Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Marcel Mettlen"'
Autor:
Yafeng Li, Jessica S. Hook, Qing Ding, Xue Xiao, Stephen S. Chung, Marcel Mettlen, Lin Xu, Jessica G. Moreland, Michalis Agathocleous
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Severe COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. However, it is not known how the metabolome of immune cells changes in patients with COVID-19. To address
Externí odkaz:
https://doaj.org/article/d8af6e23b4bc43b68061b3cd5ae0f3dd
Autor:
M. Carmen Lafita-Navarro, Yi-Heng Hao, Chunhui Jiang, Seoyeon Jang, Tsung-Cheng Chang, Isabella N. Brown, Niranjan Venkateswaran, Elizabeth Maurais, Weronika Stachera, Yanfeng Zhang, Dorothy Mundy, Jungsoo Han, Vanna M. Tran, Marcel Mettlen, Lin Xu, Jeffrey B. Woodruff, Nick V. Grishin, Lisa Kinch, Joshua T. Mendell, Michael Buszczak, Maralice Conacci-Sorrell
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113280- (2023)
Summary: Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRN
Externí odkaz:
https://doaj.org/article/c9443ad8099941449a8b52f34efe5875
Autor:
Kamalika Mukherjee, Changkyu Gu, Agnieszka Collins, Marcel Mettlen, Beata Samelko, Mehmet M. Altintas, Yashwanth R. Sudhini, Xuexiang Wang, Richard Bouley, Dennis Brown, Bradley P. Pedro, Susan L. Bane, Vineet Gupta, Paul T. Brinkkoetter, Henning Hagmann, Jochen Reiser, Sanja Sever
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
A common cellular manifestation for diverse kidney diseases is dysregulated actin cytoskeleton in distinct cell types that include glomerular podocytes and tubular epithelial cells. Here, authors pharmacologically activate dynamin and this results in
Externí odkaz:
https://doaj.org/article/de985803365d4a178cb549392c2a5749
Publikováno v:
eLife, Vol 9 (2020)
Clathrin-mediated endocytosis (CME) in mammalian cells is driven by resilient machinery that includes >70 endocytic accessory proteins (EAP). Accordingly, perturbation of individual EAPs often results in minor effects on biochemical measurements of C
Externí odkaz:
https://doaj.org/article/ec29e9076e244b2d8c3542148d96f22f
Autor:
Sofya S Perelman, Michael E Abrams, Jennifer L Eitson, Didi Chen, Alyssa Jimenez, Marcel Mettlen, John W Schoggins, Neal M Alto
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006102 (2016)
The type I interferon (IFN) activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes (Lm) as a model b
Externí odkaz:
https://doaj.org/article/f3851d44fbcc40029b201bfa961e9914
Autor:
Amberlyn M Wands, Akiko Fujita, Janet E McCombs, Jakob Cervin, Benjamin Dedic, Andrea C Rodriguez, Nicole Nischan, Michelle R Bond, Marcel Mettlen, David C Trudgian, Andrew Lemoff, Marianne Quiding-Järbrink, Bengt Gustavsson, Catharina Steentoft, Henrik Clausen, Hamid Mirzaei, Susann Teneberg, Ulf Yrlid, Jennifer J Kohler
Publikováno v:
eLife, Vol 4 (2015)
Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates i
Externí odkaz:
https://doaj.org/article/3c68ba7482ae44199ba3d13b04350700
Autor:
Dinah Loerke, Marcel Mettlen, Defne Yarar, Khuloud Jaqaman, Henry Jaqaman, Gaudenz Danuser, Sandra L Schmid
Publikováno v:
PLoS Biology, Vol 7, Iss 3, p e57 (2009)
Total internal reflection fluorescence microscopy (TIR-FM) has become a powerful tool for studying clathrin-mediated endocytosis. However, due to difficulties in tracking and quantifying their heterogeneous dynamic behavior, detailed analyses have be
Externí odkaz:
https://doaj.org/article/dee82b88b47643418049e9a69a4fab8c
Autor:
Hao Zhu, David Hsiehchen, Rolf A. Brekken, Tao Wang, Tianshi Lu, Debolina Ganguly, Marcel Mettlen, Andrew S. Chung
Two animals randomly selected from each group were sacrificed and showed no difference in tumor burden or T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045a17d030ee4c8527bcf76a0d536d20
https://doi.org/10.1158/1940-6207.22534820.v1
https://doi.org/10.1158/1940-6207.22534820.v1
Autor:
Hao Zhu, David Hsiehchen, Rolf A. Brekken, Tao Wang, Tianshi Lu, Debolina Ganguly, Marcel Mettlen, Andrew S. Chung
Cirrhosis is a high-risk state for hepatocellular carcinoma (HCC) development and represents an opportunity to prevent cancer. In the precancerous state of cirrhosis, there is an accumulation of neoantigens that may be specifically targetable through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5438ecf00963f1f1d5db13b7451176
https://doi.org/10.1158/1940-6207.c.6547667.v1
https://doi.org/10.1158/1940-6207.c.6547667.v1
Autor:
Hao Zhu, David Hsiehchen, Rolf A. Brekken, Tao Wang, Tianshi Lu, Debolina Ganguly, Marcel Mettlen, Andrew S. Chung
Figure Legends for Supplementary Figures S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821d16485a533e88a211c6f88a6915d8
https://doi.org/10.1158/1940-6207.22534838.v1
https://doi.org/10.1158/1940-6207.22534838.v1