c
Externí odkaz:
https://doaj.org/article/2d24f4c980be417c897fa5b984546e5d
Autor:
Sarah Martinez Roth, Eveline E. Vietsch, Megan E. Barefoot, Marcel O. Schmidt, Matthew D. Park, Archana Ramesh, Michael R. Lindberg, Giuseppe Giaccone, Anna T. Riegel, Ana Barac, Keith Unger, Anton Wellstein
Publikováno v:
Gastrointestinal Disorders, Vol 3, Iss 3, Pp 100-112 (2021)
Thoracic high-dose radiation therapy (RT) for cancer has been associated with early and late cardiac toxicity. To assess altered rates of cardiomyocyte cell death due to RT we monitored changes in cardiomyocyte-specific, cell-free methylated DNA (cfD
Externí odkaz:
https://doaj.org/article/44f090ede39b42859e5a5e78d9c4ff96
Autor:
Irfan Khan, Marcel O. Schmidt, Bhaskar Kallakury, Sidharth Jain, Shaunt Mehdikhani, Moshe Levi, Margarida Mendonca, William Welch, Anna T. Riegel, Christopher S. Wilcox, Anton Wellstein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Angiotensin II can cause oxidative stress and increased blood pressure that result in long term cardiovascular pathologies. Here we evaluated the contribution of cellular senescence to the effect of chronic exposure to low dose angiotensin II in a mo
Externí odkaz:
https://doaj.org/article/d41988e59090480dbfe41577baebf916
Autor:
Anna T. Riegel, Anton Wellstein, Susan Fineberg, Olivier Loudig, Gray W. Pearson, Marcel O. Schmidt, William B. Kietzman, Max H. Kushner, Garrett T. Graham, Surojeet Sengupta, Apsra Nasir, Moray J. Campbell, Ghada M. Sharif
A) Representative images of hematoxylin and eosin (H&E) staining of MCFDCIS, MCFDCIS-Î"4 and mixed (4:1 respectively) tumors that were injected in the mammary fat pad of SCID/Beige mice after two or five weeks. MCFDCIS-Î"4 tumors were not collected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352c9cf9fefdf170b043c933ba307a7f
https://doi.org/10.1158/0008-5472.22429281.v1
https://doi.org/10.1158/0008-5472.22429281.v1
Autor:
Anna T. Riegel, Anton Wellstein, Susan Fineberg, Olivier Loudig, Gray W. Pearson, Marcel O. Schmidt, William B. Kietzman, Max H. Kushner, Garrett T. Graham, Surojeet Sengupta, Apsra Nasir, Moray J. Campbell, Ghada M. Sharif
A list of differentially expressed genes in tumors and cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4379f46dccf681b1ffdedea34ec9d7cf
https://doi.org/10.1158/0008-5472.22429263
https://doi.org/10.1158/0008-5472.22429263
Autor:
Anna T. Riegel, Anton Wellstein, Susan Fineberg, Olivier Loudig, Gray W. Pearson, Marcel O. Schmidt, William B. Kietzman, Max H. Kushner, Garrett T. Graham, Surojeet Sengupta, Apsra Nasir, Moray J. Campbell, Ghada M. Sharif
AIB1Δ4 is an N-terminally truncated isoform of the oncogene amplified in breast cancer 1 (AIB1) with increased expression in high-grade human ductal carcinoma in situ (DCIS). However, the role of AIB1Δ4 in DCIS malignant progression has not been de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04cdfc313a1dd7450a17dd0818ceea5
https://doi.org/10.1158/0008-5472.c.6513300.v1
https://doi.org/10.1158/0008-5472.c.6513300.v1
Autor:
Anna T. Riegel, Anton Wellstein, Susan Fineberg, Olivier Loudig, Gray W. Pearson, Marcel O. Schmidt, William B. Kietzman, Max H. Kushner, Garrett T. Graham, Surojeet Sengupta, Apsra Nasir, Moray J. Campbell, Ghada M. Sharif
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293fd4f21614cac5a86ac9ddf2276ed3
https://doi.org/10.1158/0008-5472.22429269.v1
https://doi.org/10.1158/0008-5472.22429269.v1
Autor:
Debolina Ganguly, Marcel O. Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T.A. Dominguez, Gilbert Z. Murimwa, Jason E. Toombs, Cheryl Lewis, Yisheng V. Fang, Fatima Valdes-Mora, David Gallego-Ortega, Anton Wellstein, Rolf A. Brekken
Publikováno v:
Journal of Experimental Medicine. 220
Metastatic cancer cells adapt to thrive in secondary organs. To investigate metastatic adaptation, we performed transcriptomic analysis of metastatic and non-metastatic murine breast cancer cells. We found that pleiotrophin (PTN), a neurotrophic cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71ac9d8fd9e385820cf2f039b85e531
https://doi.org/10.1084/jem.20220610
https://doi.org/10.1084/jem.20220610
Autor:
Gregory T. Gallanis, Ghada M. Sharif, Marcel O. Schmidt, Benjamin N. Friedland, Rohith Battina, Raneen Rahhal, John E. Davis, Irfan S. Khan, Anton Wellstein, Anna T. Riegel
Publikováno v:
Cancers; Volume 15; Issue 6; Pages: 1908
Background: CDK4/6 inhibitors (CDKi) have improved disease control in hormone-receptor-positive, HER2-negative metastatic breast cancer, but most patients develop progressive disease. Methods: We asked whether host stromal senescence after CDK4/6 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c2c152b8fc8adec7a9693b7f48ec70
https://doi.org/10.3390/cancers15061908
https://doi.org/10.3390/cancers15061908