Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Marcel Jiménez"'
Publikováno v:
Mathematics, Vol 10, Iss 15, p 2786 (2022)
This study reports a method for the detection of mechanical signaling anomalies in cardiac tissue through the use of deep learning and the design of two anomaly detectors. In contrast to anomaly classifiers, anomaly detectors allow accurate identific
Externí odkaz:
https://doaj.org/article/7fb36a1c1b3447b9b614d77c43506208
Autor:
Sergi Casabella-Ramón, Verónica Jiménez-Sábado, Carmen Tarifa, Sandra Casellas, Tien Tina Lu, Paloma Izquierdo-Castro, Ignasi Gich, Marcel Jiménez, Antonino Ginel, José M. Guerra, S. R. Wayne Chen, Raul Benítez, Leif Hove-Madsen
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1759 (2022)
A hallmark of atrial fibrillation is an excess of spontaneous calcium release events, which can be mimicked by β1- or β2-adrenergic stimulation. Because β1-adrenergic receptor blockers (β1-blockers) are primarily used in clinical practice, we her
Externí odkaz:
https://doaj.org/article/b16df02d7d89424ab62738492139134a
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Purpose. TRPV1 is a multimodal channel mainly expressed in sensory neurons. We aimed to explore the pharmacodynamics of the TRPV1 agonists, capsaicin, natural capsaicinoids, and piperine in an in vitro bioassay using human PC-3 cells and to examine d
Externí odkaz:
https://doaj.org/article/9de868c73ab647d787b2bc2c991b1ca3
Akademický článek
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Publikováno v:
Revista Espanola de Enfermedades Digestivas, Vol 108, Iss 11, Pp 721-731
The enteric nervous system (ENS) is responsible for the genesis of motor patterns ensuring an appropriate intestinal transit. Enteric motor neurons are classified into afferent neurons, interneurons and motorneurons. Motorneurons are excitatory or in
Externí odkaz:
https://doaj.org/article/49b89a75a460467196164e2727d5bf81
Autor:
Laura Díaz-Marugan, Mattia Gallizioli, Leonardo Márquez-Kisinousky, Silvia Arboleya, Annalaura Mastrangelo, Francisca Ruiz-Jaén, Jordi Pedragosa, Climent Casals, Francisco Javier Morales, Sara Ramos-Romero, Sara Traserra, Carles Justicia, Miguel Gueimonde, Marcel Jiménez, Josep Lluís Torres, Xabier Urra, Ángel Chamorro, David Sancho, Clara G. de los Reyes-Gavilán, Francesc Miró-Mur, Anna M. Planas
Publikováno v:
Stroke.
Background: Respiratory and urinary tract infections are frequent complications in patients with severe stroke. Stroke-associated infection is mainly due to opportunistic commensal bacteria of the microbiota that may translocate from the gut. We inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a48e2ddea7165b3a396ad5b0a663f2e1
https://doi.org/10.1161/strokeaha.123.042755
https://doi.org/10.1161/strokeaha.123.042755
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility SocietyREFERENCES.
Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of HBB in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40be2c3fd3f6c74d317e4b51b543626f
https://pubmed.ncbi.nlm.nih.gov/35972266
https://pubmed.ncbi.nlm.nih.gov/35972266
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology.
Objectives Reactive oxygen and nitrogen species may be produced during inflammation leading to the formation of NO, H2S or HNO. Enzymes such as iNOS, CSE and CBS might also be responsible for polysulfide production. Since these signalling molecules m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b399c8950899eb9c480a1112e1f029
https://doi.org/10.1515/jbcpp-2021-0181
https://doi.org/10.1515/jbcpp-2021-0181
Autor:
Anna Accarino, Lucia Relea, Sara Traserra, Marcel Jiménez, Claudia Barber, Patri Vergara, Lewis C. MacPherson, Charles Kennedy, Margaret R. Cunningham, Jane Maclnnes
Background: Gastrointestinal smooth muscle relaxation is accomplished by activation of P2Y 1 receptors, therefore this receptor plays an important role in regulation of gut motility. Recently, BPTU was developed as a negative allosteric modulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0082f5ce18677b7e51be57d903a6f9bf
https://strathprints.strath.ac.uk/76419/1/Traserra_etal_2021_NM_Different_responses_of_the_blockade_of_the_P2Y1_receptor_with_BPTU_in_human_and_porcine_intestinal_tissues_and_in_cell_cultures.pdf
https://strathprints.strath.ac.uk/76419/1/Traserra_etal_2021_NM_Different_responses_of_the_blockade_of_the_P2Y1_receptor_with_BPTU_in_human_and_porcine_intestinal_tissues_and_in_cell_cultures.pdf
Publikováno v:
European Journal of Pharmacology. 855:160-166
P2Y1 receptors play an essential role in inhibitory neuromuscular transmission in the gastrointestinal tract. The signalling pathway involves the opening of small conductance calcium activated potassium-channels (Kca2 family) that results in smooth m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841a121a5fe5d20d1c016b910c04054f
https://doi.org/10.1016/j.ejphar.2019.05.013
https://doi.org/10.1016/j.ejphar.2019.05.013