LOV takes a pick: thermodynamic and structural aspects of the flavin-LOV-interaction of the blue-light sensitive photoreceptor YtvA from Bacillus subtilis.

Autor: Matthias Dorn, Marcel Jurk, Anne Wartenberg, Aaron Hahn, Peter Schmieder

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81268 (2013)

LOV domains act as versatile photochromic switches servicing multiple effector domains in a variety of blue light sensing photoreceptors abundant in a multitude of organisms from all kingdoms of life. The perception of light is realized by a flavin c

Externí odkaz: https://doaj.org/article/f2748ae125e94f96bb227a954242c51d

Blue news update: BODIPY-GTP binds to the blue-light receptor YtvA while GTP does not.

Autor: Matthias Dorn, Marcel Jurk, Peter Schmieder

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29201 (2012)

Light is an important environmental factor for almost all organisms. It is mainly used as an energy source but it is also a key factor for the regulation of multiple cellular functions. Light as the extracellular stimulus is thereby converted into an

Externí odkaz: https://doaj.org/article/5c18c929139b421c952a4f9294983251

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

Autor: Morgane Thomas-Chollier, Robert Schöpflin, Kevin Schwahn, Samantha B. Cooper, Martin Vingron, Keith R. Yamamoto, Michael I. Love, Sebastiaan H. Meijsing, Marcel Jurk, Matthew R. Huska, Stephan R. Starick

Publikováno v: Nucleic Acids Research (London)
Nucleic acids research, vol 45, iss 4
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (4), pp.1805-1819. ⟨10.1093/nar/gkw1163⟩
Nucleic Acids Research, 2017, 45 (4), pp.1805-1819. ⟨10.1093/nar/gkw1163⟩

International audience; The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where GR binds, we used Ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a88c77dc4f15807537d9a2bc9ed7212
https://doi.org/10.1093/nar/gkw1163

ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors

Autor: Marcel Jurk, Sebastiaan H. Meijsing, Martin Vingron, Morgane Thomas-Chollier, Michael I. Love, Jonas Ibn-Salem, Ho-Ryun Chung, Stephan R. Starick, Céline Hernandez

Publikováno v: Genome Research
Genome Research, Cold Spring Harbor Laboratory Press, 2015, 25 (6), pp.825-835. ⟨10.1101/gr.185157.114⟩
Genome Research, 2015, 25 (6), pp.825-835. ⟨10.1101/gr.185157.114⟩
Genome Res

The classical DNA recognition sequence of the glucocorticoid receptor (GR) appears to be present at only a fraction of bound genomic regions. To identify sequences responsible for recruitment of this transcription factor (TF) to individual loci, we t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694f8c781f0deae07332f08eba894e24
https://doi.org/10.1101/gr.185157.114

Correction: Corrigendum: Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

Autor: Martin Vingron, Marcel Jurk, Stefanie Schöne, Morgane Thomas-Chollier, Isabelle Lebars, Bruno Kieffer, Petra Imhof, Sebastiaan H. Meijsing, Iris Dror, Remo Rohs, Mahdi Bagherpoor Helabad

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications

The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site, differ depending on the strength

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d77edbad3ebf59317f1b1f99fdc8543
https://doi.org/10.1038/ncomms13784